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PPOX protoporphyrinogen oxidase [ Homo sapiens (human) ]

Gene ID: 5498, updated on 27-Nov-2024

Summary

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Official Symbol
PPOXprovided by HGNC
Official Full Name
protoporphyrinogen oxidaseprovided by HGNC
Primary source
HGNC:HGNC:9280
See related
Ensembl:ENSG00000143224 MIM:600923; AllianceGenome:HGNC:9280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VP; PPO; VPCO; V290M
Summary
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.3), skin (RPKM 3.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See PPOX in Genome Data Viewer
Location:
1q23.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161165728..161178013)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160303185..160315736)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161136216..161141010)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:161123368-161124567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1470 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161137271-161137934 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161146985-161147484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161148623-161149124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1983 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161162728-161163541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161166678-161167583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161170109-161170830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1985 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161187006-161187992 Neighboring gene Fc epsilon receptor Ig

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Extended haplotype studies in South African and Dutch variegate porphyria families carrying the recurrent p.R59W mutation confirm a common ancestry. van Tuyll van Serooskerken AM, et al. Br J Dermatol, 2012 Feb. PMID 21910705
  2. Homozygous variegate porphyria in South Africa: genotypic analysis in two cases. Corrigall AV, et al. Mol Genet Metab, 2000 Apr. PMID 10870850
  3. Homozygous variegate porphyria: 20 y follow-up and characterization of molecular defect. Kauppinen R, et al. J Invest Dermatol, 2001 Apr. PMID 11286631
  4. Clinical and biochemical characteristics and genotype-phenotype correlation in Finnish variegate porphyria patients. von und zu Fraunberg M, et al. Eur J Hum Genet, 2002 Oct. PMID 12357337
  5. Homozygous variegate porphyria: a compound heterozygote with novel mutations in the protoporphyrinogen oxidase gene. Palmer RA, et al. Br J Dermatol, 2001 Apr. PMID 11298551

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular characterization of a novel His333Arg variant of human protoporphyrinogen oxidase IX.
    Title: Molecular characterization of a novel His333Arg variant of human protoporphyrinogen oxidase IX.
  2. The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.
    Title: The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.
  3. Two new mutations in the PPOX gene in a patient with variegate porphyria.
    Title: Two new mutations in the PPOX gene in a patient with variegate porphyria.
  4. Mount Sinai Porphyrias Diagnostic Laboratory diagnosed 54 unrelated Variegate Porphyria individuals with 20 PPOX novel mutations.
    Title: Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.
  5. The genetic test showed a heterozygous mutation in the gene encoding Protoporphyrinogen Oxidase (PPOX); c.2T > A (p.Met1Lys) on chromosome 1q23, which supports the diagnosis of Variegate Porphyria
    Title: An unusual diagnosis in a 31-year-old man with abdominal pain and hyponatremia.
  6. the regulation of PPOX gene expression can also occur through a post-transcriptional modulation of the amount of gene product and this modulation can be mediated by 5' untranslated exon 1.
    Title: The assessment of noncoding variant of PPOX gene in variegate porphyria reveals post-transcriptional role of the 5' untranslated exon 1.
  7. GAPDH and protoporphyrinogen oxidase were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH or PPOX reduced the growth of colon cancer cells in vitro
    Title: Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
  8. Variegate porphyria is the result of decreased protoporphyrinogen oxidase activity. Diet supplementation with vitamins E and C restores PPOX gene expression in lymphocytes of variegate porphyria patients.
    Title: Antioxidants restore protoporphyrinogen oxidase in variegate porphyria patients.
  9. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX and HMBS
    Title: Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
  10. The mutation 1082-1083insC(1 base pair insertion at position 1082) in exon 10 of the PPOX gene was prevalent in the Swiss population.
    Title: Identification of a recurrent mutation in the protoporphyrinogen oxidase gene in Swiss patients with variegate porphyria: clinical and genetic implications.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Variegate porphyria
MedGen: C0162532 OMIM: 176200 GeneReviews: Variegate Porphyria
Compare labs
Variegate porphyria, childhood-onset
MedGen: C5882681 OMIM: 620483 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8485

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding TAS
Traceable Author Statement
more info
 PubMed 
enables menaquinone-dependent protoporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxygen-dependent protoporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen-dependent protoporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heme B biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heme O biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial intermembrane space TAS
Traceable Author Statement
more info
  
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
protoporphyrinogen oxidase
NP_000300.1
NP_001116236.1
NP_001337057.1
NP_001337058.1
NP_001337059.1
NP_001337060.1
NP_001352327.1
NP_001352328.1
NP_001352329.1
NP_001352330.1
XP_005245348.2
XP_005245352.2
XP_006711467.3
XP_011507965.1
XP_011507966.1
XP_011507967.1
XP_011507969.1
XP_011507970.1
XP_011507972.1
XP_011507973.1
XP_011507974.2
XP_011507975.1
XP_011507976.1
XP_011507980.1
XP_016857055.1
XP_024303632.2
XP_047279525.1
XP_047279537.1
XP_047279548.1
XP_047279560.1
XP_054193244.1
XP_054193245.1
XP_054193246.1
XP_054193247.1
XP_054193248.1
XP_054193249.1
XP_054193250.1
XP_054193251.1
XP_054193252.1
XP_054193253.1
XP_054193254.1
XP_054193255.1
XP_054193256.1
XP_054193257.1
XP_054193258.1
XP_054193259.1
XP_054193260.1
XP_054193261.1
XP_054193262.1
XP_054193263.1
XP_054193264.1
XP_054193265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012877.2 RefSeqGene

    Range
    5036..9830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1078

mRNA and Protein(s)

  1. NM_000309.5 → NP_000300.1  protoporphyrinogen oxidase isoform 1

    See identical proteins and their annotated locations for NP_000300.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AI357309, BC002357
    Consensus CDS
    CCDS1221.1
    UniProtKB/Swiss-Prot
    D3DVG0, P50336, Q5VTW8
    UniProtKB/TrEMBL
    A0A494C146
    Related
    ENSP00000343943.5, ENST00000352210.9
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

  2. NM_001122764.3 → NP_001116236.1  protoporphyrinogen oxidase isoform 1

    See identical proteins and their annotated locations for NP_001116236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AI357309, BC002357, BX384814
    Consensus CDS
    CCDS1221.1
    UniProtKB/Swiss-Prot
    D3DVG0, P50336, Q5VTW8
    UniProtKB/TrEMBL
    A0A494C146
    Related
    ENSP00000356978.4, ENST00000367999.9
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

  3. NM_001350128.2 → NP_001337057.1  protoporphyrinogen oxidase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AI357309, AL590714, BC002357, BX384814, DC399187
    UniProtKB/TrEMBL
    A0A494C0D4, B4DY76
    Conserved Domains (1) summary
    cl27533
    Location:3 → 438
    HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]

  4. NM_001350129.2 → NP_001337058.1  protoporphyrinogen oxidase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: Variants 4 and 9 encode the same protein (isoform 3).
    Source sequence(s)
    AI357309, BC002357, DA061615, DA745403, DC399187
    UniProtKB/TrEMBL
    A0A494C0D4
    Conserved Domains (1) summary
    TIGR00562
    Location:30 → 335
    proto_IX_ox; protoporphyrinogen oxidase

  5. NM_001350130.2 → NP_001337059.1  protoporphyrinogen oxidase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: Variants 5, 6 and 10 encode the same protein (isoform 4).
    Source sequence(s)
    AI357309, BC002357, EL954312
    UniProtKB/TrEMBL
    A0A494C0D4
    Conserved Domains (1) summary
    TIGR00562
    Location:4 → 309
    proto_IX_ox; protoporphyrinogen oxidase

  6. NM_001350131.2 → NP_001337060.1  protoporphyrinogen oxidase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: Variants 5, 6 and 10 encode the same protein (isoform 4).
    Source sequence(s)
    AI357309, BC002357, DA268550
    UniProtKB/TrEMBL
    A0A494C0D4
    Conserved Domains (1) summary
    TIGR00562
    Location:4 → 309
    proto_IX_ox; protoporphyrinogen oxidase

