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Sanbr SANT and BTB domain regulator of CSR [ Mus musculus (house mouse) ]

Gene ID: 71675, updated on 27-Nov-2024

Summary

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Official Symbol
Sanbrprovided by MGI
Official Full Name
SANT and BTB domain regulator of CSRprovided by MGI
Primary source
MGI:MGI:1918925
See related
Ensembl:ENSMUSG00000042208 AllianceGenome:MGI:1918925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1841; mKIAA1841; 0610010F05Rik
Summary
Enables identical protein binding activity. Involved in isotype switching. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human SANBR (SANT and BTB domain regulator of CSR). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 9.0), CNS E14 (RPKM 7.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Sanbr in Genome Data Viewer
Location:
11 A3.2; 11 14.33 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23514949..23596409, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23564949..23633681, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene STARR-seq mESC enhancer starr_28916 Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene pseudouridylate synthase 10 Neighboring gene STARR-seq mESC enhancer starr_28923 Neighboring gene reticuloendotheliosis oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination. Zheng S, et al. J Biol Chem, 2021 Jan-Jun. PMID 33831416, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in isotype switching IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isotype switching IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
SANT and BTB domain regulator of class switch recombination

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347242.1 → NP_001334171.1  SANT and BTB domain regulator of class switch recombination isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AI642567, AL672049
    Consensus CDS
    CCDS88137.1
    UniProtKB/Swiss-Prot
    Q68FF0
    Conserved Domains (1) summary
    pfam11822
    Location:1 → 102
    DUF3342; Domain of unknown function (DUF3342)

  2. NM_027860.3 → NP_082136.2  SANT and BTB domain regulator of class switch recombination isoform 1

    See identical proteins and their annotated locations for NP_082136.2

    Status: VALIDATED

    Source sequence(s)
    AK053838, BB522605, BC072622, BC079876, BP759684
    Consensus CDS
    CCDS36119.1
    UniProtKB/Swiss-Prot
    A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
    Related
    ENSMUSP00000136118.2, ENSMUST00000180260.8
    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

RNA

  1. NR_156450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672049

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23514949..23596409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156994.1 → XP_036012887.1  SANT and BTB domain regulator of class switch recombination isoform X3

    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  2. XM_006514811.5 → XP_006514874.1  SANT and BTB domain regulator of class switch recombination isoform X3

    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  3. XM_036156993.1 → XP_036012886.1  SANT and BTB domain regulator of class switch recombination isoform X2

    UniProtKB/TrEMBL
    M0QWF3
    Related
    ENSMUSP00000137799.2, ENSMUST00000155903.8
    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  4. XM_036156995.1 → XP_036012888.1  SANT and BTB domain regulator of class switch recombination isoform X4

    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  5. XM_017314769.3 → XP_017170258.1  SANT and BTB domain regulator of class switch recombination isoform X4

    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  6. XM_006514808.4 → XP_006514871.1  SANT and BTB domain regulator of class switch recombination isoform X1

    See identical proteins and their annotated locations for XP_006514871.1

    UniProtKB/Swiss-Prot
    A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  7. XM_030246329.1 → XP_030102189.1  SANT and BTB domain regulator of class switch recombination isoform X5

    Related
    ENSMUSP00000090955.5, ENSMUST00000093267.11
    Conserved Domains (1) summary
    pfam11822
    Location:1 → 102
    DUF3342; Domain of unknown function (DUF3342)

  8. XM_030246327.1 → XP_030102187.1  SANT and BTB domain regulator of class switch recombination isoform X1

    UniProtKB/Swiss-Prot
    A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
    Related
    ENSMUSP00000044265.7, ENSMUST00000043356.13
    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  9. XM_011243749.3 → XP_011242051.1  SANT and BTB domain regulator of class switch recombination isoform X1

    See identical proteins and their annotated locations for XP_011242051.1

    UniProtKB/Swiss-Prot
    A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

  10. XM_017314768.3 → XP_017170257.1  SANT and BTB domain regulator of class switch recombination isoform X1

    UniProtKB/Swiss-Prot
    A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
    Conserved Domains (1) summary
    pfam11822
    Location:147 → 248
    DUF3342; Domain of unknown function (DUF3342)

RNA

  1. XR_004937036.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FF0.2 GenPept UniProtKB/Swiss-Prot:Q68FF0

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