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Conserved domains on  [gi|1958807770|ref|XP_038955813|]
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phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4 [Rattus norvegicus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 12-208 2.20e-111

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03796:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 398  Bit Score: 326.12  E-value: 2.20e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFC 91
Cdd:cd03796   204 YRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFC 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  92 MAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQVKSGTlPAPENIHNVVKTFYTWRNVAERTE 171
Cdd:cd03796   284 IAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTE 362

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958807770 172 KVYERVSKESVLPMHKRLdRLISHCGPVTGYIFALLA 208
Cdd:cd03796   363 KVYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 12-208 2.20e-111

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 326.12  E-value: 2.20e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFC 91
Cdd:cd03796   204 YRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFC 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  92 MAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQVKSGTlPAPENIHNVVKTFYTWRNVAERTE 171
Cdd:cd03796   284 IAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTE 362

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958807770 172 KVYERVSKESVLPMHKRLdRLISHCGPVTGYIFALLA 208
Cdd:cd03796   363 KVYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
12-139 4.24e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 86.03  E-value: 4.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVREryqLHDRVQLLGALEhkDVRNVLVQGHIFLNTSLTEAFC 91
Cdd:pfam13692  13 NVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFG 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958807770  92 MAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 139
Cdd:pfam13692  88 LKLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 79-179 6.06e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 69.25  E-value: 6.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  79 HIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAIfqvKSGTLPA--PENIH 154
Cdd:COG0438    22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRLL---EDPELRRrlGEAAR 98

                          90       100
                  ....*....|....*....|....*
gi 1958807770 155 NVVKTFYTWRNVAERTEKVYERVSK 179
Cdd:COG0438    99 ERAEERFSWEAIAERLLALYEELLA 123
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
9-175 6.70e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 46.71  E-value: 6.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGE------GPKRIILEEVRE-RYQLHDRVQLLGALEHKDVRNVL-VQGHI 80
Cdd:PRK15484  201 RISPDKGILLLMQAFEKLATAHSNLKLVVVGDptasskGEKAAYQKKVLEaAKRIGDRCIMLGGQPPEKMHNYYpLADLV 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  81 FLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPENLI--ILCEP-SVKSLCEGLEKAIFQVKSGTLpaPENIHNVV 157
Cdd:PRK15484  281 VVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTLADPELTQI--AEQAKDFV 358

                         170
                  ....*....|....*...
gi 1958807770 158 KTFYTWRNVAERTEKVYE 175
Cdd:PRK15484  359 FSKYSWEGVTQRFEEQIH 376
sucrsPsyn_pln TIGR02468
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ...
 80-122 3.14e-03

sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein.


Pssm-ID: 274147 [Multi-domain]  Cd Length: 1050  Bit Score: 38.61  E-value: 3.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958807770   80 IFLNTSLTEAFCMAIVEAASCGLQVVSTKVGG---IPEVLPENLII 122
Cdd:TIGR02468  574 VFINPAFIEPFGLTLIEAAAHGLPMVATKNGGpvdIHRVLDNGLLV 619
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 12-208 2.20e-111

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 326.12  E-value: 2.20e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFC 91
Cdd:cd03796   204 YRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFC 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  92 MAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQVKSGTlPAPENIHNVVKTFYTWRNVAERTE 171
Cdd:cd03796   284 IAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTE 362

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958807770 172 KVYERVSKESVLPMHKRLdRLISHCGPVTGYIFALLA 208
Cdd:cd03796   363 KVYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 9-175 3.04e-24

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 99.53  E-value: 3.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLI-GGEGPKRiilEEVRER-YQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSL 86
Cdd:cd03801   200 RLSPRKGVDLLLEALAKLLRRGPDVRLVIvGGDGPLR---AELEELeLGLGDRVRFLGFVPDEELPALYAAADVFVLPSR 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  87 TEAFCMAIVEAASCGLQVVSTKVGGIPEVLP--ENLIILCEPSVKSLCEGLEKAIfqvKSGTLPAP--ENIHNVVKTFYT 162
Cdd:cd03801   277 YEGFGLVVLEAMAAGLPVVATDVGGLPEVVEdgEGGLVVPPDDVEALADALLRLL---ADPELRARlgRAARERVAERFS 353

                         170
                  ....*....|...
gi 1958807770 163 WRNVAERTEKVYE 175
Cdd:cd03801   354 WERVAERLLDLYR 366
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
12-139 4.24e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 86.03  E-value: 4.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVREryqLHDRVQLLGALEhkDVRNVLVQGHIFLNTSLTEAFC 91
Cdd:pfam13692  13 NVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFG 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958807770  92 MAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 139
Cdd:pfam13692  88 LKLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 9-139 1.71e-19

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 82.32  E-value: 1.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTE 88
Cdd:pfam00534  10 RLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958807770  89 AFCMAIVEAASCGLQVVSTKVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAI 139
Cdd:pfam00534  90 GFGIVLLEAMACGLPVIASDVGGPPEVVKDGETgFLVKPnNAEALAEAIDKLL 142
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 11-177 1.02e-17

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 81.66  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  11 SPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAF 90
Cdd:cd03798   210 IPRKGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGF 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  91 CMAIVEAASCGLQVVSTKVGGIPEVL-PENLIILCEP-SVKSLCEGLEKAIFQVKSGTLPApENIHNVVKTFyTWRNVAE 168
Cdd:cd03798   290 GLVLLEAMACGLPVVATDVGGIPEVVgDPETGLLVPPgDADALAAALRRALAEPYLRELGE-AARARVAERF-SWVKAAD 367


                  ....*....
gi 1958807770 169 RTEKVYERV 177
Cdd:cd03798   368 RIAAAYRDV 376
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 9-139 1.89e-17

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 80.44  E-value: 1.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTE 88
Cdd:cd03807   198 RLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERLLLELGLEDRVHLLG--ERSDVPALLPAMDIFVLSSRTE 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958807770  89 AFCMAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 139
Cdd:cd03807   276 GFPNALLEAMACGLPVVATDVGGAAELVDDGTGFLVPAgDPQALADAIRALL 327
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 11-119 1.28e-16

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 76.67  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  11 SPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQG-HIFLNTSLTEA 89
Cdd:cd01635   120 VPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAaDVFVLPSRSEG 199

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958807770  90 FCMAIVEAASCGLQVVSTKVGGIPEVLPEN 119
Cdd:cd01635   200 FGLVLLEAMAAGKPVIATDVGGIPEFVVDG 229
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 79-179 6.06e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 69.25  E-value: 6.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  79 HIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAIfqvKSGTLPA--PENIH 154
Cdd:COG0438    22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRLL---EDPELRRrlGEAAR 98

                          90       100
                  ....*....|....*....|....*
gi 1958807770 155 NVVKTFYTWRNVAERTEKVYERVSK 179
Cdd:COG0438    99 ERAEERFSWEAIAERLLALYEELLA 123
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 9-143 1.97e-14

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 72.01  E-value: 1.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTE 88
Cdd:cd03811   196 RLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGLAERVIFLG--FQSNPYPYLKKADLFVLSSRYE 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958807770  89 AFCMAIVEAASCGLQVVSTKVGGIPEVLPENL-IILCEPSVKSLCEGLEKAIFQVK 143
Cdd:cd03811   274 GFPNVLLEAMALGTPVVSTDCPGPREILDDGEnGLLVPDGDAAALAGILAALLQKK 329
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 28-139 1.51e-13

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 69.16  E-value: 1.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  28 QKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 107
Cdd:cd03808   216 KKGPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLG--FRSDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITT 293

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958807770 108 KVGGIPE-VLPENLIILCEP-SVKSLCEGLEKAI 139
Cdd:cd03808   294 DVPGCRElVIDGVNGFLVPPgDVEALADAIEKLI 327
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 39-119 4.95e-13

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 67.76  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  39 GEGPKRIILEEVRERYQLHDRVQLLGALEHkdVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPE 118
Cdd:cd04962   233 GDGPERVPAEELARELGVEDRVLFLGKQDD--VEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKH 310


                  .
gi 1958807770 119 N 119
Cdd:cd04962   311 G 311
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 35-126 6.13e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 67.38  E-value: 6.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  35 FLIGGEGPKRIILEEVRERYQLHDRVQLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPE 114
Cdd:cd03819   215 LLVAGDGPERDEIRRLVERLGLRDRVTFTGF--REDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGARE 292

                          90
                  ....*....|..
gi 1958807770 115 VLPENLIILCEP 126
Cdd:cd03819   293 IVVHGRTGLLVP 304
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 12-171 1.31e-12

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 66.88  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLL---SGIIPELcqkYQELNFLIGGeGPKRIILEEVRE-------RYQLHDRVQLLGALEHKDVRNVLVQGHIF 81
Cdd:cd03800   231 PRKGIDTLvraFAQLPEL---RELANLVLVG-GPSDDPLSMDREelaelaeELGLIDRVRFPGRVSRDDLPELYRAADVF 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  82 LNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPE-VLPENLIILCEP-SVKSLCEGLEKaIFQVKSGTLPAPENIHNVVKT 159
Cdd:cd03800   307 VVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDiVRDGRTGLLVDPhDPEALAAALRR-LLDDPALWQRLSRAGLERARA 385

                         170
                  ....*....|..
gi 1958807770 160 FYTWRNVAERTE 171
Cdd:cd03800   386 HYTWESVADQLL 397
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 23-122 1.85e-12

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 66.31  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  23 IPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGL 102
Cdd:cd04951   210 ISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQ--ISNISEYYNAADLFVLSSEWEGFGLVVAEAMACER 287

                          90       100
                  ....*....|....*....|.
gi 1958807770 103 QVVSTKVGGIPEVL-PENLII 122
Cdd:cd04951   288 PVVATDAGGVAEVVgDHNYVV 308
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 35-177 1.02e-11

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 63.84  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  35 FLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPE 114
Cdd:cd03817   234 LVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASE 313

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807770 115 VLpENLI--ILCEPSVKSLCEGLEKAIFQVKSGTLPApENIHNVVKTFytwrNVAERTEKVYERV 177
Cdd:cd03817   314 LV-EDGEngFLFEPNDETLAEKLLHLRENLELLRKLS-KNAEISAREF----AFAKSVEKLYEEV 372
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 15-106 3.10e-11

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 62.64  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  15 GTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALehKDVRNVLVQGHIFLNTSLTEAFCMAI 94
Cdd:cd03820   195 GFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPT--KNIAEEYANSSIFVLSSRYEGFPMVL 272

                          90
                  ....*....|..
gi 1958807770  95 VEAASCGLQVVS 106
Cdd:cd03820   273 LEAMAYGLPIIS 284
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 26-120 3.81e-11

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 62.08  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  26 LCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLT------EAFCMAIVEAAS 99
Cdd:cd03799   199 LAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMA 278

                          90       100
                  ....*....|....*....|.
gi 1958807770 100 CGLQVVSTKVGGIPEVLPENL 120
Cdd:cd03799   279 MGLPVISTEHGGIPELVEDGV 299
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 36-172 4.11e-10

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 59.30  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  36 LIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEV 115
Cdd:cd03809   228 IVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEV 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958807770 116 LPENlIILCEP-SVKSLCEGLEKAIFQvKSGTLPAPENIHNVVKTFyTWRNVAERTEK 172
Cdd:cd03809   308 AGDA-ALYFDPlDPESIADAILRLLED-PSLREELIRKGLERAKKF-SWEKTAEKTLE 362
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 9-114 1.58e-09

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 57.46  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYqlhDRVQLLGALEHKDVRNVLVQGHIFLNTSLT- 87
Cdd:cd05844   197 RLVEKKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAAL---GRVRFLGALPHAEVQDWMRRAEIFCLPSVTa 273

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958807770  88 -----EAFCMAIVEAASCGLQVVSTKVGGIPE 114
Cdd:cd05844   274 asgdsEGLGIVLLEAAACGVPVVSSRHGGIPE 305
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 17-139 4.98e-09

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 55.93  E-value: 4.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  17 DLLSGIIPELCQKYQELNFL---IGGeGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQG--HIFLNTSLTEAFC 91
Cdd:cd04946   240 DLIIETLNSLCVAHPSICISwthIGG-GPLKERLEKLAENKLENVKVNFTGEVSNKEVKQLYKENdvDVFVNVSESEGIP 318

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958807770  92 MAIVEAASCGLQVVSTKVGGIPEVLpEN----LIILCEPSVKSLCEGLEKAI 139
Cdd:cd04946   319 VSIMEAISFGIPVIATNVGGTREIV-ENetngLLLDKDPTPNEIVSSIMKFY 369
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 12-171 6.00e-09

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 55.84  E-value: 6.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  12 PREGTDLLSGIIPELCQKYQELNFLIGGEGPKriiLEEVRERYQ----LHDRVQLLGALEHKDVRNVLVQGHIFLNTSLT 87
Cdd:cd03821   215 PKKGLDLLIRAARKLAEQGRDWHLVIAGPDDG---AYPAFLQLQsslgLGDRVTFTGPLYGEAKWALYASADLFVLPSYS 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  88 EAFCMAIVEAASCGLQVVSTKVGGIPEVLPENLIILCEPSVKSLCEGLEKAIfQVKSGTLPAPENIHNVVKT--FYTWRN 165
Cdd:cd03821   292 ENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEAL-RDPADRKRLGEMARRARQVeeNFSWEA 370


                  ....*.
gi 1958807770 166 VAERTE 171
Cdd:cd03821   371 VAGQLG 376
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 31-111 3.15e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 53.43  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  31 QELNF--LIGGEGPKRIILEEVRErYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSL--TEAFCMAIVEAASCGLQVVS 106
Cdd:cd03795   214 QYLNYpiVIGGEGPLKPDLEAQIE-LNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVIS 292


                  ....*
gi 1958807770 107 TKVGG 111
Cdd:cd03795   293 TNIGT 297
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 9-118 9.33e-08

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 52.30  E-value: 9.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKyQELNFLIGGEGPKRiilEEVRERYqlhDRVQLLGALEHKDVRNVLVQGHIFLNTSLTE 88
Cdd:cd03814   206 RLAPEKNLEALLDADLPLAAS-PPVRLVVVGDGPAR---AELEARG---PDVIFTGFLTGEELARAYASADVFVFPSRTE 278

