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Conserved domains on  [gi|755516220|ref|XP_011239542|]
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leucine-rich repeat-containing protein 23 isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1908540)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 157-301 6.51e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 6.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 157 LDLKGNRIHQVTGLdpERLSSLHTLELRGNQLESTKGI-YLPKLKNLYLAQNLLKKVEGLENLSNLTTLHL--------- 226
Cdd:cd21340   29 LYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlppge 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 227 ---------------------RDNQIETLNGFSqEMKSLQYLNLRSNMISDLAELAK-LRDLPKLRALVLLDNPCADETD 284
Cdd:cd21340  107 kltfdprslaalsnslrvlniSGNNIDSLEPLA-PLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPK 185

                        170
                 ....*....|....*..
gi 755516220 285 YRQEALVQMAHLERLDK 301
Cdd:cd21340  186 YRDKIILASKSLEVLDG 202
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
70-236 1.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  70 KLEAKDRDLTDISL-LRSYIHLRYVDISENHITDIS-PLNSLTHLLWLKADGNQLRS--ARMNELPYLQIASFSYNQIID 145
Cdd:COG4886  163 SLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDlpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 146 TEGIFH-PRLGSLDLKGNRIhqvTGLDPE-RLSSLHTLELRGNQLESTKGIYLPKLKNLYLAQNLLKKVEGLENLSNLTT 223
Cdd:COG4886  243 LPELGNlTNLEELDLSNNQL---TDLPPLaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                        170
                 ....*....|...
gi 755516220 224 LHLRDNQIETLNG 236
Cdd:COG4886  320 LTTLLLLLLLLKG 332
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 157-301 6.51e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 6.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 157 LDLKGNRIHQVTGLdpERLSSLHTLELRGNQLESTKGI-YLPKLKNLYLAQNLLKKVEGLENLSNLTTLHL--------- 226
Cdd:cd21340   29 LYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlppge 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 227 ---------------------RDNQIETLNGFSqEMKSLQYLNLRSNMISDLAELAK-LRDLPKLRALVLLDNPCADETD 284
Cdd:cd21340  107 kltfdprslaalsnslrvlniSGNNIDSLEPLA-PLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPK 185

                        170
                 ....*....|....*..
gi 755516220 285 YRQEALVQMAHLERLDK 301
Cdd:cd21340  186 YRDKIILASKSLEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-285 2.85e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  78 LTDI-SLLRSYIHLRYVDISENHITDI-SPLNSLTHLLWLKADGNQLRS--ARMNELPYLQIASFSYNQIIDTEGIFH-- 151
Cdd:COG4886  125 LTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlpEELGNLTNLKELDLSNNQITDLPEPLGnl 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 152 PRLGSLDLKGNRIhqvTGLDPE--RLSSLHTLELRGNQLESTKGI-YLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRD 228
Cdd:COG4886  205 TNLEELDLSGNQL---TDLPEPlaNLTNLETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSN 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755516220 229 NQIETLNGFSQEMKSLQYLNLRSNMISDLAELAKLRDLPKLRALVLLDNPCADETDY 285
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR_9 pfam14580
Leucine-rich repeat;
181-314 1.22e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  181 LELRGNQLESTK--GIYLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETLN-GFSQEMKSLQYLNLRSNMISDL 257
Cdd:pfam14580  24 LDLRGYKIPIIEnlGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGeGLGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755516220  258 AELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLDKEFYEDDDRAEAEE 314
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-236 1.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  70 KLEAKDRDLTDISL-LRSYIHLRYVDISENHITDIS-PLNSLTHLLWLKADGNQLRS--ARMNELPYLQIASFSYNQIID 145
Cdd:COG4886  163 SLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDlpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 146 TEGIFH-PRLGSLDLKGNRIhqvTGLDPE-RLSSLHTLELRGNQLESTKGIYLPKLKNLYLAQNLLKKVEGLENLSNLTT 223
Cdd:COG4886  243 LPELGNlTNLEELDLSNNQL---TDLPPLaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                        170
                 ....*....|...
gi 755516220 224 LHLRDNQIETLNG 236
Cdd:COG4886  320 LTTLLLLLLLLKG 332
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-299 5.54e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 5.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  80 DISLLRSyiHLRYVDISENHITDISPLNSLTHLLWLKADGNQLrSARMnelpYLQIASFSynqiidtegifhpRLGSLDL 159
Cdd:PLN00113 112 DIFTTSS--SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNML-SGEI----PNDIGSFS-------------SLKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 160 KGNRIHQVTGLDPERLSSLHTLELRGNQLESTKGIYLPKLKNL---YLAQNLL-----KKVEGLENLSNLTTLHlrDNQI 231
Cdd:PLN00113 172 GGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLkwiYLGYNNLsgeipYEIGGLTSLNHLDLVY--NNLT 249

