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E6 transforming protein [ Human papillomavirus 5 ]

Gene ID: 1489047, updated on 18-Aug-2023

Summary

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Gene symbol
E6
Gene description
transforming protein
Locus tag
HpV5gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human papillomavirus 5
Lineage
Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus
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Genomic context

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Sequence:
NC_001531.1 (200..673)

NC_001531.1Genomic Context describing neighboring genes Neighboring gene transforming protein Neighboring gene replication protein Neighboring gene regulatory protein Neighboring gene E4 Neighboring gene E5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001531.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability. Wallace NA, et al. J Virol, 2014 Jun. PMID 24648447, Free PMC Article
  2. A conserved C-terminal sequence of high-risk cutaneous beta-human papillomavirus E6 proteins alters localization and signalling of β1-integrin to promote cell migration. Holloway A, et al. J Gen Virol, 2014 Jan. PMID 24154967
  3. Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3. Mendoza JA, et al. J Virol, 2006 Dec. PMID 17020941, Free PMC Article
  4. High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression. Poirson J, et al. J Virol, 2022 May 25. PMID 35475668, Free PMC Article
  5. HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition. Wallace NA, et al. Virology, 2013 Aug 15. PMID 23706308, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.
    Title: High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.
  2. The authors show an interaction of Human papillomaviruses 5 and 8 oncoproteins E6 and E7 with the nuclear mitotic apparatus protein 1 (NuMA).
    Title: BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes.
  3. this work establishes an expanded ability of beta-HPV 5 and 8 E6 to attenuate UV damage repair
    Title: β-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation.
  4. Data show that E3 ubiquitin-protein ligase HERC1 interacts with bcl-2 homologous antagonist-killer protein BAK in HPV5 E6-expressing cells that have been damaged by UV.
    Title: Resistance to UV-induced apoptosis by β-HPV5 E6 involves targeting of activated BAK for proteolysis by recruitment of the HERC1 ubiquitin ligase.
  5. Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability.
    Title: Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability.
  6. The C-terminal sequence of papillomavirus 5 E6 proteins alters localization and signalling of beta1-integrin to promote cell migration.
    Title: A conserved C-terminal sequence of high-risk cutaneous beta-human papillomavirus E6 proteins alters localization and signalling of β1-integrin to promote cell migration.
  7. Authors show that human papillomavirus type 5 and 8 E6 are capable of reducing the steady state levels of another p53 modifying enzyme, ATM, and as a result restrict LINE-1 retrotransposition.
    Title: HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition.
  8. data demonstrate that beta-HPV E6 expression can enhance the carcinogenic potential of UVB exposure by promoting p300 degradation, resulting in a reduction in ATR levels, which leads to increased thymine dimer persistence and increased UVB induced double strand breaks
    Title: HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.
  9. Beta-HPV 5 and 8 E6 degrade p300 in a proteasomal-dependent, E6AP-independent manner. E6 competes with AKT for binding to p300.
    Title: Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association.
  10. Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3.
    Title: Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
transforming protein
NP_041365.1
  • putative

VOG classification

Description:

  • VOGd0194 [R] Early oncoprotein E6
  • Regulation of Cellular Metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001531.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_041365.1 transforming protein [Human papillomavirus 5]

    See identical proteins and their annotated locations for NP_041365.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06930, P26556
    UniProtKB/TrEMBL
    Q6LBH6, Q76WJ7
    Conserved Domains (1) summary
    pfam00518
    Location:41 → 150
    E6; Early Protein (E6)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06930.2

Gene LinkOut

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Molecular Biology Databases
Research Materials