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    Ptpmeg Protein tyrosine phosphatase Meg [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38059, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptpmegprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase Megprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261985
    Locus tag
    Dmel_CG1228
    See related
    AllianceGenome:FB:FBgn0261985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.211; CG1228; dMEG1; Dmel\CG1228; dptpmeg; dPtpmeg; Meg; MEG1; ptmpeg; PTP-meg; ptpmeg; PTPMEG; scc
    Summary
    Enables non-membrane spanning protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of border follicle cell migration; nervous system development; and thermosensory behavior. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and sensory nervous system primordium. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3) and PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ptpmeg in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (328097..356050)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (328097..356050)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 3 Neighboring gene methuselah-like 9 Neighboring gene methuselah-like 10 Neighboring gene methuselah Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1b Neighboring gene Cell division cycle 5

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    protein tyrosine phosphatase Meg
    Names
    CG1228-PG
    CG1228-PH
    CG1228-PI
    CG1228-PJ
    CG1228-PK
    Meg
    Ptpmeg-PG
    Ptpmeg-PH
    Ptpmeg-PI
    Ptpmeg-PJ
    Ptpmeg-PK
    split central complex
    NP_001163309.2
    NP_001163310.2
    NP_612031.3
    NP_728522.2
    NP_728523.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      328097..356050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167831.3 → NP_728523.2  protein tyrosine phosphatase Meg, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728523.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain
    2. NM_167830.4 → NP_728522.2  protein tyrosine phosphatase Meg, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728522.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain
    3. NM_001169839.3 → NP_001163310.2  protein tyrosine phosphatase Meg, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163310.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain
    4. NM_001169838.3 → NP_001163309.2  protein tyrosine phosphatase Meg, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163309.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain
    5. NM_138187.4 → NP_612031.3  protein tyrosine phosphatase Meg, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612031.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain
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