  7. NM_001365398.1 → NP_001352327.1  protoporphyrinogen oxidase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AL590714
    Consensus CDS
    CCDS1221.1
    UniProtKB/Swiss-Prot
    D3DVG0, P50336, Q5VTW8
    UniProtKB/TrEMBL
    A0A494C146
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

  8. NM_001365399.1 → NP_001352328.1  protoporphyrinogen oxidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL590714
    UniProtKB/TrEMBL
    A0A494C146
    Related
    ENSP00000498884.1, ENST00000652182.1
    Conserved Domains (1) summary
    COG1232
    Location:5 → 434
    HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]

  9. NM_001365400.1 → NP_001352329.1  protoporphyrinogen oxidase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: Variants 4 and 9 encode the same protein (isoform 3).
    Source sequence(s)
    AL590714
    UniProtKB/TrEMBL
    A0A494C0D4
    Conserved Domains (1) summary
    TIGR00562
    Location:30 → 335
    proto_IX_ox; protoporphyrinogen oxidase

  10. NM_001365401.1 → NP_001352330.1  protoporphyrinogen oxidase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: Variants 5, 6 and 10 encode the same protein (isoform 4).
    Source sequence(s)
    AL590714
    UniProtKB/TrEMBL
    A0A494C0D4
    Conserved Domains (1) summary
    TIGR00562
    Location:4 → 309
    proto_IX_ox; protoporphyrinogen oxidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161165728..161178013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423581.1 → XP_047279537.1  protoporphyrinogen oxidase isoform X5

  2. XM_011509674.3 → XP_011507976.1  protoporphyrinogen oxidase isoform X12

    Conserved Domains (2) summary
    COG1232
    Location:43 → 317
    HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

  3. XM_011509670.3 → XP_011507972.1  protoporphyrinogen oxidase isoform X6

    Conserved Domains (2) summary
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:232 → 366
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_011509673.3 → XP_011507975.1  protoporphyrinogen oxidase isoform X11

    Conserved Domains (2) summary
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:182 → 316
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. XM_011509663.3 → XP_011507965.1  protoporphyrinogen oxidase isoform X1

    Conserved Domains (2) summary
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:270 → 404
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  6. XM_011509665.3 → XP_011507967.1  protoporphyrinogen oxidase isoform X3

    Conserved Domains (2) summary
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:270 → 404
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_011509664.2 → XP_011507966.1  protoporphyrinogen oxidase isoform X2

    Conserved Domains (2) summary
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:265 → 399
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  8. XM_047423569.1 → XP_047279525.1  protoporphyrinogen oxidase isoform X4

  9. XM_011509671.2 → XP_011507973.1  protoporphyrinogen oxidase isoform X9

    UniProtKB/TrEMBL
    A0A494C146
    Conserved Domains (3) summary
    TIGR00562
    Location:41 → 509
    proto_IX_ox; protoporphyrinogen oxidase
    pfam13450
    Location:45 → 103
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:265 → 399
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  10. XM_011509672.4 → XP_011507974.2  protoporphyrinogen oxidase isoform X10

    UniProtKB/TrEMBL
    B4DY76

  11. XM_006711404.5 → XP_006711467.3  protoporphyrinogen oxidase isoform X8

  12. XM_024447864.2 → XP_024303632.2  protoporphyrinogen oxidase isoform X13

    Related
    ENSP00000498501.1, ENST00000652103.1

  13. XM_011509667.3 → XP_011507969.1  protoporphyrinogen oxidase isoform X5

    See identical proteins and their annotated locations for XP_011507969.1

    Conserved Domains (2) summary
    pfam13450
    Location:7 → 65
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:232 → 366
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  14. XM_005245291.5 → XP_005245348.2  protoporphyrinogen oxidase isoform X7

