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WRR4 Disease resistance protein (TIR-NBS-LRR class) [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842104, updated on 18-Sep-2024

Summary

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Official Symbol
WRR4
Official Full Name
Disease resistance protein (TIR-NBS-LRR class)
Primary source
TAIR:AT1G56510
Locus tag
AT1G56510
See related
Araport:AT1G56510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACTIVATED DISEASE RESISTANCE 2; ADR2; F13N6.5; F13N6_5; WHITE RUST RESISTANCE 4
Summary
TIR-NB-LRR protein that confers resistance to four races of Albugo candida.
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Genomic context

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See WRR4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (21167565..21173632)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene haloacid dehalogenase-like hydrolase family protein Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene hydroxyproline-rich glycoprotein family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities. Castel B, et al. Plant J, 2021 Sep. PMID 34181787
  2. Arabidopsis thaliana natural variation reveals connections between UV radiation stress and plant pathogen-like defense responses. Piofczyk T, et al. Plant Physiol Biochem, 2015 Aug. PMID 25656510
  3. WRR4, a broad-spectrum TIR-NB-LRR gene from Arabidopsis thaliana that confers white rust resistance in transgenic oilseed Brassica crops. Borhan MH, et al. Mol Plant Pathol, 2010 Mar. PMID 20447277, Free PMC Article
  4. Activation tagging of ADR2 conveys a spreading lesion phenotype and resistance to biotrophic pathogens. Aboul-Soud MAM, et al. New Phytol, 2009. PMID 19549129
  5. WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis thaliana to four physiological races of Albugo candida. Borhan MH, et al. Mol Plant Microbe Interact, 2008 Jun. PMID 18624640

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities.
    Title: Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities.
  2. adr2-mediated resistance operates through an Enhanced Disease Susceptibility (EDS) and SA-dependent defence signalling network which functions independently from COI1 or ETR1. [activated disease resistance 2] [ADR2]
    Title: Activation tagging of ADR2 conveys a spreading lesion phenotype and resistance to biotrophic pathogens.
  3. WRR4 could potentially provide a novel source of white rust resistance in oilseed and vegetable brassica crops.
    Title: WRR4, a broad-spectrum TIR-NB-LRR gene from Arabidopsis thaliana that confers white rust resistance in transgenic oilseed Brassica crops.
  4. WRR4 (At1g56510 )encodes a cytoplasmic toll-interleukin receptor-like nucleotide-binding leucine-rich repeat receptor-like protein that confers a dominant, broad-spectrum white rust resistance(WRR
    Title: WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis thaliana to four physiological races of Albugo candida.
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General gene information

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NM_104527.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to oomycetes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Disease resistance protein (TIR-NBS-LRR class)
NP_176043.1
  • WHITE RUST RESISTANCE 4 (WRR4); FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: defense response to fungus, incompatible interaction, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT1G56540.1); Has 19205 Blast hits to 15135 proteins in 571 species: Archae - 14; Bacteria - 975; Metazoa - 1259; Fungi - 71; Plants - 16420; Viruses - 8; Other Eukaryotes - 458 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    21167565..21173632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104527.4 → NP_176043.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176043.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9C7X0
    UniProtKB/TrEMBL
    A0A5S9WQ84, A0A654EP54
    Conserved Domains (6) summary
    PLN03210
    Location:1 → 997
    PLN03210; Resistant to P. syringae 6; Provisional
    sd00033
    Location:603 → 621
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:626 → 648
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam01582
    Location:13 → 176
    TIR; TIR domain
    pfam07725
    Location:602 → 621
    LRR_3; Leucine Rich Repeat
    pfam13191
    Location:187 → 310
    AAA_16; AAA ATPase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C7X0.1

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