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OASC O-acetylserine (thiol) lyase isoform C [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825145, updated on 18-Sep-2024

Summary

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Official Symbol
OASC
Official Full Name
O-acetylserine (thiol) lyase isoform C
Primary source
TAIR:AT3G59760
Locus tag
AT3G59760
See related
Araport:AT3G59760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA CYSTEINSYNTHASE-C; ATCS-C; CSASE C; O-acetylserine (thiol) lyase isoform C
Summary
Arabidopsis thaliana O-acetylserine (thiol) lyase (OAS-TL) isoform oasC. Required for pollen tube growth and/or fertilization.
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Genomic context

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See OASC in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (22071948..22075453, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene ncRNA Neighboring gene sacI homology domain-containing protein / WW domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial sulfide detoxification requires a functional isoform O-acetylserine(thiol)lyase C in Arabidopsis thaliana. Álvarez C, et al. Mol Plant, 2012 Nov. PMID 22511607
  2. The cysteine synthase complex from plants. Mitochondrial serine acetyltransferase from Arabidopsis thaliana carries a bifunctional domain for catalysis and protein-protein interaction. Wirtz M, et al. Eur J Biochem, 2001 Feb. PMID 11168407
  3. Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana. Feldman-Salit A, et al. Structure, 2012 Feb 8. PMID 22325778
  4. Use of biomolecular interaction analysis to elucidate the regulatory mechanism of the cysteine synthase complex from Arabidopsis thaliana. Berkowitz O, et al. J Biol Chem, 2002 Aug 23. PMID 12063244
  5. Successful fertilization requires the presence of at least one major O-acetylserine(thiol)lyase for cysteine synthesis in pollen of Arabidopsis. Birke H, et al. Plant Physiol, 2013 Oct. PMID 24001608, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the significance of OAS-C is related to its role in the proper sulfide and cyanide detoxification in mitochondria
    Title: Mitochondrial sulfide detoxification requires a functional isoform O-acetylserine(thiol)lyase C in Arabidopsis thaliana.
  2. We describe the crystal structure of OAS-TLC from A. thaliana mitochondria and compare it with our previously modeled structure.
    Title: Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana.
  3. Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
    Title: Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_115838.6
NM_180691.1
NM_180692.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables cysteine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cysteine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within double fertilization forming a zygote and endosperm IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pollen tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen tube growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
O-acetylserine (thiol) lyase isoform C
NP_191535.2
  • O-acetylserine (thiol) lyase isoform C (OASC); FUNCTIONS IN: protein binding, cysteine synthase activity, zinc ion binding, ATP binding; INVOLVED IN: cysteine biosynthetic process, pollen tube development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase B (TAIR:AT2G43750.2); Has 22643 Blast hits to 22626 proteins in 2678 species: Archae - 432; Bacteria - 15847; Metazoa - 414; Fungi - 670; Plants - 570; Viruses - 2; Other Eukaryotes - 4708 (source: NCBI BLink).
NP_851022.1
  • O-acetylserine (thiol) lyase isoform C (OASC); FUNCTIONS IN: protein binding, cysteine synthase activity, zinc ion binding, ATP binding; INVOLVED IN: cysteine biosynthetic process, pollen tube development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase B (TAIR:AT2G43750.2); Has 22520 Blast hits to 22503 proteins in 2668 species: Archae - 432; Bacteria - 15729; Metazoa - 413; Fungi - 668; Plants - 568; Viruses - 2; Other Eukaryotes - 4708 (source: NCBI BLink).
NP_851023.1
  • O-acetylserine (thiol) lyase isoform C (OASC); FUNCTIONS IN: protein binding, cysteine synthase activity, zinc ion binding, ATP binding; INVOLVED IN: cysteine biosynthetic process, pollen tube development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase B (TAIR:AT2G43750.2); Has 22651 Blast hits to 22634 proteins in 2657 species: Archae - 442; Bacteria - 15920; Metazoa - 415; Fungi - 665; Plants - 567; Viruses - 2; Other Eukaryotes - 4640 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22071948..22075453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180691.1 → NP_851022.1  O-acetylserine (thiol) lyase isoform C [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V9N8, A0A5S9XMB0, B9DFR6
    Conserved Domains (2) summary
    PLN02565
    Location:113 → 426
    PLN02565; cysteine synthase
    PLN03013
    Location:1 → 429
    PLN03013; cysteine synthase

  2. NM_115838.6 → NP_191535.2  O-acetylserine (thiol) lyase isoform C [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191535.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q43725, Q8L4A2, Q9M1Z8, Q9M440
    UniProtKB/TrEMBL
    A0A178V9N8, A0A5S9XMB0, Q0WWQ5
    Conserved Domains (1) summary
    PLN03013
    Location:1 → 430
    PLN03013; cysteine synthase

  3. NM_180692.1 → NP_851023.1  O-acetylserine (thiol) lyase isoform C [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851023.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V9N8, A0A5S9XMB0, F4J9F7
    Conserved Domains (2) summary
    PLN03013
    Location:1 → 418
    PLN03013; cysteine synthase
    pfam00291
    Location:117 → 379
    PALP; Pyridoxal-phosphate dependent enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q43725.3

Gene LinkOut

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