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TTR1 Disease resistance protein (TIR-NBS-LRR class) [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834536, updated on 18-Sep-2024

Summary

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Official Symbol
TTR1
Official Full Name
Disease resistance protein (TIR-NBS-LRR class)
Primary source
TAIR:AT5G45050
Locus tag
AT5G45050
See related
Araport:AT5G45050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATWRKY16; K21C13.24; K21C13_24; TOLERANT TO TOBACCO RINGSPOT NEPOVIRUS 1; WRKY16
Summary
Encodes a member of the WRKY Transcription Factor (Group II-e) family.
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Genomic context

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See TTR1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Sequence:
Chromosome: 5; NC_003076.8 (18176894..18181973, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DSS1 homolog on chromosome V Neighboring gene Glutathione S-transferase family protein Neighboring gene ncRNA Neighboring gene Trypsin family protein Neighboring gene Cytochrome c Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene phloem protein 2-A8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4. Saucet SB, et al. Nat Commun, 2015 Mar 6. PMID 25744164
  2. The WRKY superfamily of plant transcription factors. Eulgem T, et al. Trends Plant Sci, 2000 May. PMID 10785665
  3. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
  4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
  5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An R gene pair that resembles and is linked to RRS1/RPS4, designated as RRS1B/RPS4B, confers recognition of AvrRps4 from Pseudomonas syringae. [RRS1B]
    Title: Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001344582.1
NM_001344583.1
NM_123873.3
NM_180802.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response-activating signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plant-type vacuole HDA PubMed 

General protein information

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Preferred Names
Disease resistance protein (TIR-NBS-LRR class)
NP_199318.2
  • TOLERANT TO TOBACCO RINGSPOT NEPOVIRUS 1 (TTR1); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to virus, plant-type hypersensitive response; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G45260.1); Has 18972 Blast hits to 14972 proteins in 610 species: Archae - 6; Bacteria - 638; Metazoa - 199; Fungi - 9; Plants - 17764; Viruses - 2; Other Eukaryotes - 354 (source: NCBI BLink).
NP_851133.1
  • TOLERANT TO TOBACCO RINGSPOT NEPOVIRUS 1 (TTR1); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to virus, plant-type hypersensitive response; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G45260.1); Has 19463 Blast hits to 15000 proteins in 640 species: Archae - 10; Bacteria - 753; Metazoa - 207; Fungi - 5; Plants - 18197; Viruses - 4; Other Eukaryotes - 287 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18176894..18181973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123873.3 → NP_199318.2  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199318.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UNI2, F4KBS5
    Conserved Domains (7) summary
    smart00774
    Location:1153 → 1209
    WRKY; DNA binding domain
    PLN03210
    Location:14 → 1022
    PLN03210; Resistant to P. syringae 6; Provisional
    sd00033
    Location:571 → 593
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:594 → 616
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam01582
    Location:7 → 137
    TIR; TIR domain
    pfam07725
    Location:570 → 589
    LRR_3; Leucine Rich Repeat
    pfam13191
    Location:164 → 274
    AAA_16; AAA ATPase domain

  2. NM_001344582.1 → NP_001332492.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UNI2, A0A1P8BH45

  3. NM_180802.2 → NP_851133.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851133.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FL92
    UniProtKB/TrEMBL
    A0A178UNI2
    Conserved Domains (6) summary
    smart00774
    Location:1181 → 1237
    WRKY; DNA binding domain
    PLN03210
    Location:14 → 1050
    PLN03210; Resistant to P. syringae 6; Provisional
    sd00034
    Location:594 → 616
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam01582
    Location:7 → 137
    TIR; TIR domain
    pfam07725
    Location:570 → 589
    LRR_3; Leucine Rich Repeat
    pfam13191
    Location:164 → 274
    AAA_16; AAA ATPase domain

  4. NM_001344583.1 → NP_001332491.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UNI2, A0A1P8BH86
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FL92.1

Gene LinkOut

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