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Conserved domains on  [gi|665505934|ref|NP_001287812|]
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zinc finger protein 426 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-60 9.17e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.76  E-value: 9.17e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665505934     4 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEE 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-448 4.34e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 296 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 367
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 368 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 438
Cdd:COG5048  368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 665505934 439 ECKQCGKAFS 448
Cdd:COG5048  448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 2.45e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.45e-05
                          10        20
                  ....*....|....*....|....*.
gi 665505934  256 YLSIHMRTHTGEKPYECKECGKAFNY 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-477 1.64e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 665505934  452 SFQIHERTHTGEKPYECKECGKAFTC 477
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 186-208 6.92e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.92e-04
                          10        20
                  ....*....|....*....|...
gi 665505934  186 FECSHCGKSFINESYLQAHMRTH 208
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-505 3.72e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 665505934  480 SFRIHEKTHTEEKPYKCQQCGKAYSH 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-60 9.17e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.76  E-value: 9.17e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665505934     4 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEE 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.30e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 2.30e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 665505934    3 SVTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 7.93e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 7.93e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 665505934   4 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLA 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-448 4.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 296 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 367
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 368 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 438
Cdd:COG5048  368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 665505934 439 ECKQCGKAFS 448
Cdd:COG5048  448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 7.06e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 7.06e-06
                          10        20
                  ....*....|....*....|....*.
gi 665505934  424 HLKIHMRIHTGEKPYECKQCGKAFSH 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 2.45e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.45e-05
                          10        20
                  ....*....|....*....|....*.
gi 665505934  256 YLSIHMRTHTGEKPYECKECGKAFNY 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-477 1.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 665505934  452 SFQIHERTHTGEKPYECKECGKAFTC 477
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 186-208 6.92e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.92e-04
                          10        20
                  ....*....|....*....|...
gi 665505934  186 FECSHCGKSFINESYLQAHMRTH 208
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 240-323 2.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 240 KPYKCK--ECGKGYRYPAYLSIHMRT-HTGEKPYECKECGKafnySNSFQIHgrthtgEKPYVCKECGKAFTQYSGLSMH 316
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----MNIFSAK------DKPYRCEVCDKRYKNLNGLKYH 417


                 ....*..
gi 665505934 317 vRSHSGD 323
Cdd:COG5189  418 -RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-505 3.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 665505934  480 SFRIHEKTHTEEKPYKCQQCGKAYSH 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-60 9.17e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.76  E-value: 9.17e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665505934     4 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEE 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.30e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 2.30e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 665505934    3 SVTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 7.93e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 7.93e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 665505934   4 VTFDDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLA 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-448 4.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 296 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 367
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 368 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 438
Cdd:COG5048  368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 665505934 439 ECKQCGKAFS 448
Cdd:COG5048  448 LCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-501 1.47e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 110 CEQCGEVFSEHSCLKTHVRTQSTGNTHDCNQYGKDflTLCEKTSTGEKLSEFNQSEKIFSLTPNIVYQR--TSTQEKSFE 187
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCD--KSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 188 CSHCGKSFINESYLQAHMR----THNGEKLYEWRNYG-PGFIdsTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMR 262
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSrdpqLPDLLSISNLRNNPlPGNN--SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 263 THTGEKPYECKECGKAFN-YSNSFQIHGRTHTgEKPYVCKECGKAFTQYSGLSMHVRSHSGDKPYECKECGKSFLTSSRL 341
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYsIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 342 IQHIRTHTGE-------KPFVCVECGKAFAVSSNLSGHLRT--HTEEKA----CECKICGKVFGYPSCLNNHMRTHSAQK 408
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpfsCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 409 PYTCKEC------GKAFNYSTHLKIHMR-IHTGEKPYEC--KQCGKAFSHSSSFQIHERTHTGEKPYECK--ECGKAFTC 477
Cdd:COG5048  351 PAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 665505934 478 SSSFRIHEKTHTEEKPYKCQQCGK 501
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 7.06e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 7.06e-06
                          10        20
                  ....*....|....*....|....*.
