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    Piga phosphatidylinositol glycan anchor biosynthesis, class A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363464, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Pigaprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Aprovided by RGD
    Primary source
    RGD:1589723
    See related
    EnsemblRapid:ENSRNOG00000003554 AllianceGenome:RGD:1589723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 44.6), Kidney (RPKM 41.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Piga in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33672832..33687747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30043033..30055861, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31786823..31799751, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 9 Neighboring gene ankyrin repeat and SOCS box containing 11 Neighboring gene vascular endothelial growth factor D Neighboring gene ubiquitin-conjugating enzyme E2 K pseudogene Neighboring gene pirin Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay. Dad A, et al. Mutat Res Genet Toxicol Environ Mutagen, 2020 Oct-Dec. PMID 33198937
    2. Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa. Labash C, et al. Mutat Res Genet Toxicol Environ Mutagen, 2015 Apr. PMID 25868128, Free PMC Article
    3. Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays. Avlasevich SL, et al. Environ Mol Mutagen, 2014 Jun. PMID 24574022
    4. Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone. Dertinger SD, et al. Environ Mol Mutagen, 2014 May. PMID 24449360
    5. Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds. Dertinger SD, et al. Toxicol Sci, 2012 Dec. PMID 22923490, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay.
      Title: Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay.
    2. Data suggest the use of both sexes for phosphatidylinositolglycan class A protein Pig-a gene mutation studies.
      Title: Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.
    3. Pig-a mutation is associated with diethylnitrosamine genotoxicity.
      Title: Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.
    4. Pig-a gene mutation is associated with micronucleated reticulocyte induction.
      Title: Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.
    5. Data demonstrate the value of integrating Pig-a mutation and micronucleus endpoints into in vivo toxicology studies.
      Title: Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit A
    Names
    N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
    phosphatidylinositol glycan, class A
    NP_001102286.1
    NP_001387965.1
    XP_006256932.1
    XP_006256935.1
    XP_006256938.1
    XP_038955802.1
    XP_038955803.1
    XP_038955804.1
    XP_038955807.1
    XP_038955808.1
    XP_038955811.1
    XP_038955813.1
    XP_038955814.1
    XP_038955816.1
    XP_038955817.1
    XP_063136197.1
    XP_063136198.1
    XP_063136199.1
    XP_063136200.1
    XP_063136201.1
    XP_063136202.1
    XP_063136203.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108816.2 → NP_001102286.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform 2

      Status: VALIDATED

      Source sequence(s)
      CH474014
      UniProtKB/TrEMBL
      A6K2K6
      Related
      ENSRNOP00000045342.5, ENSRNOT00000044103.7
      Conserved Domains (1) summary
      cl10013
      Location:5 → 200
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    2. NM_001401036.1 → NP_001387965.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4AAY7
      Related
      ENSRNOP00000091008.2, ENSRNOT00000107804.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      33672832..33687747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099876.2 → XP_038955804.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    2. XM_063280129.1 → XP_063136199.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7

    3. XM_039099874.2 → XP_038955802.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    4. XM_063280128.1 → XP_063136198.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7

    5. XM_063280133.1 → XP_063136203.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

      UniProtKB/TrEMBL
      A6K2K6

    6. XM_063280132.1 → XP_063136202.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4

    7. XM_039099886.2 → XP_038955814.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

      UniProtKB/TrEMBL
      A6K2K6
      Conserved Domains (1) summary
      cl10013
      Location:5 → 200
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    8. XM_006256873.5 → XP_006256935.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    9. XM_039099888.2 → XP_038955816.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

      UniProtKB/TrEMBL
      A6K2K6
      Conserved Domains (1) summary
      cl10013
      Location:5 → 200
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    10. XM_039099879.2 → XP_038955807.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    11. XM_039099875.2 → XP_038955803.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    12. XM_006256876.3 → XP_006256938.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    13. XM_039099889.2 → XP_038955817.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

      UniProtKB/TrEMBL
      A6K2K6
      Conserved Domains (1) summary
      cl10013
      Location:5 → 200
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    14. XM_063280127.1 → XP_063136197.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7

    15. XM_006256870.4 → XP_006256932.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    16. XM_039099880.2 → XP_038955808.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

      UniProtKB/TrEMBL
      D4AAY7
      Conserved Domains (1) summary
      cd03796
      Location:34 → 433
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

    17. XM_039099885.2 → XP_038955813.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4

      Conserved Domains (1) summary
      cl10013
      Location:12 → 208
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    18. XM_039099883.2 → XP_038955811.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4

      Conserved Domains (1) summary
      cl10013
      Location:12 → 208
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    19. XM_063280130.1 → XP_063136200.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X2

    20. XM_063280131.1 → XP_063136201.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X3

      UniProtKB/TrEMBL
      A0A8I6AMH9

    RNA

    1. XR_005498009.2 RNA Sequence

    2. XR_005498007.2 RNA Sequence

    3. XR_005498010.2 RNA Sequence

    4. XR_005498008.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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