    See identical proteins and their annotated locations for XP_005245348.2

    Conserved Domains (2) summary
    pfam13450
    Location:7 → 65
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:227 → 361
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  15. XM_011509668.3 → XP_011507970.1  protoporphyrinogen oxidase isoform X5

    See identical proteins and their annotated locations for XP_011507970.1

    Conserved Domains (2) summary
    pfam13450
    Location:7 → 65
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:232 → 366
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  16. XM_005245295.4 → XP_005245352.2  protoporphyrinogen oxidase isoform X14

    See identical proteins and their annotated locations for XP_005245352.2

    UniProtKB/TrEMBL
    B3KT30
    Conserved Domains (1) summary
    TIGR00562
    Location:30 → 236
    proto_IX_ox; protoporphyrinogen oxidase

  17. XM_011509678.2 → XP_011507980.1  protoporphyrinogen oxidase isoform X14

    See identical proteins and their annotated locations for XP_011507980.1

    UniProtKB/TrEMBL
    B3KT30
    Conserved Domains (1) summary
    TIGR00562
    Location:30 → 236
    proto_IX_ox; protoporphyrinogen oxidase

  18. XM_017001566.3 → XP_016857055.1  protoporphyrinogen oxidase isoform X15

    UniProtKB/TrEMBL
    A0A494C0D4
    Conserved Domains (1) summary
    TIGR00562
    Location:30 → 335
    proto_IX_ox; protoporphyrinogen oxidase

  19. XM_047423604.1 → XP_047279560.1  protoporphyrinogen oxidase isoform X16

  20. XM_047423592.1 → XP_047279548.1  protoporphyrinogen oxidase isoform X14

RNA

  1. XR_007061329.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160303185..160315736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337275.1 → XP_054193250.1  protoporphyrinogen oxidase isoform X5

  2. XM_054337282.1 → XP_054193257.1  protoporphyrinogen oxidase isoform X12

  3. XM_054337276.1 → XP_054193251.1  protoporphyrinogen oxidase isoform X6

  4. XM_054337281.1 → XP_054193256.1  protoporphyrinogen oxidase isoform X11

  5. XM_054337269.1 → XP_054193244.1  protoporphyrinogen oxidase isoform X1

  6. XM_054337271.1 → XP_054193246.1  protoporphyrinogen oxidase isoform X3

  7. XM_054337270.1 → XP_054193245.1  protoporphyrinogen oxidase isoform X2

  8. XM_054337272.1 → XP_054193247.1  protoporphyrinogen oxidase isoform X4

  9. XM_054337279.1 → XP_054193254.1  protoporphyrinogen oxidase isoform X9

  10. XM_054337280.1 → XP_054193255.1  protoporphyrinogen oxidase isoform X10

    UniProtKB/TrEMBL
    B4DY76

  11. XM_054337278.1 → XP_054193253.1  protoporphyrinogen oxidase isoform X8

  12. XM_054337284.1 → XP_054193259.1  protoporphyrinogen oxidase isoform X13

  13. XM_054337273.1 → XP_054193248.1  protoporphyrinogen oxidase isoform X5

  14. XM_054337277.1 → XP_054193252.1  protoporphyrinogen oxidase isoform X7

  15. XM_054337274.1 → XP_054193249.1  protoporphyrinogen oxidase isoform X5

  16. XM_054337288.1 → XP_054193263.1  protoporphyrinogen oxidase isoform X14

  17. XM_054337286.1 → XP_054193261.1  protoporphyrinogen oxidase isoform X14

  18. XM_054337283.1 → XP_054193258.1  protoporphyrinogen oxidase isoform X17

  19. XM_054337287.1 → XP_054193262.1  protoporphyrinogen oxidase isoform X14

  20. XM_054337285.1 → XP_054193260.1  protoporphyrinogen oxidase isoform X18

  21. XM_054337289.1 → XP_054193264.1  protoporphyrinogen oxidase isoform X15

  22. XM_054337290.1 → XP_054193265.1  protoporphyrinogen oxidase isoform X16

RNA

  1. XR_008486082.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50336.1 GenPept UniProtKB/Swiss-Prot:P50336

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