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755516220 232 ETLNGFSQEMKSLQYLNLRSNMISDLAElAKLRDLPKLRALVLLDNPCADETdyrQEALVQMAHLERL 299
Cdd:PLN00113 250 GPIPSSLGNLKNLQYLFLYQNKLSGPIP-PSIFSLQKLISLDLSDNSLSGEI---PELVIQLQNLEIL 313
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-160 5.31e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  90 LRYVDISENHITDISPLNSLTHLLWLKADGNQLRSAR-----MNELPYLQIASFSYN----------QIIdtegIFHPRL 154
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNpvckkpkyrdKII----LASKSL 197


                 ....*.
gi 755516220 155 GSLDLK 160
Cdd:cd21340  198 EVLDGK 203
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 157-301 6.51e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 6.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 157 LDLKGNRIHQVTGLdpERLSSLHTLELRGNQLESTKGI-YLPKLKNLYLAQNLLKKVEGLENLSNLTTLHL--------- 226
Cdd:cd21340   29 LYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlppge 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 227 ---------------------RDNQIETLNGFSqEMKSLQYLNLRSNMISDLAELAK-LRDLPKLRALVLLDNPCADETD 284
Cdd:cd21340  107 kltfdprslaalsnslrvlniSGNNIDSLEPLA-PLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPK 185

                        170
                 ....*....|....*..
gi 755516220 285 YRQEALVQMAHLERLDK 301
Cdd:cd21340  186 YRDKIILASKSLEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-285 2.85e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  78 LTDI-SLLRSYIHLRYVDISENHITDI-SPLNSLTHLLWLKADGNQLRS--ARMNELPYLQIASFSYNQIIDTEGIFH-- 151
Cdd:COG4886  125 LTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlpEELGNLTNLKELDLSNNQITDLPEPLGnl 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 152 PRLGSLDLKGNRIhqvTGLDPE--RLSSLHTLELRGNQLESTKGI-YLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRD 228
Cdd:COG4886  205 TNLEELDLSGNQL---TDLPEPlaNLTNLETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSN 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755516220 229 NQIETLNGFSQEMKSLQYLNLRSNMISDLAELAKLRDLPKLRALVLLDNPCADETDY 285
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-277 1.24e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  95 ISENHITDISPLNSLTHLLWLKADGNQLrsarMNELPYLQIASFSYNQIIDTEGIFH--PRLGSLDLKGNRIhqvTGLDP 172
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEE----LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQL---TDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 173 E--RLSSLHTLELRGNQLES-TKGI-YLPKLKNLYLAQNLLKKV-EGLENLSNLTTLHLRDNQIETLNGFSQEMKSLQYL 247
Cdd:COG4886  154 PlgNLTNLKSLDLSNNQLTDlPEELgNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETL 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 755516220 248 NLRSNMISDLAELAKlrdLPKLRALVLLDN 277
Cdd:COG4886  234 DLSNNQLTDLPELGN---LTNLEELDLSNN 260
LRR_9 pfam14580
Leucine-rich repeat;
181-314 1.22e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  181 LELRGNQLESTK--GIYLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETLN-GFSQEMKSLQYLNLRSNMISDL 257
Cdd:pfam14580  24 LDLRGYKIPIIEnlGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGeGLGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755516220  258 AELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLDKEFYEDDDRAEAEE 314
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-236 1.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  70 KLEAKDRDLTDISL-LRSYIHLRYVDISENHITDIS-PLNSLTHLLWLKADGNQLRS--ARMNELPYLQIASFSYNQIID 145
Cdd:COG4886  163 SLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDlpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 146 TEGIFH-PRLGSLDLKGNRIhqvTGLDPE-RLSSLHTLELRGNQLESTKGIYLPKLKNLYLAQNLLKKVEGLENLSNLTT 223
Cdd:COG4886  243 LPELGNlTNLEELDLSNNQL---TDLPPLaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                        170
                 ....*....|...
gi 755516220 224 LHLRDNQIETLNG 236
Cdd:COG4886  320 LTTLLLLLLLLKG 332
LRR_8 pfam13855
Leucine rich repeat;
197-254 3.17e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.17e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755516220  197 PKLKNLYLAQNLLKKVEG--LENLSNLTTLHLRDNQIETLNGFS-QEMKSLQYLNLRSNMI 254
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 90-299 2.67e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  90 LRYVDISENHITDISplnslthllwLKADGNQLRSARMNELPYLqiasfSYNQIIDTEGIF-------HPRLGSLDLKGN 162
Cdd:COG5238  238 LTTLDLSNNQIGDEG----------VIALAEALKNNTTVETLYL-----SGNQIGAEGAIAlakalqgNTTLTSLDLSVN 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 163 RIHQ--VTGLDP--ERLSSLHTLELRGNQLESTKGIYLpklknlylaqnllkkVEGLENLSNLTTLHLRDNQI-----ET 233
Cdd:COG5238  303 RIGDegAIALAEglQGNKTLHTLNLAYNGIGAQGAIAL---------------AKALQENTTLHSLDLSDNQIgdegaIA 367

