ATMIN7 HOPM interactor 7 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATMIN7
Official Full Name: HOPM interactor 7
Primary source: TAIR:AT3G43300
Locus tag: AT3G43300
See related: Araport:AT3G43300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BEN1; BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1; HOPM interactor 7; MIN7
Summary: AtMIN7 is an immunity associated Arabidopsis protein targeted by HopM1, a conserved Pseudomonas syringae virulence protein. AtMIN7 encodes one of the eight members of the Arabidopsis adenosine diphosphate (ADP) ribosylation factor (ARF) guanine nucleotide exchange factor (GEF) protein family. The AFR GEF proteins are key components of the vesicle trafficking system in eukaryotic cells. HopM1 mediates the destruction of AtMIN7 via the host proteasome.
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Genomic context

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See ATMIN7 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 33

Sequence:: Chromosome: 3; NC_003074.8 (15233845..15245281, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deciphering the Novel Role of AtMIN7 in Cuticle Formation and Defense against the Bacterial Pathogen Infection.
Title: Deciphering the Novel Role of AtMIN7 in Cuticle Formation and Defense against the Bacterial Pathogen Infection.
BIG5 functions redundantly with BIG3 in plant growth and gravitropism, and BIG5 participates in Brassinosteroid signal transduction pathway through regulating BRI1 trafficking.[BIG5]
Title: Involvement of BIG5 and BIG3 in BRI1 Trafficking Reveals Diverse Functions of BIG-subfamily ARF-GEFs in Plant Growth and Gravitropism.
HLB1 together with MIN7/BEN1 form a complex with actin to modulate the function of the trans-Golgi network (TGN)/early endosome (EE) at the intersection of the exocytic and endocytic pathways in plants.
Title: HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis.
HopM1 enhances the growth of Pseudomonas syringae pv tomato strain DC3000 in salicylic acid-signaling deficient plants. AtMIN7 contributes to Pph-induced PR-1 expression.
Title: The Pseudomonas syringae pv. tomato type III effector HopM1 suppresses Arabidopsis defenses independent of suppressing salicylic acid signaling and of targeting AtMIN7.
BEN1 and BEN2 are collectively required for polar PIN localization, for their dynamic repolarization, and consequently for auxin activity gradient formation and auxin-related developmental processes. [BEN1]
Title: Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana.
AtMIN7 is an immunity-associated protein which is the target for P. syringae virulence protein, HopM1; HopM1 mediates the destruction of AtMIN7 via the host proteasome [AtMIN7]
Title: A bacterial virulence protein suppresses host innate immunity to cause plant disease.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203077.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of root morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: HOPM interactor 7

NP_001190006.1

HOPM interactor 7 (ATMIN7); CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1).

NP_189916.4

HOPM interactor 7 (ATMIN7); FUNCTIONS IN: protein binding, guanyl-nucleotide exchange factor activity; INVOLVED IN: defense response to bacterium, vesicle-mediated transport, growth; LOCATED IN: trans-Golgi network, early endosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

15233845..15245281 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339097.1 → NP_001327198.1 HOPM interactor 7 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IXW1, F4IXW2, Q0WM86, Q9LXK4

UniProtKB/TrEMBL

A0A178V911

Conserved Domains (1) summary

PLN03076
Location:24 → 1739

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
NM_114198.4 → NP_189916.4 HOPM interactor 7 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189916.4

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V911

Conserved Domains (6) summary

PLN03076
Location:24 → 1758

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

pfam01369
Location:599 → 780

Sec7; Sec7 domain

pfam09324
Location:1092 → 1175

DUF1981; Domain of unknown function (DUF1981)

pfam12783
Location:334 → 501

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

pfam16206
Location:1188 → 1341

Mon2_C; C-terminal region of Mon2 protein

pfam16213
Location:102 → 238

DCB; Dimerization and cyclophilin-binding domain of Mon2
NM_001203077.1 → NP_001190006.1 HOPM interactor 7 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190006.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V911

Conserved Domains (6) summary

PLN03076
Location:68 → 1727

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

pfam01369
Location:580 → 761

Sec7; Sec7 domain

pfam09324
Location:1073 → 1156

DUF1981; Domain of unknown function (DUF1981)

pfam12783
Location:334 → 482

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

pfam16206
Location:1220 → 1310

Mon2_C; C-terminal region of Mon2 protein

pfam16213
Location:102 → 238

DCB; Dimerization and cyclophilin-binding domain of Mon2