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dlg3 discs, large homolog 3 (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 564081, updated on 4-Jan-2025

Summary

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Official Symbol
dlg3provided by ZNC
Official Full Name
discs, large homolog 3 (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-93
See related
Ensembl:ENSDARG00000076796 AllianceGenome:ZFIN:ZDB-GENE-050208-93
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa66c08; fa66e02; fd02c12; fu95c12; im:7138640; wu:fa66c08; wu:fa66e02; wu:fd02c12; wu:fu95c12; si:ch211-276g21.1
Summary
Predicted to enable kinase binding activity. Predicted to act upstream of or within chemical synaptic transmission. Predicted to be located in neuromuscular junction; neuron projection; and plasma membrane. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See dlg3 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33068737..33218105, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32729953..32877822, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 4 Neighboring gene kinase insert domain receptor like Neighboring gene testis expressed 11 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene PDZ domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. König C, et al. Mech Dev, 1999 Aug. PMID 10446262
  2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC162970

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
disks large homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    33068737..33218105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481213.2 → XP_021336888.1  disks large homolog 3 isoform X17

    UniProtKB/TrEMBL
    A0A2R8PXW1, A5PKT0, F6NMH9
    Related
    ENSDARP00000069206.4, ENSDART00000074720.7
    Conserved Domains (2) summary
    cd12029
    Location:19 → 85
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    pfam00625
    Location:175 → 353
    Guanylate_kin; Guanylate kinase

  2. XM_068213371.1 → XP_068069472.1  disks large homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q1J7

  3. XM_021481211.2 → XP_021336886.1  disks large homolog 3 isoform X16

    UniProtKB/TrEMBL
    A0A8M3AS60
    Conserved Domains (5) summary
    cd12029
    Location:502 → 568
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:383 → 467
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:132 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:640 → 818
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:312 → 385
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  4. XM_068213376.1 → XP_068069477.1  disks large homolog 3 isoform X8

    UniProtKB/TrEMBL
    A0A8M9QBK2

  5. XM_021481210.2 → XP_021336885.1  disks large homolog 3 isoform X15

    UniProtKB/TrEMBL
    A0A8M9QPI1
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:658 → 836
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  6. XM_021481209.2 → XP_021336884.1  disks large homolog 3 isoform X14

    UniProtKB/TrEMBL
    A0A8M9QGS9
    Related
    ENSDARP00000073316.6, ENSDART00000078856.7
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:686 → 864
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  7. XM_021481208.2 → XP_021336883.1  disks large homolog 3 isoform X13

    UniProtKB/TrEMBL
    A0A8M9Q5B2
    Conserved Domains (5) summary
    cd12029
    Location:520 → 584
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:694 → 872
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  8. XM_021481198.2 → XP_021336873.1  disks large homolog 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QBJ7
    Conserved Domains (6) summary
    cd12029
    Location:569 → 633
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:450 → 534
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:150 → 234
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:743 → 921
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  9. XM_068213380.1 → XP_068069481.1  disks large homolog 3 isoform X12

    UniProtKB/TrEMBL
    A0A8M9PZT0

  10. XM_068213379.1 → XP_068069480.1  disks large homolog 3 isoform X11

    UniProtKB/TrEMBL
    A0A8M3B0G6

  11. XM_068213374.1 → XP_068069475.1  disks large homolog 3 isoform X6

    UniProtKB/TrEMBL
    A0A8M9QL07

  12. XM_068213377.1 → XP_068069478.1  disks large homolog 3 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AGS5

  13. XM_068213372.1 → XP_068069473.1  disks large homolog 3 isoform X4

    UniProtKB/TrEMBL
    A0A8M9QGS1

  14. XM_068213378.1 → XP_068069479.1  disks large homolog 3 isoform X10

    UniProtKB/TrEMBL
    A0A8M9QPI0

  15. XM_068213373.1 → XP_068069474.1  disks large homolog 3 isoform X5

    UniProtKB/TrEMBL
    A0A8M9QPH5

  16. XM_068213375.1 → XP_068069476.1  disks large homolog 3 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PZS5

  17. XM_068213370.1 → XP_068069471.1  disks large homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QL03

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394917.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    41667..190271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218764.1 → XP_068074865.1  disks large homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q1J7

  2. XM_009291193.4 → XP_009289468.1  disks large homolog 3 isoform X16

    UniProtKB/TrEMBL
    A0A8M3AS60
    Conserved Domains (5) summary
    cd12029
    Location:502 → 568
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:383 → 467
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:132 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:640 → 818
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:312 → 385
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  3. XM_068218769.1 → XP_068074870.1  disks large homolog 3 isoform X8

    UniProtKB/TrEMBL
    A0A8M9QBK2

  4. XM_009291192.4 → XP_009289467.1  disks large homolog 3 isoform X15

    UniProtKB/TrEMBL
    A0A8M9QPI1
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:658 → 836
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  5. XM_021472851.2 → XP_021328526.1  disks large homolog 3 isoform X14

    UniProtKB/TrEMBL
    A0A8M9QGS9
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:686 → 864
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  6. XM_021472850.2 → XP_021328525.1  disks large homolog 3 isoform X13

    UniProtKB/TrEMBL
    A0A8M9Q5B2
    Conserved Domains (5) summary
    cd12029
    Location:520 → 584
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:694 → 872
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  7. XM_021472842.2 → XP_021328517.1  disks large homolog 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QBJ7
    Conserved Domains (6) summary
    cd12029
    Location:569 → 633
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:450 → 534
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:150 → 234
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:743 → 921
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:330 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:109 → 149
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  8. XM_068218773.1 → XP_068074874.1  disks large homolog 3 isoform X12

    UniProtKB/TrEMBL
    A0A8M9PZT0

  9. XM_068218772.1 → XP_068074873.1  disks large homolog 3 isoform X11

    UniProtKB/TrEMBL
    A0A8M3B0G6

  10. XM_068218767.1 → XP_068074868.1  disks large homolog 3 isoform X6

    UniProtKB/TrEMBL
    A0A8M9QL07

  11. XM_068218770.1 → XP_068074871.1  disks large homolog 3 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AGS5

  12. XM_068218765.1 → XP_068074866.1  disks large homolog 3 isoform X4

    UniProtKB/TrEMBL
    A0A8M9QGS1

  13. XM_068218771.1 → XP_068074872.1  disks large homolog 3 isoform X10

    UniProtKB/TrEMBL
    A0A8M9QPI0

  14. XM_068218766.1 → XP_068074867.1  disks large homolog 3 isoform X5

    UniProtKB/TrEMBL
    A0A8M9QPH5

  15. XM_068218768.1 → XP_068074869.1  disks large homolog 3 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PZS5

  16. XM_068218763.1 → XP_068074864.1  disks large homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QL03

  17. XM_009291194.4 → XP_009289469.1  disks large homolog 3 isoform X17

    See identical proteins and their annotated locations for XP_009289469.1

    UniProtKB/TrEMBL
    A0A2R8PXW1, A5PKT0, F6NMH9
    Conserved Domains (2) summary
    cd12029
    Location:19 → 85
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    pfam00625
    Location:175 → 353
    Guanylate_kin; Guanylate kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001098742.1: Suppressed sequence

    Description
    NM_001098742.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DLG3 (GeneID:1741).
Nucleotide Protein Strain
Heading Accession and Version

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