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Cyth4 cytohesin 4 [ Mus musculus (house mouse) ]

Gene ID: 72318, updated on 4-Jan-2025

Summary

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Official Symbol
Cyth4provided by MGI
Official Full Name
cytohesin 4provided by MGI
Primary source
MGI:MGI:2441702
See related
Ensembl:ENSMUSG00000018008 AllianceGenome:MGI:2441702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pscd4; mFLJ00017; 2510004M07Rik; 5830469K17Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and intercellular bridge. Is expressed in brain. Orthologous to human CYTH4 (cytohesin 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in spleen adult (RPKM 42.0), mammary gland adult (RPKM 21.8) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Cyth4 in Genome Data Viewer
Location:
15 E1; 15 37.59 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78481247..78506219)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78597047..78622019)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78394443-78394712 Neighboring gene Rac family small GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78402050-78402237 Neighboring gene STARR-positive B cell enhancer ABC_E11809 Neighboring gene predicted gene, 36738 Neighboring gene STARR-positive B cell enhancer ABC_E4140 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78412317-78412601 Neighboring gene STARR-positive B cell enhancer ABC_E9915 Neighboring gene STARR-positive B cell enhancer ABC_E11597 Neighboring gene STARR-positive B cell enhancer ABC_E2444 Neighboring gene STARR-positive B cell enhancer ABC_E10866 Neighboring gene predicted gene, 52186 Neighboring gene predicted gene, 52187 Neighboring gene predicted gene, 36877

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A crucial role for Arf6 in the response of commissural axons to Slit. Kinoshita-Kawada M, et al. Development, 2019 Feb 4. PMID 30674481, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00017

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytohesin-4
Names
PH, SEC7 and coiled-coil domain-containing protein 4
pleckstrin homology, Sec7 and coiled/coil domains 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028195.3 → NP_082471.2  cytohesin-4

    See identical proteins and their annotated locations for NP_082471.2

    Status: VALIDATED

    Source sequence(s)
    AK152306, AK152909, BY161747
    Consensus CDS
    CCDS27620.1
    UniProtKB/Swiss-Prot
    Q80YW0
    UniProtKB/TrEMBL
    Q3U0C0, Q3U6Y6, Q3U8A6
    Related
    ENSMUSP00000042698.6, ENSMUST00000043069.6
    Conserved Domains (3) summary
    cd01252
    Location:258 → 376
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:262 → 374
    PH; PH domain
    pfam01369
    Location:61 → 243
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78481247..78506219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159605.1 → XP_036015498.1  cytohesin-4 isoform X4

    UniProtKB/TrEMBL
    Q05D35
    Conserved Domains (2) summary
    cd01252
    Location:235 → 353
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:38 → 220
    Sec7; Sec7 domain

  2. XM_006521446.4 → XP_006521509.1  cytohesin-4 isoform X1

    UniProtKB/TrEMBL
    Q3U6Y6, Q3U8A6
    Conserved Domains (2) summary
    cd01252
    Location:255 → 373
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:58 → 240
    Sec7; Sec7 domain

  3. XM_036159606.1 → XP_036015499.1  cytohesin-4 isoform X5

    UniProtKB/TrEMBL
    Q05D35
    Conserved Domains (2) summary
    cd01252
    Location:201 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:4 → 186
    Sec7; Sec7 domain

  4. XM_036159603.1 → XP_036015496.1  cytohesin-4 isoform X2

    Conserved Domains (2) summary
    cd01252
    Location:181 → 299
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:41 → 166
    Sec7; Sec7 domain

  5. XM_036159604.1 → XP_036015497.1  cytohesin-4 isoform X3

    Conserved Domains (2) summary
    cd01252
    Location:174 → 292
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:34 → 159
    Sec7; Sec7 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YW0.1 GenPept UniProtKB/Swiss-Prot:Q80YW0

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