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    Lrrc23 leucine rich repeat containing 23 [ Mus musculus (house mouse) ]

    Gene ID: 16977, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc23provided by MGI
    Official Full Name
    leucine rich repeat containing 23provided by MGI
    Primary source
    MGI:MGI:1315192
    See related
    Ensembl:ENSMUSG00000030125 AllianceGenome:MGI:1315192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B7; Lrpb7; 4921537K05Rik
    Summary
    Involved in flagellated sperm motility and radial spoke assembly. Located in sperm flagellum. Is active in cytosol. Is expressed in lung; lung epithelium; nasal cavity respiratory epithelium; nasal epithelium; and palatal shelf mesenchyme. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 29.6), lung adult (RPKM 7.1) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc23 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124746832..124757411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124769869..124780438, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8991 Neighboring gene atrophin 1 Neighboring gene STARR-seq mESC enhancer starr_17303 Neighboring gene enolase 2, gamma neuronal Neighboring gene predicted gene, 38895 Neighboring gene STARR-seq mESC enhancer starr_17308 Neighboring gene predicted gene, 38894 Neighboring gene STARR-positive B cell enhancer ABC_E2803 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. Hwang JY, et al. Elife, 2023 Dec 13. PMID 38091523, Free PMC Article
    2. LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice. Zhang X, et al. J Cell Sci, 2021 Oct 15. PMID 34585727, Free PMC Article
    3. Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis. Piña JO, et al. Nat Commun, 2023 Sep 14. PMID 37709732, Free PMC Article
    4. Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Ansari-Lari MA, et al. Genome Res, 1998 Jan. PMID 9445485
    5. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility.
      Title: LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility.
    2. LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.
      Title: LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.
    3. Lrrc23 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in radial spoke assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 23
    Names
    leucine-rich protein B7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302555.1 → NP_001289484.1  leucine-rich repeat-containing protein 23

      See identical proteins and their annotated locations for NP_001289484.1

      Status: VALIDATED

      Source sequence(s)
      AW122764, BC049601
      Consensus CDS
      CCDS20528.1
      UniProtKB/Swiss-Prot
      O35125
      Related
      ENSMUSP00000108094.3, ENSMUST00000112475.9
      Conserved Domains (2) summary
      sd00033
      Location:70 → 89
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:75 → 281
      internalin_A; class 1 internalin InlA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124746832..124757411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241240.4 → XP_011239542.1  leucine-rich repeat-containing protein 23 isoform X2

      See identical proteins and their annotated locations for XP_011239542.1

      UniProtKB/Swiss-Prot
      O35125
      Conserved Domains (2) summary
      sd00033
      Location:70 → 89
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:75 → 281
      internalin_A; class 1 internalin InlA

    2. XM_006505659.5 → XP_006505722.1  leucine-rich repeat-containing protein 23 isoform X2

      See identical proteins and their annotated locations for XP_006505722.1

      UniProtKB/Swiss-Prot
      O35125
      Conserved Domains (2) summary
      sd00033
      Location:70 → 89
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:75 → 281
      internalin_A; class 1 internalin InlA

    3. XM_006505658.5 → XP_006505721.1  leucine-rich repeat-containing protein 23 isoform X1

      Conserved Domains (2) summary
      sd00033
      Location:100 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:105 → 311
      internalin_A; class 1 internalin InlA

    4. XM_006505660.5 → XP_006505723.1  leucine-rich repeat-containing protein 23 isoform X2

      See identical proteins and their annotated locations for XP_006505723.1

      UniProtKB/Swiss-Prot
      O35125
      Conserved Domains (2) summary
      sd00033
      Location:70 → 89
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:75 → 281
      internalin_A; class 1 internalin InlA

    5. XM_011241239.3 → XP_011239541.1  leucine-rich repeat-containing protein 23 isoform X2

      See identical proteins and their annotated locations for XP_011239541.1

      UniProtKB/Swiss-Prot
      O35125
      Related
      ENSMUSP00000032218.4, ENSMUST00000032218.10
      Conserved Domains (2) summary
      sd00033
      Location:70 → 89
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:75 → 281
      internalin_A; class 1 internalin InlA

    6. XM_006505663.5 → XP_006505726.1  leucine-rich repeat-containing protein 23 isoform X2

      See identical proteins and their annotated locations for XP_006505726.1

      UniProtKB/Swiss-Prot
      O35125
      Conserved Domains (2) summary
      sd00033
      Location:70 → 89
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:75 → 281
      internalin_A; class 1 internalin InlA

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013588.1: Suppressed sequence

      Description
      NM_013588.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35125.1 GenPept UniProtKB/Swiss-Prot:O35125

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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