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    CDK19 cyclin dependent kinase 19 [ Homo sapiens (human) ]

    Gene ID: 23097, updated on 10-Dec-2024

    Summary

    Official Symbol
    CDK19provided by HGNC
    Official Full Name
    cyclin dependent kinase 19provided by HGNC
    Primary source
    HGNC:HGNC:19338
    See related
    Ensembl:ENSG00000155111 MIM:614720; AllianceGenome:HGNC:19338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3
    Summary
    This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDK19 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (110609978..110815855, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111788546..111994459, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110931181..111137058, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24935 Neighboring gene abhydrolase domain containing 10, depalmitoylase pseudogene Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110967777-110968713 Neighboring gene ribosomal protein S20 pseudogene 18 Neighboring gene uncharacterized LOC124901502 Neighboring gene RNA, U6 small nuclear 957, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24937 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111135767-111136319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24938 Neighboring gene MPRA-validated peak6028 silencer Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene RNA, U6 small nuclear 1115, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 40C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1028

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    part_of CKM complex  
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    cyclin-dependent kinase 19
    Names
    CDC2-related protein kinase 6
    CDK8-like cyclin-dependent kinase
    cell division cycle 2-like 6 (CDK8-like)
    cell division cycle 2-like protein kinase 6
    cell division protein kinase 19
    cyclin-dependent kinase (CDC2-like) 11
    cyclin-dependent kinase 11
    death-preventing kinase
    NP_001287889.1
    NP_001287892.1
    NP_001287893.1
    NP_055891.1
    XP_005266928.1
    XP_011533932.2
    XP_024302144.2
    XP_024302145.1
    XP_024302146.1
    XP_024302148.1
    XP_047274421.1
    XP_047274423.1
    XP_047274424.1
    XP_047274425.1
    XP_047274426.1
    XP_047274427.1
    XP_047274428.1
    XP_047274429.1
    XP_054210782.1
    XP_054210783.1
    XP_054210784.1
    XP_054210785.1
    XP_054210786.1
    XP_054210787.1
    XP_054210788.1
    XP_054210789.1
    XP_054210790.1
    XP_054210791.1
    XP_054210792.1
    XP_054210793.1
    XP_054210794.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300960.2 → NP_001287889.1  cyclin-dependent kinase 19 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AB028951, AY028424, JX028238, Z84480
      UniProtKB/TrEMBL
      I6W807
      Conserved Domains (2) summary
      smart00220
      Location:22 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:18 → 291
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001300963.2 → NP_001287892.1  cyclin-dependent kinase 19 isoform 3

      See identical proteins and their annotated locations for NP_001287892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AB028951, BC024247, Z84480
      Consensus CDS
      CCDS75503.1
      UniProtKB/TrEMBL
      A8K8J5
      Related
      ENSP00000317665.3, ENST00000323817.7
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001300964.2 → NP_001287893.1  cyclin-dependent kinase 19 isoform 3

      See identical proteins and their annotated locations for NP_001287893.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AB028951, DB030002
      Consensus CDS
      CCDS75503.1
      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain
    4. NM_015076.5 → NP_055891.1  cyclin-dependent kinase 19 isoform 1

      See identical proteins and their annotated locations for NP_055891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB028951, AY028424, Z84480
      Consensus CDS
      CCDS5085.1
      UniProtKB/Swiss-Prot
      Q5JQZ7, Q5JR00, Q8TC78, Q9BWU1, Q9UPX2
      UniProtKB/TrEMBL
      A8K8J5
      Related
      ENSP00000357907.3, ENST00000368911.8
      Conserved Domains (1) summary
      cd07867
      Location:18 → 335
      STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      110609978..110815855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418470.1 → XP_047274426.1  cyclin-dependent kinase 19 isoform X6

      UniProtKB/TrEMBL
      Q9UFE3
    2. XM_011535630.3 → XP_011533932.2  cyclin-dependent kinase 19 isoform X4

      UniProtKB/TrEMBL
      F6QTA4, I6W807
      Related
      ENSP00000410604.3, ENST00000413605.6
    3. XM_024446376.2 → XP_024302144.2  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    4. XM_047418467.1 → XP_047274423.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    5. XM_047418469.1 → XP_047274425.1  cyclin-dependent kinase 19 isoform X3

      UniProtKB/TrEMBL
      A8K8J5
    6. XM_024446377.2 → XP_024302145.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain
    7. XM_024446380.2 → XP_024302148.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain
    8. XM_024446378.2 → XP_024302146.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain
    9. XM_047418468.1 → XP_047274424.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    10. XM_047418465.1 → XP_047274421.1  cyclin-dependent kinase 19 isoform X1

      UniProtKB/TrEMBL
      A8K8J5
    11. XM_047418471.1 → XP_047274427.1  cyclin-dependent kinase 19 isoform X7

      UniProtKB/TrEMBL
      Q9UFE3
    12. XM_005266871.4 → XP_005266928.1  cyclin-dependent kinase 19 isoform X5

      See identical proteins and their annotated locations for XP_005266928.1

      UniProtKB/TrEMBL
      B4DUB1, Q9UFE3
      Conserved Domains (1) summary
      cl21453
      Location:28 → 211
      PKc_like; Protein Kinases, catalytic domain
    13. XM_047418472.1 → XP_047274428.1  cyclin-dependent kinase 19 isoform X7

      UniProtKB/TrEMBL
      Q9UFE3
    14. XM_047418473.1 → XP_047274429.1  cyclin-dependent kinase 19 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      111788546..111994459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354815.1 → XP_054210790.1  cyclin-dependent kinase 19 isoform X6

      UniProtKB/TrEMBL
      Q9UFE3
    2. XM_054354813.1 → XP_054210788.1  cyclin-dependent kinase 19 isoform X4

      UniProtKB/TrEMBL
      F6QTA4, I6W807
    3. XM_054354807.1 → XP_054210782.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    4. XM_054354812.1 → XP_054210787.1  cyclin-dependent kinase 19 isoform X3

      UniProtKB/TrEMBL
      A8K8J5
    5. XM_054354819.1 → XP_054210794.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    6. XM_054354810.1 → XP_054210785.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    7. XM_054354809.1 → XP_054210784.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    8. XM_054354808.1 → XP_054210783.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    9. XM_054354811.1 → XP_054210786.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
    10. XM_054354816.1 → XP_054210791.1  cyclin-dependent kinase 19 isoform X7

      UniProtKB/TrEMBL
      Q9UFE3
    11. XM_054354814.1 → XP_054210789.1  cyclin-dependent kinase 19 isoform X5

      UniProtKB/TrEMBL
      B4DUB1, Q9UFE3
    12. XM_054354817.1 → XP_054210792.1  cyclin-dependent kinase 19 isoform X7

      UniProtKB/TrEMBL
      Q9UFE3
    13. XM_054354818.1 → XP_054210793.1  cyclin-dependent kinase 19 isoform X8

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