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RAD54 DNA repair/recombination protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821455, updated on 18-Sep-2024

Summary

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Official Symbol
RAD54
Official Full Name
DNA repair/recombination protein
Primary source
TAIR:AT3G19210
Locus tag
AT3G19210
See related
Araport:AT3G19210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRAD54; CHR25; homolog of RAD54
Summary
Encodes RAD54, a member of the SWI2/SNF2 family of DNA-stimulated ATPases. Functions in DNA repair via homologous recombination.
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Genomic context

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See RAD54 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
21
Sequence:
Chromosome: 3; NC_003074.8 (6652695..6658988, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene autophagy 2 Neighboring gene uncharacterized protein Neighboring gene protein disulfide isomerase Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene tRNA-Arg

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RAD54 forms DNA repair foci in response to DNA damage in living plant cells. Hirakawa T, et al. Plant J, 2017 Apr. PMID 28155243
  2. Homologous recombination in Arabidopsis seeds along the track of energetic carbon ions. Wang T, et al. Mutat Res, 2012 Sep 1. PMID 22683605
  3. RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis. Hernandez Sanchez-Rebato M, et al. PLoS Genet, 2021 May. PMID 34003859, Free PMC Article
  4. LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair. Hirakawa T, et al. Plant Physiol, 2019 Oct. PMID 31366719, Free PMC Article
  5. Isolation and characterization of the RAD54 gene from Arabidopsis thaliana. Osakabe K, et al. Plant J, 2006 Dec. PMID 17227544

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
    Title: SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
  2. RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
    Title: RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
  3. LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair.
    Title: LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair.
  4. The appearance of RAD54 foci was dependent on the ATAXIA-TELANGIECTASIA MUTATED-SUPPRESSOR OF GAMMA RESPONSE 1 pathway, and RAD54 foci were co-localized with gammaH2AX signals. Laser irradiation of a subnuclear area demonstrated that in living cells RAD54 was specifically accumulated at the damaged site. In addition, the formation of RAD54 foci showed specificity for cell type and region. We conclude that RAD54 foci co...
    Title: RAD54 forms DNA repair foci in response to DNA damage in living plant cells.
  5. Study identified a host factor, RAD54, in a screen for replication initiator protein (Rep)-interacting partners and observed its role in DNA replication of the geminivirus mungbean yellow mosaic India virus (MYMIV).
    Title: A novel role for RAD54: this host protein modulates geminiviral DNA replication.
  6. The trans-species compatibility of Rad54 functions, is reported.
    Title: Functional conservation of the yeast and Arabidopsis RAD54-like genes.
  7. findings point to an important role for Rad54 in homologous recombination repair in plants [Rad54]
    Title: Isolation and characterization of the RAD54 gene from Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203004.1
NM_001338387.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological process involved in interaction with host IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in cellular response to gamma radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to metal ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via synthesis-dependent strand annealing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to gamma radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA repair/recombination protein
NP_001189933.1
  • homolog of RAD54 (RAD54); FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; INVOLVED IN: DNA repair, response to gamma radiation, double-strand break repair via homologous recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: style (sensu Poaceae), hydathode, root, petiole; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: switch 2 (TAIR:AT1G03750.1).
NP_188552.3
  • homolog of RAD54 (RAD54); FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; INVOLVED IN: DNA repair, response to gamma radiation, double-strand break repair via homologous recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: style (sensu Poaceae), hydathode, root, petiole, cultured cell; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT1G08600.2); Has 18387 Blast hits to 15591 proteins in 2067 species: Archae - 120; Bacteria - 5826; Metazoa - 3647; Fungi - 4163; Plants - 1557; Viruses - 140; Other Eukaryotes - 2934 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6652695..6658988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112808.4 → NP_188552.3  DNA repair/recombination protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188552.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JB43, Q0PCS3, Q9LJK7
    UniProtKB/TrEMBL
    A0A178VKI0, A0A5S9XDT6, A0A654F8N7
    Conserved Domains (2) summary
    COG0553
    Location:180 → 708
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18004
    Location:180 → 421
    DEXHc_RAD54; DEXH-box helicase domain of RAD54

  2. NM_001203004.1 → NP_001189933.1  DNA repair/recombination protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654F8N7
    Conserved Domains (3) summary
    cd00046
    Location:205 → 353
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:183 → 487
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:531 → 647
    Helicase_C; Helicase conserved C-terminal domain

  3. NM_001338387.1 → NP_001325757.1  DNA repair/recombination protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LM75, A0A654F8N7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0PCS3.1

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