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TLR1 toll like receptor 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574289, updated on 17-Aug-2024

Summary

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Official Symbol
TLR1provided by VGNC
Official Full Name
toll like receptor 1provided by VGNC
Primary source
VGNC:VGNC:78372
See related
Ensembl:ENSMMUG00000016754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See TLR1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (37935710..37945703, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (38445307..38454859, complement)

Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678153 Neighboring gene toll like receptor 10 Neighboring gene toll like receptor 6 Neighboring gene family with sequence similarity 114 member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis. Bernardino AL, et al. Infect Immun, 2008 Oct. PMID 18694963, Free PMC Article
  2. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
  3. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
  4. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.
    Title: Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Toll-like receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipopeptide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to triacyl bacterial lipopeptide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
toll-like receptor 1
NP_001123896.1
XP_028703759.1
XP_028703760.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130424.1 → NP_001123896.1  toll-like receptor 1 precursor

    See identical proteins and their annotated locations for NP_001123896.1

    Status: PROVISIONAL

    Source sequence(s)
    AB445623
    UniProtKB/TrEMBL
    B3Y611, B6CJY6, G7MSR1
    Conserved Domains (6) summary
    smart00082
    Location:524 → 577
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:636 → 779
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:353 → 474
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:47 → 70
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:352 → 373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:69 → 124
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041758.1 Reference Mmul_10 Primary Assembly

    Range
    37935710..37945703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028847927.1 → XP_028703760.1  toll-like receptor 1 isoform X1

    UniProtKB/TrEMBL
    B6CJY6, F7AIC3
    Conserved Domains (7) summary
    smart00082
    Location:524 → 577
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:636 → 779
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:352 → 560
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:12 → 268
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:47 → 70
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:352 → 373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:70 → 124
    LRR_8; Leucine rich repeat

  2. XM_028847926.1 → XP_028703759.1  toll-like receptor 1 isoform X1

    UniProtKB/TrEMBL
    B6CJY6, F7AIC3
    Related
    ENSMMUP00000078776.1, ENSMMUT00000098521.1
    Conserved Domains (7) summary
    smart00082
    Location:524 → 577
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:636 → 779
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:352 → 560
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:12 → 268
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:47 → 70
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:352 → 373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:70 → 124
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version

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