|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
531-760 |
7.51e-108 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 334.20 E-value: 7.51e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 531 NFQQYSAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEHVDAHkIY 610
Cdd:cd18038 3 NDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALVTKRE-IL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 611 RLYASSRNQKDIPKILKDNCNV-DEEMIDFPCKEDLMSYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVESETII 689
Cdd:cd18038 82 RLNAPSRDRASVPPELLPYCNSkAEGTFRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEALI 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113195612 690 SVAGLLNAEkGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMTQNDLYKrgDVEFDNRYVSKLIMNYR 760
Cdd:cd18038 162 PLSELASKN-TQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYK--DGEYNPSYITKLLKNYR 229
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
725-948 |
8.57e-65 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 217.03 E-value: 8.57e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 725 LDVSLLERLMTQNDlykrgdvefdnRYVSKLIMNYRSHPYILEVPNRLFYDGELKaCADEISSNQYCMWEHLPSKGFPVI 804
Cdd:pfam13087 1 LDRSLFERLQELGP-----------SAVVMLDTQYRMHPEIMEFPSKLFYGGKLK-DGPSVAERPLPDDFHLPDPLGPLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 805 FHGVPGKDERESNS-PSFFNIYEINILVDYLKKLLLTQPKKgisrifPKDIGIIAPYRKQVEKIKRAIDadkdfQDYMGI 883
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRKLLK-----RKLGGK 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113195612 884 DNLKVGSVEEFQGQERKVIMVSTVRSSvkyisldETFNIGFLKNEKRFNVAVTRAKSLLIMVGNP 948
Cdd:pfam13087 138 LEIEVNTVDGFQGREKDVIIFSCVRSN-------EKGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
761-964 |
3.85e-62 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 209.01 E-value: 3.85e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 761 SHPYILEVPNRLFYDGELKACADEISSnqyCMWEHLPSKGFPVIFHGVPGKDERESNSPSFFNIYEINILVDYLKKLLLt 840
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAAR---LNPPPLPGPSKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLLK- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 841 qpkkgiSRIFPKDIGIIAPYRKQVEKIKRAIDadkdfQDYMGIDNLKVGSVEEFQGQERKVIMVSTVRSSVKYISldetf 920
Cdd:cd18808 77 ------SGVKPSSIGVITPYRAQVALIRELLR-----KRGGLLEDVEVGTVDNFQGREKDVIILSLVRSNESGGS----- 140
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 113195612 921 nIGFLKNEKRFNVAVTRAKSLLIMVGNPMILRTDESWGRFIDFC 964
Cdd:cd18808 141 -IGFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYL 183
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
605-964 |
6.61e-57 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 211.91 E-value: 6.61e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 605 DAHKIYRLYASSRNQKDIPKILKDNCNVDEEMIDFPCKEDLMSYKILICTLVTAGRLVtgGFSEDHFTHNFVDEAGHAVE 684
Cdd:COG1112 492 HPEELEKLIAELREAARLRRALRRELKKRRELRKLLWDALLELAPVVGMTPASVARLL--PLGEGSFDLVIIDEASQATL 569
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 685 SETIISvagLLNAEkgQLVLAGDPKQLGPILRSPLAI---NHGLDVSLLERLMtqndlykrgdvefdNRYVSKLIM---N 758
Cdd:COG1112 570 AEALGA---LARAK--RVVLVGDPKQLPPVVFGEEAEevaEEGLDESLLDRLL--------------ARLPERGVMlreH 630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 759 YRSHPYILEVPNRLFYDGELKACADEISsnqycmwEHLPSKGFPVIFHGVPGKDERESNSPSffNIYEINILVDYLKKLL 838
Cdd:COG1112 631 YRMHPEIIAFSNRLFYDGKLVPLPSPKA-------RRLADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL 701
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 839 LTQPKkgisrifPKDIGIIAPYRKQVEKIKRAIDADKDfqdyMGIDNLKVGSVEEFQGQERKVIMVSTVRSSVKyislDE 918
Cdd:COG1112 702 EDGPD-------GESIGVITPYRAQVALIRELLREALG----DGLEPVFVGTVDRFQGDERDVIIFSLVYSNDE----DV 766
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 113195612 919 TFNIGFL-KNEKRFNVAVTRAKSLLIMVGNPMILRTDES---WGRFIDFC 964
