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Conserved domains on  [gi|1653961015|ref|NP_689551|]
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zymogen granule membrane protein 16 precursor [Homo sapiens]

Protein Classification

jacalin family lectin; zinc metalloproteinase family protein( domain architecture ID 10176317)

jacalin family lectin is a sugar-binding protein containing a jacalin domain| zinc metalloproteinase family protein contains an HEXXH motif characteristic of metallopeptidases; contains a Jacalin-like lectin domain that may bind mono- or oligosaccharides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 36-158 8.02e-52

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


:

Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 161.34  E-value: 8.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  36 KRFSHSGNqLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKG 115
Cdd:cd09611     6 KYFSDVGE-GGGPITGIRVSVGNNYIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVFTTNKG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1653961015 116 RYLSFGKDSGTSFNAVPLHPNTVLRFISGRS-GSLIDAIGLHWD 158
Cdd:cd09611    85 RYLSFGKLRGRSFNATPPPSNYVLRGISGRYgGLGIKSIGFHWG 128
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 36-158 8.02e-52

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 161.34  E-value: 8.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  36 KRFSHSGNqLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKG 115
Cdd:cd09611     6 KYFSDVGE-GGGPITGIRVSVGNNYIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVFTTNKG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1653961015 116 RYLSFGKDSGTSFNAVPLHPNTVLRFISGRS-GSLIDAIGLHWD 158
Cdd:cd09611    85 RYLSFGKLRGRSFNATPPPSNYVLRGISGRYgGLGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 49-158 3.75e-26

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 96.14  E-value: 3.75e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015   49 ITALRVRVNTYYIVGLQVRYGK---VWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKW--YLKKLVFVTDKGRYLSFGKD 123
Cdd:smart00915  12 VRKIYVGQGGEGIKSIQFDYDKggkVWGDEHGGKGGTGEEILLYPGEYITSVEGTYDKsgVITSLTFKTNKGRTSPFGGY 91

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1653961015  124 SGTSFNAVPLHPNTVLRFISGR-SGSLIDAIGLHWD 158
Cdd:smart00915  92 EGGTKFVLESKEGKKIVGFHGRsSGDGLDSLGAYFS 127
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 69-157 1.39e-06

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 45.35  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  69 GKVWSDYVGGRNGDLEEIFL--HPGESVIQVSGKYKWY-------LKKLVFVTDKGRYLS-FGKDSGTSFNaVPLHPNTV 138
Cdd:pfam01419  36 GKVEGDEHGKKGLLGPEEFEidYPDEYITSVEGTYDKVfgsdsevITSLTFKTNKGRTSPfFGTPSGTKFS-LEVKGKKI 114

                          90
                  ....*....|....*....
gi 1653961015 139 LRFiSGRSGSLIDAIGLHW 157
Cdd:pfam01419 115 VGF-HGRAGNALNALGAYF 132
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 36-158 8.02e-52

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 161.34  E-value: 8.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  36 KRFSHSGNqLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKG 115
Cdd:cd09611     6 KYFSDVGE-GGGPITGIRVSVGNNYIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVFTTNKG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1653961015 116 RYLSFGKDSGTSFNAVPLHPNTVLRFISGRS-GSLIDAIGLHWD 158
Cdd:cd09611    85 RYLSFGKLRGRSFNATPPPSNYVLRGISGRYgGLGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 49-158 3.75e-26

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 96.14  E-value: 3.75e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015   49 ITALRVRVNTYYIVGLQVRYGK---VWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKW--YLKKLVFVTDKGRYLSFGKD 123
Cdd:smart00915  12 VRKIYVGQGGEGIKSIQFDYDKggkVWGDEHGGKGGTGEEILLYPGEYITSVEGTYDKsgVITSLTFKTNKGRTSPFGGY 91

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1653961015  124 SGTSFNAVPLHPNTVLRFISGR-SGSLIDAIGLHWD 158
Cdd:smart00915  92 EGGTKFVLESKEGKKIVGFHGRsSGDGLDSLGAYFS 127
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 49-156 1.34e-12

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 61.04  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  49 ITALRVRVNTYYIVGLQVRY----GKVWSDYVGGRNGDLEEIFL-HPGESVIQVSG---KYKWY--LKKLVFVTDKGRYL 118
Cdd:cd09612    13 LRKITVRSGENGIDSIKFEYdkdgQHVVGPWHGGGGGTPEEIVLdYPDEYITSVSGtygPVSGSnvITSLTFKTNKRTYG 92

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1653961015 119 SFGKDSGTSFNaVPLHPNTVLRFiSGRSGSLIDAIGLH 156
Cdd:cd09612    93 PFGVESGTPFS-LPVEGGKIVGF-HGRSGDYLDAIGVY 128
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 49-157 5.45e-09

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 51.63  E-value: 5.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  49 ITALRVRVNtYYIVGLQVRYGKVWSDYVGGRNGD-LEEIFLHPGESVIQVSGK-----YKWYLKKLVFVTDKGRYLSFGK 122
Cdd:cd09302    14 LTEIRVRSG-GAVDAIRVVLRDYTDGRHGGNGGPnTSSVFLDPGEYITITSVSsgdngGGTRIDAIQFTTNKGRSGTYGT 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1653961015 123 DSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHW 157
Cdd:cd09302    93 TSGALGTEFTVPVGGEIVGIYGRAGDDVDAFGFIL 127
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 69-157 1.39e-06

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 45.35  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  69 GKVWSDYVGGRNGDLEEIFL--HPGESVIQVSGKYKWY-------LKKLVFVTDKGRYLS-FGKDSGTSFNaVPLHPNTV 138
Cdd:pfam01419  36 GKVEGDEHGKKGLLGPEEFEidYPDEYITSVEGTYDKVfgsdsevITSLTFKTNKGRTSPfFGTPSGTKFS-LEVKGKKI 114

                          90
                  ....*....|....*....
gi 1653961015 139 LRFiSGRSGSLIDAIGLHW 157
Cdd:pfam01419 115 VGF-HGRAGNALNALGAYF 132
griffithsin_like cd09614
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
 40-156 1.49e-04

Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.


Pssm-ID: 187710  Cd Length: 128  Bit Score: 39.69  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961015  40 HSGNQLDGPITALRvrvntYYIVGLQVRYGkvwsdyvGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVT-DKGRYL 118
Cdd:cd09614    21 RSGSYVDQIITDYQ-----DLNGTQNFHHG-------GGGGNLSPTLNFSSGEYITEVTGRSGDRVDQVQFTTnYGGRTL 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1653961015 119 SFGKDSGTSFNAVPlHPNTVLRFISGRSGSLIDAIGLH 156
Cdd:cd09614    89 PGGGGGGSAFTWTV-PDNQKVIGFAGRSGSYLDQLQVY 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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