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IMPA-2 importin alpha isoform 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827302, updated on 18-Sep-2024

Summary

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Official Symbol
IMPA-2
Official Full Name
importin alpha isoform 2
Primary source
TAIR:AT4G16143
Locus tag
AT4G16143
See related
Araport:AT4G16143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
importin alpha isoform 2
Summary
Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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Genomic context

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See IMPA-2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (9133750..9137415, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene proline-rich family protein Neighboring gene GATA type zinc finger transcription factor family protein Neighboring gene associated molecule with the SH3 domain of STAM 3 Neighboring gene cAMP-regulated phosphoprotein 19-related protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWO1 modulates cell wall integrity under salt stress by interacting with importin ɑ in Arabidopsis. Wang Z, et al. Stress Biol, 2021 Sep 29. PMID 37676567, Free PMC Article
  2. The intrinsically disordered N-terminal region of AtREM1.3 remorin protein mediates protein-protein interactions. Marín M, et al. J Biol Chem, 2012 Nov 16. PMID 23027878, Free PMC Article
  3. An Arabidopsis homolog of importin β1 is required for ABA response and drought tolerance. Luo Y, et al. Plant J, 2013 Aug. PMID 23582042
  4. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Boudolf V, et al. Plant Physiol, 2009 Jul. PMID 19458112, Free PMC Article
  5. A tandem affinity purification-based technology platform to study the cell cycle interactome in Arabidopsis thaliana. Van Leene J, et al. Mol Cell Proteomics, 2007 Jul. PMID 17426018

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001160767.2
NM_117708.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in nucleolus HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
importin alpha isoform 2
NP_001154239.1
  • importin alpha isoform 2 (IMPA-2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4654 Blast hits to 3364 proteins in 293 species: Archae - 4; Bacteria - 33; Metazoa - 1869; Fungi - 640; Plants - 1336; Viruses - 0; Other Eukaryotes - 772 (source: NCBI BLink).
NP_567485.4
  • importin alpha isoform 2 (IMPA-2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol, nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4654 Blast hits to 3364 proteins in 293 species: Archae - 4; Bacteria - 33; Metazoa - 1869; Fungi - 640; Plants - 1336; Viruses - 0; Other Eukaryotes - 772 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9133750..9137415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117708.6 → NP_567485.4  importin alpha isoform 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567485.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JL11, O49600, Q9ASV4
    UniProtKB/TrEMBL
    A0A178V0W7
    Conserved Domains (4) summary
    COG5064
    Location:10 → 535
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:114 → 235
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:8 → 99
    IBB; Importin beta binding domain
    sd00043
    Location:116 → 148
    ARM; armadillo repeat [structural motif]

  2. NM_001160767.2 → NP_001154239.1  importin alpha isoform 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JL11, O49600, Q9ASV4
    UniProtKB/TrEMBL
    A0A178V0W7
    Conserved Domains (4) summary
    COG5064
    Location:10 → 535
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:114 → 235
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:8 → 99
    IBB; Importin beta binding domain
    sd00043
    Location:116 → 148
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4JL11.1

Gene LinkOut

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