Cdd:COG1112 767 PRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSDPStpaLKRLLEYL 816
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
551-970 |
2.25e-46 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 177.31 E-value: 2.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 551 YLVFGPPGTGKTVTIVEAIKQVEKNIPDayILACAPSNSAADQLCEKLIT--------------------------SEHV 604
Cdd:TIGR00376 176 FLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLLERLALcdqkivrlghparllksnkqhsldylIENH 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 605 DAHKIYRLYA---------SSRNQKDIP---------KILKD------------------------NCNVDEEMIDFPCK 642
Cdd:TIGR00376 254 PKYQIVADIRekidelieeRNKKTKPSPqkrrglsdiKILRKalkkreargieslkiasmaewietNKSIDRLLKLLPES 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 643 EDLMSYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVESETIISvagLLNAEKgqLVLAGDPKQLGPILRSPLAin 722
Cdd:TIGR00376 334 EERIMNEILAESDATNSMAGSEILNGQYFDVAVIDEASQAMEPSCLIP---LLKARK--LILAGDHKQLPPTILSHDA-- 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 723 HGLDVSLLERLMTqndlykrgdvEFDNRyVSKLIMNYRSHPYILEVPNRLFYDGELKA---CADeISSNQYCMWEHLPSK 799
Cdd:TIGR00376 407 EELSLTLFERLIK----------EYPER-SRTLNVQYRMNQKIMEFPSREFYNGKLTAhesVAN-ILLRDLPKVEATESE 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 800 -----GFPVIF---HGVPGKDERESNSPSFFNIYEINILVDYLKKLLltqpKKGISrifPKDIGIIAPYRKQVEKIKRAI 871
Cdd:TIGR00376 475 ddletGIPLLFidtSGCELFELKEADSTSKYNPGEAELVSEIIQALV----KMGVP---ANDIGVITPYDAQVDLLRQLL 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 872 DADKdfqdymgIDnLKVGSVEEFQGQERKVIMVSTVRSsvkyislDETFNIGFLKNEKRFNVAVTRAKSLLIMVGNPMIL 951
Cdd:TIGR00376 548 EHRH-------ID-IEVSSVDGFQGREKEVIIISFVRS-------NRKGEVGFLKDLRRLNVALTRARRKLIVIGDSRTL 612
|
490
....*....|....*....
gi 113195612 952 RTDESWGRFIDFCLERGGY 970
Cdd:TIGR00376 613 SNHKFYKRLIEWCKQHGEV 631
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
552-718 |
1.43e-19 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 89.33 E-value: 1.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQ-----VEKNIPDAYILACAPSNSAADQLCEKLI------------------TSEHVDAHK 608
Cdd:pfam13086 17 LIQGPPGTGKTTTIVELIRQllsypATSAAAGPRILVCAPSNAAVDNILERLLrkgqkygpkivrighpaaISEAVLPVS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 609 IYRLYASSRNQ-------KDIPKILKDN-------------CNVDEEMIDFPCK------------EDLMSYK------- 649
Cdd:pfam13086 97 LDYLVESKLNNeedaqivKDISKELEKLakalrafekeiivEKLLKSRNKDKSKleqerrklrserKELRKELrrreqsl 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 650 ---------ILICTLVTAGRLVTGGFSedhfthNF----VDEAGHAVESETIIsvaGLLNAEKgQLVLAGDPKQLGPILR 716
Cdd:pfam13086 177 ereildeaqIVCSTLSGAGSRLLSSLA------NFdvviIDEAAQALEPSTLI---PLLRGPK-KVVLVGDPKQLPPTVI 246
|
..
gi 113195612 717 SP 718
Cdd:pfam13086 247 SK 248
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
522-714 |
2.74e-05 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 48.05 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 522 RLFDRK-LEYNFQQYSAVcNIVAGTSKPApyLVFGPPGTGKTVTIVEAIKQVEKNIPDayILACAPSNSAADQLCEKLit 600
Cdd:COG0507 116 ALEPRAgITLSDEQREAV-ALALTTRRVS--VLTGGAGTGKTTTLRALLAALEALGLR--VALAAPTGKAAKRLSEST-- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 601 seHVDA---HK-IYRLYASSRNQKDipkilkdncnvdeemidfpCKEDLMSYKILIctlvtagrlvtggfsedhfthnfV 676
Cdd:COG0507 189 --GIEArtiHRlLGLRPDSGRFRHN-------------------RDNPLTPADLLV-----------------------V 224
|
170 180 190
....*....|....*....|....*....|....*...
gi 113195612 677 DEAGhAVESETIISVAGLLNAEKGQLVLAGDPKQLGPI 714
Cdd:COG0507 225 DEAS-MVDTRLMAALLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
552-653 |
2.14e-04 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 43.63 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEHVDAHKIYRLYASSRNQKDIPKILKDNCN 631
Cdd:smart00487 28 ILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTD 107
|
90 100
....*....|....*....|....*...