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755516220 234 LNGFSQEMKSLQYLNLRSNMISDL--AELAKLRDLPKLRALVLLDNPCADETDYRQEALVQmaHLERL 299
Cdd:COG5238  368 LAKYLEGNTTLRELNLGKNNIGKQgaEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLE--RIKSV 433
LRR_8 pfam13855
Leucine rich repeat;
219-278 3.83e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 3.83e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755516220  219 SNLTTLHLRDNQIETLNGFS-QEMKSLQYLNLRSNMISDLAELAkLRDLPKLRALVLLDNP 278
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-299 5.54e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 5.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  80 DISLLRSyiHLRYVDISENHITDISPLNSLTHLLWLKADGNQLrSARMnelpYLQIASFSynqiidtegifhpRLGSLDL 159
Cdd:PLN00113 112 DIFTTSS--SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNML-SGEI----PNDIGSFS-------------SLKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 160 KGNRIHQVTGLDPERLSSLHTLELRGNQLESTKGIYLPKLKNL---YLAQNLL-----KKVEGLENLSNLTTLHlrDNQI 231
Cdd:PLN00113 172 GGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLkwiYLGYNNLsgeipYEIGGLTSLNHLDLVY--NNLT 249

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755516220 232 ETLNGFSQEMKSLQYLNLRSNMISDLAElAKLRDLPKLRALVLLDNPCADETdyrQEALVQMAHLERL 299
Cdd:PLN00113 250 GPIPSSLGNLKNLQYLFLYQNKLSGPIP-PSIFSLQKLISLDLSDNSLSGEI---PELVIQLQNLEIL 313
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 81-231 1.13e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  81 ISLLRSYIHLRYVDISENHITDISPLNSLTHLlwlkadgnqlrsARMNELPYLQIAsfsYNQIIDTEGIF-------HPR 153
Cdd:COG5238  285 AKALQGNTTLTSLDLSVNRIGDEGAIALAEGL------------QGNKTLHTLNLA---YNGIGAQGAIAlakalqeNTT 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 154 LGSLDLKGNRI--HQVTGL--DPERLSSLHTLELRGNQlestkgiyLPKLKNLYLAQNLLKkveglenlSNLTTLHLRDN 229
Cdd:COG5238  350 LHSLDLSDNQIgdEGAIALakYLEGNTTLRELNLGKNN--------IGKQGAEALIDALQT--------NRLHTLILDGN 413


                 ..
gi 755516220 230 QI 231
Cdd:COG5238  414 LI 415
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 197-239 4.18e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 4.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755516220  197 PKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDN-QIETLNGFSQ 239
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 220-262 2.48e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755516220  220 NLTTLHLRDNQIETLNGFSQeMKSLQYLNLRSN-MISDLAELAK 262
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAK-LPNLETLDLSGNnKITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 152-282 3.18e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 3.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 152 PRLGSLDLKGNRIHQ------VTGLDPERlsSLHTLELRGNQLESTKGIYLPKLknlylaqnllkkvegLENLSNLTTLH 225
Cdd:COG5238  236 KSLTTLDLSNNQIGDegvialAEALKNNT--TVETLYLSGNQIGAEGAIALAKA---------------LQGNTTLTSLD 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755516220 226 LRDNQI---------ETLngfsQEMKSLQYLNLRSNMISD---LAELAKLRDLPKLRALVLLDNPCADE 282
Cdd:COG5238  299 LSVNRIgdegaialaEGL----QGNKTLHTLNLAYNGIGAqgaIALAKALQENTTLHSLDLSDNQIGDE 363
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 174-282 4.23e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220 174 RLSSLHTLELRGNQLESTKGIYL--------PKLKNLYLAQNLLKkVEGLENLSN-------LTTLHLRDNQ-----IET 233
Cdd:cd00116  106 RSSSLQELKLNNNGLGDRGLRLLakglkdlpPALEKLVLGRNRLE-GASCEALAKalranrdLKELNLANNGigdagIRA 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755516220 234 LNGFSQEMKSLQYLNLRSNMI-----SDLAELakLRDLPKLRALVLLDNPCADE 282
Cdd:cd00116  185 LAEGLKANCNLEVLDLNNNGLtdegaSALAET--LASLKSLEVLNLGDNNLTDA 236
LRR_8 pfam13855
Leucine rich repeat;
176-231 4.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755516220  176 SSLHTLELRGNQLESTKGIY---LPKLKNLYLAQNLLKKVEG--LENLSNLTTLHLRDNQI 231
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-160 5.31e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516220  90 LRYVDISENHITDISPLNSLTHLLWLKADGNQLRSAR-----MNELPYLQIASFSYN----------QIIdtegIFHPRL 154
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNpvckkpkyrdKII----LASKSL 197


                 ....*.
gi 755516220 155 GSLDLK 160
Cdd:cd21340  198 EVLDGK 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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