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    POU2F2 POU class 2 homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 5452, updated on 10-Dec-2024

    Summary

    Official Symbol
    POU2F2provided by HGNC
    Official Full Name
    POU class 2 homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:9213
    See related
    Ensembl:ENSG00000028277 MIM:164176; AllianceGenome:HGNC:9213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCT2; OTF2; Oct-2
    Summary
    The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in lymph node (RPKM 11.8), spleen (RPKM 7.4) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See POU2F2 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42086110..42197936, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44905480..45017310, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42590262..42681458, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10682 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42536134-42536906 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42539441-42539940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10684 Neighboring gene zinc finger protein 574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14702 Neighboring gene Sharpr-MPRA regulatory region 1615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42653684-42654184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42654185-42654685 Neighboring gene microRNA 4323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42659146-42659674 Neighboring gene long non-coding regulator of POU2F2 Neighboring gene POU2F2 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42669363-42669586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42680337-42680839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42700904-42701445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42703016-42703552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14706 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42720960-42721165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42722188-42723064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42723065-42723940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10691 Neighboring gene death effector domain containing 2 Neighboring gene zinc finger protein 526

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol Transcription factors Oct-1, Oct-2, PU.1, Sp1, and Sp3 are recruited to the HS7 regulatory site in the pol coding region, suggesting that Oct-1, Oct-2, PU.1, Sp1, and Sp3 indirectly interact with HIV-1 Pol PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular response to virus  
    involved_in humoral immune response PubMed 
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    POU domain, class 2, transcription factor 2
    Names
    homeobox protein
    lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
    octamer-binding protein 2
    octamer-binding transcription factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030365.2 RefSeqGene

      Range
      70490..116826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207025.4 → NP_001193954.1  POU domain, class 2, transcription factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001193954.1

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Consensus CDS
      CCDS56095.1
      UniProtKB/Swiss-Prot
      P09086, Q16648, Q7M4M8, Q9BRS4
      Related
      ENSP00000431603.3, ENST00000526816.6
      Conserved Domains (3) summary
      smart00352
      Location:195 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:300 → 354
      Homeobox; Homeobox domain
      pfam09770
      Location:116 → 193
      PAT1; Topoisomerase II-associated protein PAT1
    2. NM_001207026.3 → NP_001193955.1  POU domain, class 2, transcription factor 2 isoform 3

      See identical proteins and their annotated locations for NP_001193955.1

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Consensus CDS
      CCDS56094.1
      Related
      ENSP00000436988.1, ENST00000529952.5
      Conserved Domains (2) summary
      smart00352
      Location:195 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:300 → 353
      Homeobox; Homeobox domain
    3. NM_001247994.3 → NP_001234923.1  POU domain, class 2, transcription factor 2 isoform 4

      See identical proteins and their annotated locations for NP_001234923.1

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Consensus CDS
      CCDS58665.1
      Related
      ENSP00000437224.1, ENST00000529067.5
      Conserved Domains (2) summary
      smart00352
      Location:179 → 253
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284 → 337
      Homeobox; Homeobox domain
    4. NM_001393934.1 → NP_001380863.1  POU domain, class 2, transcription factor 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Conserved Domains (2) summary
      smart00352
      Location:288 → 362
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:393 → 447
      Homeobox; Homeobox domain
    5. NM_001393935.1 → NP_001380864.1  POU domain, class 2, transcription factor 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      UniProtKB/TrEMBL
      H0YKT2
      Conserved Domains (2) summary
      smart00352
      Location:201 → 275
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:306 → 360
      Homeobox; Homeobox domain
    6. NM_001393936.1 → NP_001380865.1  POU domain, class 2, transcription factor 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Consensus CDS
      CCDS92629.1
      UniProtKB/TrEMBL
      B5ME60, H0YKT2
      Related
      ENSP00000339369.5, ENST00000342301.8
      Conserved Domains (2) summary
      smart00352
      Location:179 → 253
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284 → 338
      Homeobox; Homeobox domain
    7. NM_001394376.1 → NP_001381305.1  POU domain, class 2, transcription factor 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Consensus CDS
      CCDS92631.1
      UniProtKB/TrEMBL
      A0A8I5KYI8, H0YKT2
      Related
      ENSP00000509972.1, ENST00000692977.1
      Conserved Domains (3) summary
      smart00352
      Location:217 → 291
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:322 → 376
      Homeobox; Homeobox domain
      pfam09770
      Location:138 → 215
      PAT1; Topoisomerase II-associated protein PAT1
    8. NM_001394377.1 → NP_001381306.1  POU domain, class 2, transcription factor 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Conserved Domains (3) summary
      smart00352
      Location:294 → 368
      POU; Found in Pit-Oct-Unc transcription factors
      smart00389
      Location:396 → 452
      HOX; Homeodomain
      PRK10263
      Location:187 → 315
      PRK10263; DNA translocase FtsK; Provisional
    9. NM_001394378.1 → NP_001381307.1  POU domain, class 2, transcription factor 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Conserved Domains (2) summary
      smart00352
      Location:278 → 352
      POU; Found in Pit-Oct-Unc transcription factors
      smart00389
      Location:380 → 436
      HOX; Homeodomain
    10. NM_002698.6 → NP_002689.1  POU domain, class 2, transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_002689.1

      Status: REVIEWED

      Source sequence(s)
      AC010247, AC022515, AC024076
      Consensus CDS
      CCDS33035.1
      Related
      ENSP00000373992.3, ENST00000389341.9
      Conserved Domains (2) summary
      smart00352
      Location:179 → 253
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284 → 338
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42086110..42197936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438955.1 → XP_047294911.1  POU domain, class 2, transcription factor 2 isoform X4

    2. XM_047438954.1 → XP_047294910.1  POU domain, class 2, transcription factor 2 isoform X4

    3. XM_047438963.1 → XP_047294919.1  POU domain, class 2, transcription factor 2 isoform X10

      UniProtKB/TrEMBL
      H0YKT2
    4. XM_017026894.3 → XP_016882383.1  POU domain, class 2, transcription factor 2 isoform X12

      UniProtKB/TrEMBL
      H0YKT2
      Conserved Domains (3) summary
      smart00352
      Location:195 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:300 → 354
      Homeobox; Homeobox domain
      pfam09770
      Location:116 → 193
      PAT1; Topoisomerase II-associated protein PAT1
    5. XM_047438960.1 → XP_047294916.1  POU domain, class 2, transcription factor 2 isoform X8

      UniProtKB/TrEMBL
      H0YKT2
    6. XM_047438957.1 → XP_047294913.1  POU domain, class 2, transcription factor 2 isoform X5

    7. XM_017026892.3 → XP_016882381.1  POU domain, class 2, transcription factor 2 isoform X3

    8. XM_047438953.1 → XP_047294909.1  POU domain, class 2, transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      H0YKT2
    9. XM_011527042.4 → XP_011525344.1  POU domain, class 2, transcription factor 2 isoform X16

      UniProtKB/TrEMBL
      H0YLL6
      Related
      ENSP00000453255.1, ENST00000560398.5
      Conserved Domains (2) summary
      smart00352
      Location:201 → 275
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:306 → 360
      Homeobox; Homeobox domain
    10. XM_011527041.4 → XP_011525343.1  POU domain, class 2, transcription factor 2 isoform X15

      Conserved Domains (3) summary
      smart00352
      Location:217 → 291
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:322 → 376
      Homeobox; Homeobox domain
      pfam09770
      Location:138 → 215
      PAT1; Topoisomerase II-associated protein PAT1
    11. XM_047438958.1 → XP_047294914.1  POU domain, class 2, transcription factor 2 isoform X6

      UniProtKB/TrEMBL
      H0YKT2
      Related
      ENSP00000452930.2, ENST00000560804.6
    12. XM_017026891.3 → XP_016882380.1  POU domain, class 2, transcription factor 2 isoform X2