gi 113195612 632 V----DEEMIDFPCKE--DLMSYKILIC 653
Cdd:smart00487 108 IlvttPGRLLDLLENDklSLSNVDLVIL 135
|
|
| recD |
TIGR01447 |
exodeoxyribonuclease V, alpha subunit; This family describes the exodeoxyribonuclease V alpha ... |
509-714 |
5.24e-04 |
|
exodeoxyribonuclease V, alpha subunit; This family describes the exodeoxyribonuclease V alpha subunit, RecD. RecD is part of a RecBCD complex. A related family in the Gram-positive bacteria separates in a phylogenetic tree, has an additional N-terminal extension of about 200 residues, and is not supported as a member of a RecBCD complex by neighboring genes. The related family is consequently described by a different model. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273631 [Multi-domain] Cd Length: 582 Bit Score: 43.98 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 509 ASRSLNPVSPPALRLFDRKLEYNFQQYSavcniVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAY---ILACA 585
Cdd:TIGR01447 125 EARKRTAPSAILENLFPLLNEQNWRKTA-----VALALKSNFSLITGGPGTGKTTTVARLLLALVKQSPKQGklrIALAA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 586 PSNSAADQLCEKLITSehvdahkIYRLYASSRNQKDIPkilkdncnvdeemidfpckedlmsykiliCTLVTAGRLVTGG 665
Cdd:TIGR01447 200 PTGKAAARLAESLRKA-------VKNLAAAEALIAALP-----------------------------SEAVTIHRLLGIK 243
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113195612 666 FSEDHFTHN----------FVDEAGHAveseTIISVAGLLNAEKG--QLVLAGDPKQLGPI 714
Cdd:TIGR01447 244 PDTKRFRHHernplpldvlVVDEASMV----DLPLMAKLLKALPPntKLILLGDKNQLPSV 300
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
531-760 |
7.51e-108 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 334.20 E-value: 7.51e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 531 NFQQYSAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEHVDAHkIY 610
Cdd:cd18038 3 NDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALVTKRE-IL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 611 RLYASSRNQKDIPKILKDNCNV-DEEMIDFPCKEDLMSYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVESETII 689
Cdd:cd18038 82 RLNAPSRDRASVPPELLPYCNSkAEGTFRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEALI 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113195612 690 SVAGLLNAEkGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMTQNDLYKrgDVEFDNRYVSKLIMNYR 760
Cdd:cd18038 162 PLSELASKN-TQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYK--DGEYNPSYITKLLKNYR 229
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
531-760 |
1.17e-73 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 242.66 E-value: 1.17e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 531 NFQQYSAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEHVDAHKIY 610
Cdd:cd18078 3 NELQKEAVKRILGGECRPLPYILFGPPGTGKTVTIIEAILQVVYNLPRSRILVCAPSNSAADLVTSRLHESKVLKPGDMV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 611 RLYASSRNQKDIPKILKDNCNVDEEMidfpckEDLMSYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVESETIIS 690
Cdd:cd18078 83 RLNAVNRFESTVIDARKLYCRLGEDL------SKASRHRIVISTCSTAGLLYQMGLPVGHFTHVFVDEAGQATEPESLIP 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113195612 691 VaGLLNAEKGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMtQNDLYKRGDVEF------DNRYVSKLIMNYR 760
Cdd:cd18078 157 L-GLISSRDGQIILAGDPMQLGPVIKSRLASAYGLGVSFLERLM-NRPLYLRDPNRFgesggyNPLLVTKLVDNYR 230
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
725-948 |
8.57e-65 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 217.03 E-value: 8.57e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 725 LDVSLLERLMTQNDlykrgdvefdnRYVSKLIMNYRSHPYILEVPNRLFYDGELKaCADEISSNQYCMWEHLPSKGFPVI 804
Cdd:pfam13087 1 LDRSLFERLQELGP-----------SAVVMLDTQYRMHPEIMEFPSKLFYGGKLK-DGPSVAERPLPDDFHLPDPLGPLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 805 FHGVPGKDERESNS-PSFFNIYEINILVDYLKKLLLTQPKKgisrifPKDIGIIAPYRKQVEKIKRAIDadkdfQDYMGI 883
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRKLLK-----RKLGGK 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113195612 884 DNLKVGSVEEFQGQERKVIMVSTVRSSvkyisldETFNIGFLKNEKRFNVAVTRAKSLLIMVGNP 948
