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EFM3 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853593, updated on 4-Jan-2025

Summary

Official Symbol
EFM3
Official Full Name
protein-lysine N-methyltransferase
Primary source
SGD:S000003890
Locus tag
YJR129C
See related
AllianceGenome:SGD:S000003890; FungiDB:YJR129C; VEuPathDB:YJR129C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Orthologous to several human genes including EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See EFM3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (664000..665019, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Rsf2p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cystathionine gamma-synthase Neighboring gene mannosyl-oligosaccharide 1,2-alpha-mannosidase

Bibliography

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytoplasm  

General protein information

Preferred Names
protein-lysine N-methyltransferase
NP_012663.2
  • S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    664000..665019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181787.2 → NP_012663.2  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012663.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWU7, P47163
    UniProtKB/TrEMBL
    A6ZQ84, B3LQL1, N1P0A5
    Conserved Domains (1) summary
    cl17173
    Location:137 → 286
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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