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    ZNF426 zinc finger protein 426 [ Homo sapiens (human) ]

    Gene ID: 79088, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF426provided by HGNC
    Official Full Name
    zinc finger protein 426provided by HGNC
    Primary source
    HGNC:HGNC:20725
    See related
    Ensembl:ENSG00000130818 AllianceGenome:HGNC:20725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K-RBP
    Summary
    Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in esophagus (RPKM 5.6), ovary (RPKM 2.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF426 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9523223..9538645, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9649415..9664832, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9633899..9649321, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372269 Neighboring gene zinc finger protein 560 Neighboring gene uncharacterized LOC105372268 Neighboring gene actin beta pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9648627-9649362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13931 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:9650343-9651542 Neighboring gene ZNF426 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr19:9677059-9677560 Neighboring gene zinc finger protein 121 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9692318-9693131 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9693132-9693944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9694759-9695570

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC2663

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 426
    Names
    CTC-543D15.7
    KSHV RTA binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300883.3NP_001287812.1  zinc finger protein 426 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB209837, AC008567, BP245135
      Consensus CDS
      CCDS74279.1
      UniProtKB/TrEMBL
      K7ER43
      Related
      ENSP00000468100.1, ENST00000593003.5
      Conserved Domains (6) summary
      smart00349
      Location:460
      KRAB; krueppel associated box
      COG5048
      Location:296448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:186208
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:424449
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001318055.2NP_001304984.1  zinc finger protein 426 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC008567, BC001791, BP245135
      UniProtKB/Swiss-Prot
      Q9BUY5
      Conserved Domains (4) summary
      COG5048
      Location:223375
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:113135
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:351376
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001318056.2NP_001304985.1  zinc finger protein 426 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC008567, BC001791, BE315219, BP245135
      Consensus CDS
      CCDS82285.1
      UniProtKB/TrEMBL
      K7EME3
      Related
      ENSP00000466469.1, ENST00000589289.1
      Conserved Domains (1) summary
      smart00349
      Location:4298
      KRAB; krueppel associated box
    4. NM_024106.3NP_077011.1  zinc finger protein 426 isoform 1

      See identical proteins and their annotated locations for NP_077011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC008567, BC001791, BP245135
      Consensus CDS
      CCDS12215.1
      UniProtKB/Swiss-Prot
      B3KTL2, Q9BUY5
      Related
      ENSP00000253115.1, ENST00000253115.7
      Conserved Domains (5) summary
      smart00349
      Location:4298
      KRAB; krueppel associated box
      COG5048
      Location:334486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:450470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:294319
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9523223..9538645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9649415..9664832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)