Cdd:pfam13087 138 LEIEVNTVDGFQGREKDVIIFSCVRSN-------EKGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
761-964 |
3.85e-62 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 209.01 E-value: 3.85e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 761 SHPYILEVPNRLFYDGELKACADEISSnqyCMWEHLPSKGFPVIFHGVPGKDERESNSPSFFNIYEINILVDYLKKLLLt 840
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAAR---LNPPPLPGPSKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLLK- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 841 qpkkgiSRIFPKDIGIIAPYRKQVEKIKRAIDadkdfQDYMGIDNLKVGSVEEFQGQERKVIMVSTVRSSVKYISldetf 920
Cdd:cd18808 77 ------SGVKPSSIGVITPYRAQVALIRELLR-----KRGGLLEDVEVGTVDNFQGREKDVIILSLVRSNESGGS----- 140
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 113195612 921 nIGFLKNEKRFNVAVTRAKSLLIMVGNPMILRTDESWGRFIDFC 964
Cdd:cd18808 141 -IGFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYL 183
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
605-964 |
6.61e-57 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 211.91 E-value: 6.61e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 605 DAHKIYRLYASSRNQKDIPKILKDNCNVDEEMIDFPCKEDLMSYKILICTLVTAGRLVtgGFSEDHFTHNFVDEAGHAVE 684
Cdd:COG1112 492 HPEELEKLIAELREAARLRRALRRELKKRRELRKLLWDALLELAPVVGMTPASVARLL--PLGEGSFDLVIIDEASQATL 569
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 685 SETIISvagLLNAEkgQLVLAGDPKQLGPILRSPLAI---NHGLDVSLLERLMtqndlykrgdvefdNRYVSKLIM---N 758
Cdd:COG1112 570 AEALGA---LARAK--RVVLVGDPKQLPPVVFGEEAEevaEEGLDESLLDRLL--------------ARLPERGVMlreH 630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 759 YRSHPYILEVPNRLFYDGELKACADEISsnqycmwEHLPSKGFPVIFHGVPGKDERESNSPSffNIYEINILVDYLKKLL 838
Cdd:COG1112 631 YRMHPEIIAFSNRLFYDGKLVPLPSPKA-------RRLADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL 701
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 839 LTQPKkgisrifPKDIGIIAPYRKQVEKIKRAIDADKDfqdyMGIDNLKVGSVEEFQGQERKVIMVSTVRSSVKyislDE 918
Cdd:COG1112 702 EDGPD-------GESIGVITPYRAQVALIRELLREALG----DGLEPVFVGTVDRFQGDERDVIIFSLVYSNDE----DV 766
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 113195612 919 TFNIGFL-KNEKRFNVAVTRAKSLLIMVGNPMILRTDES---WGRFIDFC 964
Cdd:COG1112 767 PRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSDPStpaLKRLLEYL 816
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
551-970 |
2.25e-46 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 177.31 E-value: 2.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 551 YLVFGPPGTGKTVTIVEAIKQVEKNIPDayILACAPSNSAADQLCEKLIT--------------------------SEHV 604
Cdd:TIGR00376 176 FLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLLERLALcdqkivrlghparllksnkqhsldylIENH 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 605 DAHKIYRLYA---------SSRNQKDIP---------KILKD------------------------NCNVDEEMIDFPCK 642
Cdd:TIGR00376 254 PKYQIVADIRekidelieeRNKKTKPSPqkrrglsdiKILRKalkkreargieslkiasmaewietNKSIDRLLKLLPES 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 643 EDLMSYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVESETIISvagLLNAEKgqLVLAGDPKQLGPILRSPLAin 722
Cdd:TIGR00376 334 EERIMNEILAESDATNSMAGSEILNGQYFDVAVIDEASQAMEPSCLIP---LLKARK--LILAGDHKQLPPTILSHDA-- 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 723 HGLDVSLLERLMTqndlykrgdvEFDNRyVSKLIMNYRSHPYILEVPNRLFYDGELKA---CADeISSNQYCMWEHLPSK 799
Cdd:TIGR00376 407 EELSLTLFERLIK----------EYPER-SRTLNVQYRMNQKIMEFPSREFYNGKLTAhesVAN-ILLRDLPKVEATESE 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 800 -----GFPVIF---HGVPGKDERESNSPSFFNIYEINILVDYLKKLLltqpKKGISrifPKDIGIIAPYRKQVEKIKRAI 871
Cdd:TIGR00376 475 ddletGIPLLFidtSGCELFELKEADSTSKYNPGEAELVSEIIQALV----KMGVP---ANDIGVITPYDAQVDLLRQLL 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 872 DADKdfqdymgIDnLKVGSVEEFQGQERKVIMVSTVRSsvkyislDETFNIGFLKNEKRFNVAVTRAKSLLIMVGNPMIL 951
Cdd:TIGR00376 548 EHRH-------ID-IEVSSVDGFQGREKEVIIISFVRS-------NRKGEVGFLKDLRRLNVALTRARRKLIVIGDSRTL 612
|
490
....*....|....*....
gi 113195612 952 RTDESWGRFIDFCLERGGY 970
Cdd:TIGR00376 613 SNHKFYKRLIEWCKQHGEV 631
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
552-733 |
4.67e-32 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 125.05 E-value: 4.67e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQVEKNIPDAyILACAPSNSAADQLCEKlITSEHVdahKIYRLYASSRNQKDIP-------- 623
Cdd:cd18039 20 LIQGPPGTGKTVTSATIVYHLVKQGNGP-VLVCAPSNVAVDQLTEK-IHQTGL---KVVRLCAKSREAVESPvsflalhn 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 624 --------------KILKDN----CNVDE----EMIDFPCKEDLMSYKILICTLVTAG--RLvtggfSEDHFTHNFVDEA 679
Cdd:cd18039 95 qvrnldsaeklellKLLKLEtgelSSADEkryrKLKRKAERELLRNADVICCTCVGAGdpRL-----SKMKFRTVLIDEA 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 113195612 680 GHAVESETIISVagLLNAEkgQLVLAGDPKQLGPILRSPLAINHGLDVSLLERL 733
Cdd:cd18039 170 TQATEPECLIPL--VHGAK--QVILVGDHCQLGPVVMCKKAAKAGLSQSLFERL 219
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
531-733 |
9.12e-32 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 124.13 E-value: 9.12e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 531 NFQQYSAVCNIVAGTSKPAP-YLVFGPPGTGKTVTIVEAIKQVEKNiPDAYILACAPSNSAAD----QLCEKLITSEHVD 605
Cdd:cd18077 3 NAKQKEAVLAITTPLSIQLPpVLLIGPFGTGKTFTLAQAVKHILQQ-PETRILICTHSNSAADlyikEYLHPYVETGNPR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 606 AhKIYRLYASSRNQKDIPKILKDNCNVDEE-MIDFPCKEDLMSYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVE 684
Cdd:cd18077 82 A-RPLRVYYRNRWVKTVHPVVQKYCLIDEHgTFRMPTREDVMRHRVVVVTLSTSQYLCQLDLEPGFFTHILLDEAAQAME 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 113195612 685 SETIISVAglLNAEKGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERL 733
Cdd:cd18077 161 CEAIMPLA--LATKSTRIVLAGDHMQLSPEVYSEFARERNLHISLLERL 207
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
552-747 |
1.28e-26 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 108.08 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQVEKniPDAYILACAPSNSAADQLCEKLITSehvdAHKIYRLYASSRnqkdipkilkdncn 631
Cdd:cd18044 21 LIHGPPGTGKTTTVVEIILQAVK--RGEKVLACAPSNIAVDNLVERLVAL----KVKVVRIGHPAR-------------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 632 VDEEMIDFpCKEDLMSYKILICTLVTAG-RLVTggfSEDHFTHNFVDEAGHAVESETIISvagLLNAEKgqLVLAGDPKQ 710
Cdd:cd18044 81 LLESVLDH-SLDALVAAQVVLATNTGAGsRQLL---PNELFDVVVIDEAAQALEASCWIP---LLKARR--CILAGDHKQ 151
|
170 180 190
....*....|....*....|....*....|....*..
gi 113195612 711 LGPILRSPLAINHGLDVSLLERLMtqnDLYKRGDVEF 747
Cdd:cd18044 152 LPPTILSDKAARGGLGVTLFERLV---NLYGESVVRM 185
|
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
530-734 |
3.59e-22 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 96.13 E-value: 3.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 530 YNFQQYSAVCNIVAGTSKPApyLVFGPPGTGKTVTIVEAIKQV-----------EKNIPDAY------------ILACAP 586
Cdd:cd18042 1 LNESQLEAIASALQNSPGIT--LIQGPPGTGKTKTIVGILSVLlagkyrkyyekVKKKLRKLqrnlnnkkkknrILVCAP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 587 SNSAADQLCEKLITSehvdahkiyRLYaSSRNQKDIPKILKdncnVDEEMIdfpCKEDLMSYKILICTLVTAG-RLVTgg 665
Cdd:cd18042 79 SNAAVDEIVLRLLSE---------GFL-DGDGRSYKPNVVR----VGRQEL---RASILNEADIVCTTLSSSGsDLLE-- 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113195612 666 fsedHFTHNF----VDEAGHAVESETIISVAglLNAEKgqLVLAGDPKQLGPILRSPLAINHGLDVSLLERLM 734
Cdd:cd18042 140 ----SLPRGFdtviIDEAAQAVELSTLIPLR--LGCKR--LILVGDPKQLPATVFSKVAQKLGYDRSLFERLQ 204
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
552-718 |
1.43e-19 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 89.33 E-value: 1.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQ-----VEKNIPDAYILACAPSNSAADQLCEKLI------------------TSEHVDAHK 608
Cdd:pfam13086 17 LIQGPPGTGKTTTIVELIRQllsypATSAAAGPRILVCAPSNAAVDNILERLLrkgqkygpkivrighpaaISEAVLPVS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 609 IYRLYASSRNQ-------KDIPKILKDN-------------CNVDEEMIDFPCK------------EDLMSYK------- 649
Cdd:pfam13086 97 LDYLVESKLNNeedaqivKDISKELEKLakalrafekeiivEKLLKSRNKDKSKleqerrklrserKELRKELrrreqsl 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 650 ---------ILICTLVTAGRLVTGGFSedhfthNF----VDEAGHAVESETIIsvaGLLNAEKgQLVLAGDPKQLGPILR 716
Cdd:pfam13086 177 ereildeaqIVCSTLSGAGSRLLSSLA------NFdvviIDEAAQALEPSTLI---PLLRGPK-KVVLVGDPKQLPPTVI 246
|
..
gi 113195612 717 SP 718
Cdd:pfam13086 247 SK 248
|
|
| DEXXQc_HELZ2-N |
cd18076 |
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
531-733 |
2.46e-19 |
|
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350834 [Multi-domain] Cd Length: 230 Bit Score: 88.02 E-value: 2.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 531 NFQQYSAVCNIV---AGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNiPDAYILACAPSNSAAD----QLCEKLITSEH 603
Cdd:cd18076 3 NNKQQLAFNFIAgkpSEARFVPPLLIYGPFGTGKTFTLAMAALEVIRE-PGTKVLICTHTNSAADiyirEYFHPYVDKGH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 604 VDAHKIyRLYASSR--NQKDIPKILKDNCNVDEEMIDFPCKEDLMSYKILICTLVTAGRL-VTGGFsedhFTHNFVDEAG 680
Cdd:cd18076 82 PEARPL-RIKATDRpnAITDPDTITYCCLTKDRQCFRLPTRDELDFHNIVITTTAMAFNLhVLSGF----FTHIFIDEAA 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 113195612 681 HAVESETIISVAglLNAEKGQLVLAGDPKQLGPILRSpLAINHGLDVSLLERL 733
Cdd:cd18076 157 QMLECEALIPLS--YAGPKTRVVLAGDHMQMTPKLFS-VADYNRANHTLLNRL 206
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
552-733 |
6.39e-19 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 86.14 E-value: 6.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQVEKNipDAYILACAPSNSAADQLCEKLITsehvDAHKIYRLYASSRNQKDI-----PKIL 626
Cdd:cd18041 21 LILGMPGTGKTTTIAALVRILVAL--GKSVLLTSYTHSAVDNILLKLKK----FGVNFLRLGRLKKIHPDVqeftlEAIL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 627 KDNCNVDEemidfpCKEDLMSYKILICTLVTAGRLVtggFSEDHFTHNFVDEAGHAVESETIISvagLLNAEKgqLVLAG 706
Cdd:cd18041 95 KSCKSVEE------LESKYESVSVVATTCLGINHPI---FRRRTFDYCIVDEASQITLPICLGP---LRLAKK--FVLVG 160
|
170 180
....*....|....*....|....*..
gi 113195612 707 DPKQLGPILRSPLAINHGLDVSLLERL 733
Cdd:cd18041 161 DHYQLPPLVKSREARELGMDESLFKRL 187
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
551-733 |
1.02e-15 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 78.34 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 551 YLVFGPPGTGKTVTIV-----------EAIKQVEKNIPDAYILACAPSNSAADQLCEKLItseHVDAHKIYRLYA----- 614
Cdd:cd18040 19 TLIQGPPGTGKTVTGVhiaywfakqnrEIQSVSGEGDGGPCVLYCGPSNKSVDVVAELLL---KVPGLKILRVYSeqiet 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 615 --------SSRNQKDIPKILKDNCNVD----------------------EEMIDFP----CKEDLMSYK----------- 649
Cdd:cd18040 96 teypipnePRHPNKKSERESKPNSELSsitlhhrirqpsnphsqqikafEARFERTqekiTEEDIKTYKiliwearfeel 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 650 ----ILICTLVTAGrlvTGGFSED-HFTHNFVDEAGHAVESETIISVAGLLNAEkgQLVLAGDPKQLGPILRSPLAINHG 724
Cdd:cd18040 176 etvdVILCTCSEAA---SQKMRTHaNVKQCIVDECGMCTEPESLIPIVSAPRAE--QVVLIGDHKQLRPVVQNKEAQKLG 250
|
....*....
gi 113195612 725 LDVSLLERL 733
Cdd:cd18040 251 LGRSLFERY 259
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
552-734 |
3.35e-14 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 69.96 E-value: 3.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADqlceklitsehvdahkiyrlyassrnqkdipkilkdncN 631
Cdd:cd17934 3 LIQGPPGTGKTTTIAAIVLQLLKGLRGKRVLVTAQSNVAVD--------------------------------------N 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 632 VDeemidfpckedlmsykILIctlvtagrlvtggfsedhfthnfVDEAGHAVESETIIsvaGLLNAEKgqLVLAGDPKQL 711
Cdd:cd17934 45 VD----------------VVI-----------------------IDEASQITEPELLI---ALIRAKK--VVLVGDPKQL 80
|
170 180
....*....|....*....|....*..
gi 113195612 712 GPIL----RSPLAINHGLDVSLLERLM 734
Cdd:cd17934 81 PPVVqedhAALLGLSFILSLLLLFRLL 107
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
526-733 |
5.69e-11 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 63.21 E-value: 5.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 526 RKLEYNFQQYSAvcnIVAGtSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLitsEHVD 605
Cdd:cd17935 2 NTVKFTPTQIEA---IRSG-MQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEKI---MALD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 606 AHKIYRLYASSrnqkdipkilkdncnvdeemidfpckedlmSYKILICTLVTA----GRLVTGGFSEDHFthnFVDEAGH 681
Cdd:cd17935 75 IDERHLLRLGH------------------------------GAKIIAMTCTHAalkrGELVELGFKYDNI---LMEEAAQ 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 113195612 682 AVESETIISVAgLLNAEKG-----QLVLAGDPKQLGPILRSP-LAINHGLDVSLLERL 733
Cdd:cd17935 122 ILEIETFIPLL-LQNPEDGpnrlkRLIMIGDHHQLPPVIKNMaFQKYSNMEQSLFTRL 178
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
534-733 |
1.80e-10 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 61.02 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 534 QYSAVCNIVagTSKPApyLVFGPPGTGKT---VTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEhvdahkiy 610
Cdd:cd17936 6 QLEALKHAL--TSELA--LIQGPPGTGKTflgVKLVRALLQNQDLSITGPILVVCYTNHALDQFLEGLLDFG-------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 611 rlyassrnqkdIPKILKdncnvdeemidfpckedlMSYKILICTLVTAGRLvTGGFSEDHFTHNFVDEAGHAVESETIis 690
Cdd:cd17936 74 -----------PTKIVR------------------LGARVIGMTTTGAAKY-RELLQALGPKVVIVEEAAEVLEAHIL-- 121
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 113195612 691 vAGLLNAEKgQLVLAGDPKQLGPILRSPL--AINHGLDVSLLERL 733
Cdd:cd17936 122 -AALTPSTE-HLILIGDHKQLRPKVNVYEltAKKYNLDVSLFERL 164
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
555-714 |
1.38e-07 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 52.17 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 555 GPPGTGKTVTIVEAIKQVEKNIPDayILACAPSNSAADQLCEklitSEHVDAHKIYRLyassrnqkdipkiLKDNCNVDE 634
Cdd:cd17933 19 GGAGTGKTTTLKALLAALEAEGKR--VVLAAPTGKAAKRLSE----STGIEASTIHRL-------------LGINPGGGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 635 EMIDfpcKEDLMSYKILIctlvtagrlvtggfsedhfthnfVDEAGhAVESETIisvAGLLNA--EKGQLVLAGDPKQLG 712
Cdd:cd17933 80 FYYN---EENPLDADLLI-----------------------VDEAS-MVDTRLM---AALLSAipAGARLILVGDPDQLP 129
|
..
gi 113195612 713 PI 714
Cdd:cd17933 130 SV 131
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
552-599 |
5.43e-07 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 49.41 E-value: 5.43e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQV--EKNIPDAYILACAPSNSAADQLCEKLI 599
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALmqNKNGEPGRILLVTPTNKAAAQLDNILV 52
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
541-612 |
8.00e-06 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 46.44 E-value: 8.00e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113195612 541 IVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAY-ILACAPSNSAADQLCEKLItsehVDAHKIYRL 612
Cdd:pfam13245 4 AVRTALPSKVVLLTGGPGTGKTTTIRHIVALLVALGGVSFpILLAAPTGRAAKRLSERTG----LPASTIHRL 72
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
529-714 |
2.18e-05 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 46.40 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 529 EYNFQQYSAVCNIVAGTSKPApyLVFGPPGTGKTvTIVEAIKQV-EKNIPDayILACAPSNSAADQLCEklitSEHVDAH 607
Cdd:pfam13604 1 TLNAEQAAAVRALLTSGDRVA--VLVGPAGTGKT-TALKALREAwEAAGYR--VIGLAPTGRAAKVLGE----ELGIPAD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 608 KIYRLYASSRNQKDIpkilkdncnvdeemidfpckedlmsykilictlvTAGRLVtggfsedhfthnFVDEAGHaVESET 687
Cdd:pfam13604 72 TIAKLLHRLGGRAGL----------------------------------DPGTLL------------IVDEAGM-VGTRQ 104
|
170 180
....*....|....*....|....*..
gi 113195612 688 IISVAGLLNAEKGQLVLAGDPKQLGPI 714
Cdd:pfam13604 105 MARLLKLAEDAGARVILVGDPRQLPSV 131
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
522-714 |
2.74e-05 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 48.05 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 522 RLFDRK-LEYNFQQYSAVcNIVAGTSKPApyLVFGPPGTGKTVTIVEAIKQVEKNIPDayILACAPSNSAADQLCEKLit 600
Cdd:COG0507 116 ALEPRAgITLSDEQREAV-ALALTTRRVS--VLTGGAGTGKTTTLRALLAALEALGLR--VALAAPTGKAAKRLSEST-- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 601 seHVDA---HK-IYRLYASSRNQKDipkilkdncnvdeemidfpCKEDLMSYKILIctlvtagrlvtggfsedhfthnfV 676
Cdd:COG0507 189 --GIEArtiHRlLGLRPDSGRFRHN-------------------RDNPLTPADLLV-----------------------V 224
|
170 180 190
....*....|....*....|....*....|....*...
gi 113195612 677 DEAGhAVESETIISVAGLLNAEKGQLVLAGDPKQLGPI 714
Cdd:COG0507 225 DEAS-MVDTRLMAALLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
552-653 |
2.14e-04 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 43.63 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 552 LVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEHVDAHKIYRLYASSRNQKDIPKILKDNCN 631
Cdd:smart00487 28 ILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTD 107
|
90 100
....*....|....*....|....*...
gi 113195612 632 V----DEEMIDFPCKE--DLMSYKILIC 653
Cdd:smart00487 108 IlvttPGRLLDLLENDklSLSNVDLVIL 135
|
|
| recD |
TIGR01447 |
exodeoxyribonuclease V, alpha subunit; This family describes the exodeoxyribonuclease V alpha ... |
509-714 |
5.24e-04 |
|
exodeoxyribonuclease V, alpha subunit; This family describes the exodeoxyribonuclease V alpha subunit, RecD. RecD is part of a RecBCD complex. A related family in the Gram-positive bacteria separates in a phylogenetic tree, has an additional N-terminal extension of about 200 residues, and is not supported as a member of a RecBCD complex by neighboring genes. The related family is consequently described by a different model. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273631 [Multi-domain] Cd Length: 582 Bit Score: 43.98 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 509 ASRSLNPVSPPALRLFDRKLEYNFQQYSavcniVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAY---ILACA 585
Cdd:TIGR01447 125 EARKRTAPSAILENLFPLLNEQNWRKTA-----VALALKSNFSLITGGPGTGKTTTVARLLLALVKQSPKQGklrIALAA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 586 PSNSAADQLCEKLITSehvdahkIYRLYASSRNQKDIPkilkdncnvdeemidfpckedlmsykiliCTLVTAGRLVTGG 665
Cdd:TIGR01447 200 PTGKAAARLAESLRKA-------VKNLAAAEALIAALP-----------------------------SEAVTIHRLLGIK 243
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113195612 666 FSEDHFTHN----------FVDEAGHAveseTIISVAGLLNAEKG--QLVLAGDPKQLGPI 714
Cdd:TIGR01447 244 PDTKRFRHHernplpldvlVVDEASMV----DLPLMAKLLKALPPntKLILLGDKNQLPSV 300
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
853-946 |
1.37e-03 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 38.96 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 853 DIGIIAPYRKQVEKIKRAIDA----DKDFQDYmgidnlKVGSVEEFQGQERKVImvstvrssvkYISLDETFnigfLKNE 928
Cdd:cd18786 12 KGVVLTPYHRDRAYLNQYLQGlsldEFDLQLV------GAITIDSSQGLTFDVV----------TLYLPTAN----SLTP 71
|
90
....*....|....*...
gi 113195612 929 KRFNVAVTRAKSLLIMVG 946
Cdd:cd18786 72 RRLYVALTRARKRLVIYD 89
|
|
| DEXXQc_SF1 |
cd18043 |
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ... |
531-716 |
7.24e-03 |
|
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350801 [Multi-domain] Cd Length: 127 Bit Score: 37.56 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 531 NFQQYSAVCNIVAGTSkpapYLVFGPPGTGKTVTIVeaikqveknipdayilacapsNSAADQLCEK---LITSEHVDAh 607
Cdd:cd18043 1 DSSQEAAIISARNGKN----VVIQGPPGTGKSQTIA---------------------NIIANALARGkrvLFVSEKKAA- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195612 608 kiyrLyassrnqkdipkilkdncnvdeEMIDFPCkedlmsykiLICTLVTAGRLVtgGFSEDHFTHNFVDEAGHAveseT 687
Cdd:cd18043 55 ----L----------------------DVVRFPC---------WIMSPLSVSQYL--PLNRNLFDLVIFDEASQI----P 93
|
170 180
....*....|....*....|....*....
gi 113195612 688 IISVAGLLNAEKgQLVLAGDPKQLGPILR 716
Cdd:cd18043 94 IEEALPALFRGK-QVVVVGDDKQLPPSIL 121
|
|
| |
