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FSD1 Fe superoxide dismutase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828613, updated on 18-Sep-2024

Summary

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Official Symbol
FSD1
Official Full Name
Fe superoxide dismutase 1
Primary source
TAIR:AT4G25100
Locus tag
AT4G25100
See related
Araport:AT4G25100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS FE SUPEROXIDE DISMUTASE 1; ATFSD1; F24A6.1; Fe superoxide dismutase 1
Summary
Fe-superoxide dismutase
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Genomic context

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See FSD1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Sequence:
Chromosome: 4; NC_003075.7 (12884300..12887011, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene caldesmon-like protein Neighboring gene magnesium-protoporphyrin IX methyltransferase Neighboring gene Riboflavin synthase-like superfamily protein Neighboring gene metacaspase 2 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo light-sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection. Dvořák P, et al. Plant Cell Environ, 2021 Jan. PMID 32974958
  2. Characterization of iron superoxide dismutase cDNAs from plants obtained by genetic complementation in Escherichia coli. Van Camp W, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2263641, Free PMC Article
  3. Study of oxidative stress related responses induced in Arabidopsis thaliana following mixed exposure to uranium and cadmium. Vanhoudt N, et al. Plant Physiol Biochem, 2010 Oct-Nov. PMID 20822913
  4. Comparison of global responses to mild deficiency and excess copper levels in Arabidopsis seedlings. Andrés-Colás N, et al. Metallomics, 2013 Sep. PMID 23455955
  5. CHAPERONIN 20 mediates iron superoxide dismutase (FeSOD) activity independent of its co-chaperonin role in Arabidopsis chloroplasts. Kuo WY, et al. New Phytol, 2013 Jan. PMID 23057508

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo light-sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection.
    Title: In vivo light-sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection.
  2. The expression of SPL7 and its targets COPT2 and FSD1 was differently regulated in various light signalling mutants. Under copper deficiency, the expression of both targets decreased drastically in continuous darkness.
    Title: Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana.
  3. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6, was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
    Title: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.
  4. Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2, miRNA398 b/c precursors and FSD1.
    Title: The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana.
  5. Data suggest that iron superoxide dismutase gene FSD1 and SPL7 transcriptional regulator SPL7 may associate withi copper homeostasis.
    Title: Comparison of global responses to mild deficiency and excess copper levels in Arabidopsis seedlings.
  6. CPN20 silencing decreases iron superoxide dismutases activity in chloroplast.
    Title: CHAPERONIN 20 mediates iron superoxide dismutase (FeSOD) activity independent of its co-chaperonin role in Arabidopsis chloroplasts.
  7. While for roots, based on an increase in FSD1 gene expression, oxidative stress was suggested to be superoxide induced...
    Title: Study of oxidative stress related responses induced in Arabidopsis thaliana following mixed exposure to uranium and cadmium.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036633.2
NM_001203905.1
NM_118642.2
NM_179109.3
NM_179110.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion binding HDA PubMed 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within removal of superoxide radicals IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to copper ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to light intensity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ozone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in thylakoid HDA PubMed 

General protein information

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Preferred Names
Fe superoxide dismutase 1
NP_001031710.1
  • Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: mitochondrion, chloroplast, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001190834.1
  • Fe superoxide dismutase 1 (FSD1); CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1).
NP_194240.1
  • Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 11570 Blast hits to 11569 proteins in 3359 species: Archae - 194; Bacteria - 8166; Metazoa - 431; Fungi - 784; Plants - 398; Viruses - 1; Other Eukaryotes - 1596 (source: NCBI BLink).
NP_849440.1
  • Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: thylakoid, mitochondrion, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 11570 Blast hits to 11569 proteins in 3359 species: Archae - 194; Bacteria - 8166; Metazoa - 431; Fungi - 784; Plants - 398; Viruses - 1; Other Eukaryotes - 1596 (source: NCBI BLink).
NP_849441.1
  • Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: thylakoid, mitochondrion, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 11570 Blast hits to 11569 proteins in 3359 species: Archae - 194; Bacteria - 8166; Metazoa - 431; Fungi - 784; Plants - 398; Viruses - 1; Other Eukaryotes - 1596 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12884300..12887011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179109.3 → NP_849440.1  Fe superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21276, Q9FE21, Q9SW16
    UniProtKB/TrEMBL
    A0A5S9XVM4, A0A654FSM5
    Conserved Domains (1) summary
    PLN02184
    Location:1 → 212
    PLN02184; superoxide dismutase [Fe]

  2. NM_001036633.2 → NP_001031710.1  Fe superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031710.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JRV2
    Conserved Domains (3) summary
    COG0605
    Location:1 → 184
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
    pfam00081
    Location:1 → 68
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:79 → 177
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

  3. NM_179110.2 → NP_849441.1  Fe superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849441.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21276, Q9FE21, Q9SW16
    UniProtKB/TrEMBL
    A0A5S9XVM4, A0A654FSM5
    Conserved Domains (1) summary
    PLN02184
    Location:1 → 212
    PLN02184; superoxide dismutase [Fe]

  4. NM_118642.2 → NP_194240.1  Fe superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21276, Q9FE21, Q9SW16
    UniProtKB/TrEMBL
    A0A5S9XVM4, A0A654FSM5
    Conserved Domains (1) summary
    PLN02184
    Location:1 → 212
    PLN02184; superoxide dismutase [Fe]

  5. NM_001203905.1 → NP_001190834.1  Fe superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21276, Q9FE21, Q9SW16
    UniProtKB/TrEMBL
    A0A5S9XVM4, A0A654FSM5
    Conserved Domains (1) summary
    PLN02184
    Location:1 → 212
    PLN02184; superoxide dismutase [Fe]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21276.4

Gene LinkOut

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