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Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 [ Mus musculus (house mouse) ]

Gene ID: 78754, updated on 27-Nov-2024

Summary

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Official Symbol
Galnt15provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 15provided by MGI
Primary source
MGI:MGI:1926004
See related
Ensembl:ENSMUSG00000021903 AllianceGenome:MGI:1926004
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galntl2; 4631401E18Rik; mpp-GalNAc-T15
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in transport vesicle. Predicted to be active in Golgi apparatus. Is expressed in retina layer; submandibular gland; and submandibular gland primordium. Orthologous to human GALNT15 (polypeptide N-acetylgalactosaminyltransferase 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 11.9), ovary adult (RPKM 10.2) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Galnt15 in Genome Data Viewer
Location:
14 B; 14 19.4 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31750739..31784161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32028782..32062204)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57623 Neighboring gene predicted gene, 53841 Neighboring gene STARR-seq mESC enhancer starr_36333 Neighboring gene diphthamine biosynthesis 3 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene predicted gene, 57612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884
  2. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  3. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  4. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article
  5. MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Kay JN, et al. Nature, 2012 Mar 11. PMID 22407321, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 15
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
galNAc-T-like protein 2
polypeptide GalNAc transferase-like protein 2
polypeptide N-acetylgalactosaminyltransferase-like 2
polypeptide N-acetylgalactosaminyltransferase-like protein 2
pp-GaNTase-like protein 2
protein-UDP acetylgalactosaminyltransferase-like protein 2
NP_084442.1
XP_006519762.1
XP_036014800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030166.3 → NP_084442.1  polypeptide N-acetylgalactosaminyltransferase 15

    See identical proteins and their annotated locations for NP_084442.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133711
    Consensus CDS
    CCDS36859.1
    UniProtKB/Swiss-Prot
    A3KN88, Q9D2N8
    UniProtKB/TrEMBL
    Q60GT1
    Related
    ENSMUSP00000022460.5, ENSMUST00000022460.11
    Conserved Domains (4) summary
    cd02510
    Location:194 → 492
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:506 → 629
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:504 → 627
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191 → 436
    Glyco_tranf_2_3; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31750739..31784161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158907.1 → XP_036014800.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:194 → 359
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_006519699.5 → XP_006519762.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X1

    UniProtKB/TrEMBL
    Q60GT1
    Conserved Domains (2) summary
    cd02510
    Location:194 → 492
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:504 → 641
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RNA

  1. XR_004938460.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2N8.1 GenPept UniProtKB/Swiss-Prot:Q9D2N8

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