PLDGAMMA1 phospholipase D gamma 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PLDGAMMA1
Official Full Name: phospholipase D gamma 1
Primary source: TAIR:AT4G11850
Locus tag: AT4G11850
See related: Araport:AT4G11850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: maternal effect embryo arrest 54; MEE54; phospholipase D gamma 1
Summary: Encodes a phospholipase D (gamma) that is involved in aluminum tolerance and plays a role in membrane lipid modulation under Al stress.
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Genomic context

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See PLDGAMMA1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (7129123..7133385, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLDgammas play a role in membrane lipid modulation under Al stress and that high activities of PLDgammas negatively modulate plant tolerance to Al
Title: Suppression of phospholipase Dγs confers increased aluminum resistance in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117255.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within membrane lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to aluminum ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase D gamma 1

NP_192922.1

phospholipase D gamma 1 (PLDGAMMA1); FUNCTIONS IN: phospholipase D activity, protein binding, phosphatidylinositol-4,5-bisphosphate binding; INVOLVED IN: defense response to bacterium, incompatible interaction, embryo development ending in seed dormancy; LOCATED IN: plasma membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase D (InterPro:IPR015679), Phospholipase D, plant (InterPro:IPR011402), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: phospholipase D gamma 3 (TAIR:AT4G11840.1); Has 2106 Blast hits to 1666 proteins in 402 species: Archae - 0; Bacteria - 529; Metazoa - 440; Fungi - 441; Plants - 536; Viruses - 0; Other Eukaryotes - 160 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7129123..7133385 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117255.3 → NP_192922.1 phospholipase D gamma 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48544, Q9T053

UniProtKB/TrEMBL

A0A5S9XS83

Conserved Domains (4) summary

cd04015
Location:39 → 186

C2_plant_PLD; C2 domain present in plant phospholipase D (PLD)

PLN03008
Location:37 → 857

PLN03008; Phospholipase D delta

pfam12357
Location:781 → 849

PLD_C; Phospholipase D C terminal

cl15239
Location:537 → 754

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins