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FLP Duplicated homeodomain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837997, updated on 18-Sep-2024

Summary

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Official Symbol
FLP
Official Full Name
Duplicated homeodomain-like superfamily protein
Primary source
TAIR:AT1G14350
Locus tag
AT1G14350
See related
Araport:AT1G14350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtMYB124; F14L17.12; F14L17_12; FOUR LIPS; myb domain protein 124; MYB124
Summary
Encodes a putative MYB transcription factor involved in stomata development, loss of FLP activity results in a failure of guard mother cells (GMCs) to adopt the guard cell fate, thus they continue to divide resulting in abnormal stomata consisting of clusters of numerous guard cell-like cells. This phenotype is enhanced in double mutants with MYB88. Its transcript levels change after inducing MUTE expression in a mute background.
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Genomic context

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See FLP in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (4907887..4911168)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UDP-galactose transporter 3 Neighboring gene ncRNA Neighboring gene protein kinase 2A Neighboring gene IQ-domain 28 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis. Li P, et al. Plant J, 2023 Apr. PMID 36786686
  2. Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes. Lee E, et al. Plant J, 2014 May. PMID 24654956
  3. Divergent regulation of stomatal initiation and patterning in organ and suborgan regions of the Arabidopsis mutants too many mouths and four lips. Geisler M, et al. Planta, 1998 Aug. PMID 9684356
  4. The Arabidopsis R2R3 MYB proteins FOUR LIPS and MYB88 restrict divisions late in the stomatal cell lineage. Lai LB, et al. Plant Cell, 2005 Oct. PMID 16155180, Free PMC Article
  5. Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses. Xie Z, et al. Plant J, 2010 Dec. PMID 21105921

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis.
    Title: FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis.
  2. FLP and MYB88 inhibit the production of nonstomatal epidermal cells largely in a growth-condition-dependent manner.
    Title: The FOUR LIPS (FLP) and MYB88 genes conditionally suppress the production of nonstomatal epidermal cells in Arabidopsis cotyledons.
  3. Both flp and myb88 genes were expressed in many, previously unreported locations, consistent with the possibility of additional functions for FLP and MYB88. Moreover, expression domains especially of FLP display sharp cutoffs or boundaries.
    Title: The FOUR LIPS and MYB88 transcription factor genes are widely expressed in Arabidopsis thaliana during development.
  4. FLP and MYB88 expression specifically determines the temporal-spatial patterns of PIN3 and PIN7 transcription that are closely associated with their preferential functions during root responses to gravity.
    Title: Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism.
  5. ARF7 and FLP transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation.
    Title: A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development.
  6. Data indicate that MYB transcription factor FOUR LIPS (FLP) and bHLH transcription factor FAMA complement respective mutant phenotypes.
    Title: Deep functional redundancy between FAMA and FOUR LIPS in stomatal development.
  7. Data indicate that bHLH transcription factor FAMA and MYB transcription factor FOUR LIPS (FLP) genes stabilize guard cell fate.
    Title: Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes.
  8. FLP and MYB88 restrict the G1/S transition during stomatal formation.
    Title: FOUR LIPS and MYB88 conditionally restrict the G1/S transition during stomatal formation.
  9. FLP and MYB88 are important regulators of entry into megasporogenesis, and probably act via the regulation of cell cycle genes.
    Title: The R2R3 MYB transcription factors FOUR LIPS and MYB88 regulate female reproductive development.
  10. flp-1 myb88 double mutant plants show enhanced sensitivity to drought and salt stress.
    Title: Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses.
Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Homology

NM_001084065.3
NM_001332112.1
NM_001332113.1
NM_101302.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in auxin polar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo sac development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within guard cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in guard cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within guard cell differentiation NAS
Non-traceable Author Statement
more info
  
involved_in guard mother cell cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in guard mother cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leaf pavement cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megasporogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organismal-level water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lateral root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stomatal complex patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to auxin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to gravity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stomatal complex formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stomatal complex formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Duplicated homeodomain-like superfamily protein
NP_001077534.1
  • FOUR LIPS (FLP); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 88 (TAIR:AT2G02820.2); Has 8538 Blast hits to 7627 proteins in 543 species: Archae - 0; Bacteria - 2; Metazoa - 904; Fungi - 528; Plants - 5146; Viruses - 6; Other Eukaryotes - 1952 (source: NCBI BLink).
NP_563948.1
  • FOUR LIPS (FLP); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 88 (TAIR:AT2G02820.2); Has 8541 Blast hits to 7630 proteins in 544 species: Archae - 0; Bacteria - 2; Metazoa - 904; Fungi - 531; Plants - 5146; Viruses - 6; Other Eukaryotes - 1952 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4907887..4911168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001084065.3 → NP_001077534.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077534.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94FL6, Q9M9S7
    UniProtKB/TrEMBL
    A0A178W3Z3, A0A5S9UE35, A0A654E9M7
    Conserved Domains (1) summary
    PLN03091
    Location:28 → 223
    PLN03091; hypothetical protein; Provisional

  2. NM_001332112.1 → NP_001321792.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AS18, A0A654E9M7

  3. NM_101302.3 → NP_563948.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563948.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94FL6, Q9M9S7
    UniProtKB/TrEMBL
    A0A178W3Z3, A0A5S9UE35, A0A654E9M7
    Conserved Domains (1) summary
    PLN03091
    Location:28 → 223
    PLN03091; hypothetical protein; Provisional

  4. NM_001332113.1 → NP_001321793.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AS18, A0A654E9M7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94FL6.1

Gene LinkOut

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