gi 665505934  424 HLKIHMRIHTGEKPYECKQCGKAFSH 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-516 1.12e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 225 DSTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMRTHTGEKPYECKECGKAFNYSN--SFQIHGRTHTGEKPYVCKE 302
Cdd:COG5048   17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 303 CGKAFTQYSGLSMHVRSHSGDkPYECKECGKSFLTSSRLIQHI----RTHTGEKPF---------------------VCV 357
Cdd:COG5048   97 SLPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLpgnnsssvntpqsnslhpplpANS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 358 ECGKAFAVSSNLSGHLRTHTEEKACECKICGKVFGYPSCLNNHMRTHS-----AQKPYTCKECGKAFNYSTHLKIHMRIH 432
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSssslpLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 433 TGEKPYECKQCGKAFSHSSSFQIHERTHTG-EKPYECKECGKAFTCSSSFRIHEKT--HTEE--KPYKC--QQCGKAYSH 505
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                        330
                 ....*....|.
gi 665505934 506 PRSLRRHEQIH 516
Cdd:COG5048  336 NDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 2.45e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.45e-05
                          10        20
                  ....*....|....*....|....*.
gi 665505934  256 YLSIHMRTHTGEKPYECKECGKAFNY 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-477 1.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 665505934  452 SFQIHERTHTGEKPYECKECGKAFTC 477
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-421 4.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.09e-04
                          10        20
                  ....*....|....*....|....*
gi 665505934  397 LNNHMRTHSAQKPYTCKECGKAFNY 421
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 186-208 6.92e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.92e-04
                          10        20
                  ....*....|....*....|...
gi 665505934  186 FECSHCGKSFINESYLQAHMRTH 208
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-337 7.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.29e-04
                          10        20
                  ....*....|....*....|....*
gi 665505934  313 LSMHVRSHSGDKPYECKECGKSFLT 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 240-323 2.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 240 KPYKCK--ECGKGYRYPAYLSIHMRT-HTGEKPYECKECGKafnySNSFQIHgrthtgEKPYVCKECGKAFTQYSGLSMH 316
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----MNIFSAK------DKPYRCEVCDKRYKNLNGLKYH 417


                 ....*..
gi 665505934 317 vRSHSGD 323
Cdd:COG5189  418 -RKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 410-432 2.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|...
gi 665505934  410 YTCKECGKAFNYSTHLKIHMRIH 432
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-483 2.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 180 STQEKSFECSHCGKSFINESYLQAHMRTHNGEKLYEWRNYG--PGFIDSTSLSVLIETLNAKKPYKC-KECGKGYRYPAY 256
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 257 LSIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHT---GEKPYVCKECGKAFTQYSGLSMHVRSHSGDKPyecKECGK 333
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 334 SFLTSSRLIQHIRTHT----------------------GEKPFVCVECGKAFAVSSNLSGHLRTHTEEKACECKICG--- 388
Cdd:COG5048  185 SLLISSNVSTSIPSSSensplsssysipssssdqnlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrss 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505934 389 ---KVFGYPSCLNNHMRTHSAQ-KPYTCKECGKAFNYSTHLKIHMR--IHTGE--KPYEC--KQCGKAFSHSSSFQIHER 458
Cdd:COG5048  265 lptASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340
                 ....*....|....*....|....*
gi 665505934 459 THTGEKPYECKECgkafTCSSSFRI 483
Cdd:COG5048  345 LHTSISPAKEKLL----NSSSKFSP 365
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-505 3.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 665505934  480 SFRIHEKTHTEEKPYKCQQCGKAYSH 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-364 3.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|....*
gi 665505934  340 RLIQHIRTHTGEKPFVCVECGKAFA 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 5.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 665505934  284 SFQIHGRTHTGEKPYVCKECGKAFTQ 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 438-460 8.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.21e-03
                          10        20
                  ....*....|....*....|...
gi 665505934  438 YECKQCGKAFSHSSSFQIHERTH 460
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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