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958807770  89 AFCMAIVEAASCGLQVVSTKVGGIPEVLPE 118
Cdd:cd03814   279 TFGLVVLEAMASGLPVVAADAGGPRDIVRP 308
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 9-109 1.83e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 48.07  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGEGPKRIILEEVRERYQLHDRVQLLGAleHKDVRNVLVQGHIFLNTSLTE 88
Cdd:cd04949   168 RLAPEKQLDHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGY--HSNLDQEYQDAYLSLLTSQME 245

                          90       100
                  ....*....|....*....|.
gi 1958807770  89 AFCMAIVEAASCGLQVVSTKV 109
Cdd:cd04949   246 GFGLTLMEAIGHGLPVVSYDV 266
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 11-176 3.16e-06

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 47.71  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  11 SPREGTDLLSGIIPELcqKYQELNFLIGGEGPKRIIleevrERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSL-TEA 89
Cdd:cd03823   201 TEEKGIDLLVEAFKRL--PREDIELVIAGHGPLSDE-----RQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEP 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  90 FCMAIVEAASCGLQVVSTKVGGIPE-VLPENLIILCEPSVKslcEGLEKAIFQV-KSGTLPAPENIHNVVKTFYTWRnvA 167
Cdd:cd03823   274 FGLVVREAIAAGLPVIASDLGGIAElIQPGVNGLLFAPGDA---EDLAAAMRRLlTDPALLERLRAGAEPPRSTESQ--A 348


                  ....*....
gi 1958807770 168 ERTEKVYER 176
Cdd:cd03823   349 EEYLKLYRD 357
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
9-175 6.70e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 46.71  E-value: 6.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770   9 RNSPREGTDLLSGIIPELCQKYQELNFLIGGE------GPKRIILEEVRE-RYQLHDRVQLLGALEHKDVRNVL-VQGHI 80
Cdd:PRK15484  201 RISPDKGILLLMQAFEKLATAHSNLKLVVVGDptasskGEKAAYQKKVLEaAKRIGDRCIMLGGQPPEKMHNYYpLADLV 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  81 FLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPENLI--ILCEP-SVKSLCEGLEKAIFQVKSGTLpaPENIHNVV 157
Cdd:PRK15484  281 VVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTLADPELTQI--AEQAKDFV 358

                         170
                  ....*....|....*...
gi 1958807770 158 KTFYTWRNVAERTEKVYE 175
Cdd:PRK15484  359 FSKYSWEGVTQRFEEQIH 376
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 36-116 2.41e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 45.02  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  36 LIGGEGPKRIILEEVRERYQ---LHDRVQLLGaleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGI 112
Cdd:cd03813   329 LIGPEDEDPEYAQECKRLVAslgLENKVKFLG---FQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSC 405


                  ....
gi 1958807770 113 PEVL 116
Cdd:cd03813   406 RELI 409
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 36-136 3.08e-05

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 44.63  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  36 LIGGEGPKRIILE-EVRERYQLHDRVQLlgalehkdvRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPE 114
Cdd:cd03825   230 VFGKNDPQIVILPfDIISLGYIDDDEQL---------VDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPE 300

                          90       100
                  ....*....|....*....|....
gi 1958807770 115 VL--PENLIILCEPSVKSLCEGLE 136
Cdd:cd03825   301 IVqhGVTGYLVPPGDVQALAEAIE 324
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 58-177 1.48e-04

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 42.27  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807770  58 DRVQLLGALEHKDVRNVLVQGHIFLNTSL-TEAFCMAIVEAASCGLQVVSTKVGGIPEVLPENLI-ILCEPSvkslcEGL 135
Cdd:cd03802   220 PRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETgFLVDSV-----EEM 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958807770 136 EKAIFQVksGTLPaPENIHNVVKTFYTWRNVAERTEKVYERV 177
Cdd:cd03802   295 AEAIANI--DRID-RAACRRYAEDRFSAARMADRYEALYRKV 333
sucrsPsyn_pln TIGR02468
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ...
 80-122 3.14e-03

sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein.


Pssm-ID: 274147 [Multi-domain]  Cd Length: 1050  Bit Score: 38.61  E-value: 3.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958807770   80 IFLNTSLTEAFCMAIVEAASCGLQVVSTKVGG---IPEVLPENLII 122
Cdd:TIGR02468  574 VFINPAFIEPFGLTLIEAAAHGLPMVATKNGGpvdIHRVLDNGLLV 619
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 39-105 8.85e-03

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 36.88  E-value: 8.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958807770  39 GEGPKRI-ILEEVRERyQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVV 105
Cdd:cd03812   229 GEGELKEkIKEKVKEL-GLEDKVIFLG--FRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCL 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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