    13. XM_047438962.1 → XP_047294918.1  POU domain, class 2, transcription factor 2 isoform X9

      UniProtKB/TrEMBL
      H0YKT2
    14. XM_047438966.1 → XP_047294922.1  POU domain, class 2, transcription factor 2 isoform X14

      UniProtKB/TrEMBL
      H0YKT2
    15. XM_047438965.1 → XP_047294921.1  POU domain, class 2, transcription factor 2 isoform X13

      UniProtKB/TrEMBL
      H0YKT2
    16. XM_047438956.1 → XP_047294912.1  POU domain, class 2, transcription factor 2 isoform X4

    17. XM_047438964.1 → XP_047294920.1  POU domain, class 2, transcription factor 2 isoform X11

      UniProtKB/TrEMBL
      H0YKT2
    18. XM_047438959.1 → XP_047294915.1  POU domain, class 2, transcription factor 2 isoform X7

      UniProtKB/TrEMBL
      H0YKT2
    19. XM_047438961.1 → XP_047294917.1  POU domain, class 2, transcription factor 2 isoform X9

      UniProtKB/TrEMBL
      H0YKT2
    20. XM_047438968.1 → XP_047294924.1  POU domain, class 2, transcription factor 2 isoform X18

    21. XM_047438967.1 → XP_047294923.1  POU domain, class 2, transcription factor 2 isoform X17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44905480..45017310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321247.1 → XP_054177222.1  POU domain, class 2, transcription factor 2 isoform X4

    2. XM_054321246.1 → XP_054177221.1  POU domain, class 2, transcription factor 2 isoform X4

    3. XM_054321257.1 → XP_054177232.1  POU domain, class 2, transcription factor 2 isoform X12

      UniProtKB/TrEMBL
      H0YKT2
    4. XM_054321249.1 → XP_054177224.1  POU domain, class 2, transcription factor 2 isoform X5

    5. XM_054321245.1 → XP_054177220.1  POU domain, class 2, transcription factor 2 isoform X3

    6. XM_054321261.1 → XP_054177236.1  POU domain, class 2, transcription factor 2 isoform X16

    7. XM_054321260.1 → XP_054177235.1  POU domain, class 2, transcription factor 2 isoform X15

    8. XM_054321244.1 → XP_054177219.1  POU domain, class 2, transcription factor 2 isoform X2

    9. XM_054321258.1 → XP_054177233.1  POU domain, class 2, transcription factor 2 isoform X13

      UniProtKB/TrEMBL
      H0YKT2
    10. XM_054321248.1 → XP_054177223.1  POU domain, class 2, transcription factor 2 isoform X4

    11. XM_054321255.1 → XP_054177230.1  POU domain, class 2, transcription factor 2 isoform X10

      UniProtKB/TrEMBL
      H0YKT2
    12. XM_054321252.1 → XP_054177227.1  POU domain, class 2, transcription factor 2 isoform X8

      UniProtKB/TrEMBL
      H0YKT2
    13. XM_054321243.1 → XP_054177218.1  POU domain, class 2, transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      H0YKT2
    14. XM_054321250.1 → XP_054177225.1  POU domain, class 2, transcription factor 2 isoform X6

      UniProtKB/TrEMBL
      H0YKT2
    15. XM_054321254.1 → XP_054177229.1  POU domain, class 2, transcription factor 2 isoform X9

      UniProtKB/TrEMBL
      H0YKT2
    16. XM_054321259.1 → XP_054177234.1  POU domain, class 2, transcription factor 2 isoform X14

      UniProtKB/TrEMBL
      H0YKT2
    17. XM_054321251.1 → XP_054177226.1  POU domain, class 2, transcription factor 2 isoform X7

      UniProtKB/TrEMBL
      H0YKT2
    18. XM_054321253.1 → XP_054177228.1  POU domain, class 2, transcription factor 2 isoform X9

      UniProtKB/TrEMBL
      H0YKT2
    19. XM_054321256.1 → XP_054177231.1  POU domain, class 2, transcription factor 2 isoform X11

      UniProtKB/TrEMBL
      H0YKT2
    20. XM_054321262.1 → XP_054177237.1  POU domain, class 2, transcription factor 2 isoform X17

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