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CMK1 calmodulin-dependent protein kinase CMK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850568, updated on 4-Jan-2025

Summary

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Official Symbol
CMK1
Official Full Name
calmodulin-dependent protein kinase CMK1
Primary source
SGD:S000001910
Locus tag
YFR014C
See related
AllianceGenome:SGD:S000001910; FungiDB:YFR014C; VEuPathDB:YFR014C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables calcium/calmodulin-dependent protein kinase activity. Involved in signal transduction. Located in cytoplasm. Human ortholog(s) of this gene implicated in cocaine dependence; glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to several human genes including CAMKV (CaM kinase like vesicle associated); CAMK1G (calcium/calmodulin dependent protein kinase IG); and PNCK (pregnancy up-regulated nonubiquitous CaM kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CMK1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (172537..173877, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ioc3p Neighboring gene glycogen (starch) synthase GSY1 Neighboring gene Aip5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote. Pausch MH, et al. EMBO J, 1991 Jun. PMID 2026147, Free PMC Article
  2. Two yeast genes encoding calmodulin-dependent protein kinases. Isolation, sequencing and bacterial expressions of CMK1 and CMK2. Ohya Y, et al. J Biol Chem, 1991 Jul 5. PMID 2061341
  3. Specific conformation and Ca(2+)-binding mode of yeast calmodulin: insight into evolutionary development. Nakashima K, et al. J Biochem, 2012 Jul. PMID 22563102
  4. The diverse role of Pdr12 in resistance to weak organic acids. Nygård Y, et al. Yeast, 2014 Jun. PMID 24691985
  5. Loss of Cmk1 Ca(2+)-calmodulin-dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post-transcriptional activation of the Pdr12 ATP-binding cassette transporter. Holyoak CD, et al. Mol Microbiol, 2000 Aug. PMID 10931353

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calmodulin-dependent protein kinase CMK1
NP_116669.1
  • Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    172537..173877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179979.2 → NP_116669.1  TPA: calmodulin-dependent protein kinase CMK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTP5, P27466
    UniProtKB/TrEMBL
    A7A252, G2WDF3
    Conserved Domains (1) summary
    cd05117
    Location:36 → 298
    STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27466.2

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