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atf7ip activating transcription factor 7 interacting protein [ Danio rerio (zebrafish) ]

Gene ID: 558977, updated on 4-Jan-2025

Summary

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Official Symbol
atf7ipprovided by ZNC
Official Full Name
activating transcription factor 7 interacting proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061103-178
See related
Ensembl:ENSDARG00000069619 AllianceGenome:ZFIN:ZDB-GENE-061103-178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa12g02; wu:fa12g02; zgc:152981
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in protein stabilization and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See atf7ip in Genome Data Viewer
Location:
chromosome: 1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (45570062..45614481, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (44878267..44922686, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:ch211-243a20.3 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b Neighboring gene uncharacterized LOC137495816 Neighboring gene septin 3 Neighboring gene small integral membrane protein 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptomic Analysis of Purified Embryonic Neural Stem Cells from Zebrafish Embryos Reveals Signaling Pathways Involved in Glycine-Dependent Neurogenesis. Samarut E, et al. Front Mol Neurosci, 2016. PMID 27065799, Free PMC Article
  2. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. Ko S, et al. J Hepatol, 2016 Feb. PMID 26505118, Free PMC Article
  3. Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Wu J, et al. Proc Natl Acad Sci U S A, 2023 Jan 3. PMID 36577070, Free PMC Article
  4. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
  5. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Xue Y, et al. Cell Rep, 2019 Apr 30. PMID 31042481

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation.
    Title: Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC152981

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
activating transcription factor 7-interacting protein 1
Names
MBD1-containing chromatin-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077603.2 → NP_001071071.2  activating transcription factor 7-interacting protein 1

    Status: VALIDATED

    Source sequence(s)
    BX537268, EB936980
    UniProtKB/TrEMBL
    A0A8N7UYD8, F8W5Q4
    Related
    ENSDARP00000125013.1, ENSDART00000149155.3
    Conserved Domains (3) summary
    pfam09184
    Location:82 → 227
    PPP4R2; PPP4R2
    pfam16788
    Location:265 → 431
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:741 → 846
    fn3_4; Fibronectin-III type domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    45570062..45614481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160043.5 → XP_005160100.1  activating transcription factor 7-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005160100.1

    UniProtKB/TrEMBL
    A0A0R4IKD6, A0A8M2B6V3
    Conserved Domains (3) summary
    pfam16788
    Location:223 → 387
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:699 → 804
    fn3_4; Fibronectin-III type domain
    cl25732
    Location:56 → 308
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021475024.2 → XP_021330699.1  activating transcription factor 7-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0R4IKD6, A0A8M2B6V3
    Conserved Domains (3) summary
    pfam16788
    Location:223 → 387
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:699 → 804
    fn3_4; Fibronectin-III type domain
    cl25732
    Location:56 → 308
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_068219647.1 → XP_068075748.1  activating transcription factor 7-interacting protein 1 isoform X5

    UniProtKB/Swiss-Prot
    A0JME2, A2BH15
    Related
    ENSDARP00000122892.1, ENSDART00000135089.3

  4. XM_005160044.5 → XP_005160101.1  activating transcription factor 7-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005160101.1

    UniProtKB/TrEMBL
    A0A0R4IKD6, A0A8M2B6V3
    Conserved Domains (3) summary
    pfam16788
    Location:223 → 387
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:699 → 804
    fn3_4; Fibronectin-III type domain
    cl25732
    Location:56 → 308
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_021475019.2 → XP_021330694.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q0G7
    Conserved Domains (2) summary
    pfam16788
    Location:266 → 430
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:742 → 847
    fn3_4; Fibronectin-III type domain

  6. XM_005160041.4 → XP_005160098.1  activating transcription factor 7-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6X0
    Conserved Domains (3) summary
    pfam09184
    Location:84 → 229
    PPP4R2; PPP4R2
    pfam16788
    Location:267 → 433
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:743 → 848
    fn3_4; Fibronectin-III type domain

  7. XM_068219634.1 → XP_068075735.1  activating transcription factor 7-interacting protein 1 isoform X3

  8. XM_005160045.5 → XP_005160102.1  activating transcription factor 7-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005160102.1

    UniProtKB/TrEMBL
    A0A0R4IKD6, A0A8M2B6V3
    Conserved Domains (3) summary
    pfam16788
    Location:223 → 387
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:699 → 804
    fn3_4; Fibronectin-III type domain
    cl25732
    Location:56 → 308
    SMC_N; RecF/RecN/SMC N terminal domain

  9. XM_005160048.5 → XP_005160105.1  activating transcription factor 7-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005160105.1

    UniProtKB/TrEMBL
    A0A0R4IKD6, A0A8M2B6V3
    Related
    ENSDARP00000136294.2, ENSDART00000160961.2
    Conserved Domains (3) summary
    pfam16788
    Location:223 → 387
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:699 → 804
    fn3_4; Fibronectin-III type domain
    cl25732
    Location:56 → 308
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JME2.2 GenPept UniProtKB/Swiss-Prot:A0JME2

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