mov10b.2 Mov10 RNA helicase b, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mov10b.2provided by ZNC
Official Full Name: Mov10 RNA helicase b, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-371
See related: Ensembl:ENSDARG00000056065 AllianceGenome:ZFIN:ZDB-GENE-060526-371
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mov10b; si:dkeyp-38g6.3
Summary: Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization. Predicted to act upstream of or within regulatory ncRNA-mediated gene silencing. Predicted to be located in P-body. Predicted to be active in P granule and cytosol. Is expressed in eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (27630692..27656765, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (27611239..27637626, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-3' RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in miRNA-mediated gene silencing by mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative helicase mov-10-B.2

Names: Moloney leukemia virus 10, homolog b, tandem duplicate 2; Moloney leukemia virus 10, homolog, b.2; Moloney leukemia virus 10b, tandem duplicate 2; putative helicase mov-10-B

NP_001037805.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044340.2 → NP_001037805.1 putative helicase mov-10-B.2

See identical proteins and their annotated locations for NP_001037805.1

Status: PROVISIONAL

Source sequence(s)

BX323059

UniProtKB/Swiss-Prot

Q1LXK5

Related

ENSDARP00000072953.3, ENSDART00000078491.4

Conserved Domains (5) summary

COG1112
Location:642 → 983

DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]

pfam13086
Location:552 → 718

AAA_11; AAA domain

pfam13087
Location:725 → 948

AAA_12; AAA domain

pfam14646
Location:189 → 262

MYCBPAP; MYCBP-associated protein family

cl21455
Location:552 → 714

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases