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TRIM17 tripartite motif containing 17 [ Homo sapiens (human) ]

Gene ID: 51127, updated on 27-Nov-2024

Summary

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Official Symbol
TRIM17provided by HGNC
Official Full Name
tripartite motif containing 17provided by HGNC
Primary source
HGNC:HGNC:13430
See related
Ensembl:ENSG00000162931 MIM:606123; AllianceGenome:HGNC:13430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBCC; terf; RNF16
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 5.7), spleen (RPKM 1.3) and 11 other tissues See more
Orthologs
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Genomic context

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See TRIM17 in Genome Data Viewer
Location:
1q42.13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228407935..228416861, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227596448..227605374, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228595636..228604562, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene uncharacterized LOC101927401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228555546-228556114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228556115-228556682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557329-228557895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557896-228558461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228578692-228579248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228579249-228579804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228587477-228588152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228589505-228590179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228595439-228596098 Neighboring gene uncharacterized LOC124904537 Neighboring gene microRNA 6742 Neighboring gene tripartite motif containing 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1920 Neighboring gene uncharacterized LOC124904538 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228628090-228628374 Neighboring gene H3.4 histone, cluster member

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. Mandell MA, et al. J Cell Sci, 2016 Oct 1. PMID 27562068, Free PMC Article
  2. MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17. Liu Z, et al. Environ Toxicol, 2022 Nov. PMID 35894553
  3. TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer. Zhong T, et al. Cell Oncol (Dordr), 2023 Oct. PMID 37219768
  4. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Ogawa S, et al. Cytogenet Cell Genet, 2000. PMID 10894938
  5. Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation. Endo H, et al. J Biochem, 2012 Feb. PMID 22023800

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.
    Title: TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.
  2. MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.
    Title: MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.
  3. overexpression of TRIM28 or knock-out of TRIM17 reduced BCLA1 protein levels and restored sensitivity of melanoma cells to BRAF-targeted therapy. Therefore, our data describe a molecular rheostat in which two proteins of the TRIM family antagonistically regulate BCL2A1 stability and modulate cell death.
    Title: TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.
  4. data suggest LSD1 largely plays a tumor suppressor role in luminal breast cancer and the oncogenic program associated with LSD1-inhibition may be suppressed via TRIM37-inhibition
    Title: LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.
  5. deregulation of the TRIM17/TRIM41/ZSCAN21 pathway may be involved in the pathogenesis of Parkinson's disease.
    Title: The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
  6. TRIM17 promoted the removal of midbodies, remnants of the cell division machinery that are known autophagy targets.
    Title: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.
  7. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis
    Title: Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
  8. the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
    Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.
  10. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
    Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM17
Names
RING finger protein terf
RING-type E3 ubiquitin transferase TRIM17
ring finger protein 16
testis RING finger protein
tripartite motif-containing protein 17
NP_001020111.1
NP_001128327.1
NP_057186.1
XP_006711842.1
XP_011542511.1
XP_011542512.1
XP_011542513.1
XP_016856908.1
XP_047278034.1
XP_047278044.1
XP_047278047.1
XP_047278054.1
XP_047278059.1
XP_054192869.1
XP_054192870.1
XP_054192871.1
XP_054192872.1
XP_054192873.1
XP_054192874.1
XP_054192875.1
XP_054192876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024940.3 → NP_001020111.1  E3 ubiquitin-protein ligase TRIM17 isoform 1

    See identical proteins and their annotated locations for NP_001020111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AW770403, BC033788, DA270450
    Consensus CDS
    CCDS1571.1
    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577
    Related
    ENSP00000295033.3, ENST00000295033.7
    Conserved Domains (3) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:13 → 66
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

  2. NM_001134855.2 → NP_001128327.1  E3 ubiquitin-protein ligase TRIM17 isoform 3

    See identical proteins and their annotated locations for NP_001128327.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 3' coding region and UTR, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus that lacks a SPRY domain, compared to isoform 1.
    Source sequence(s)
    AK308774, DC309740
    Consensus CDS
    CCDS44327.1
    UniProtKB/TrEMBL
    B7ZAR4
    Related
    ENSP00000403312.2, ENST00000456946.6
    Conserved Domains (2) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:16 → 65
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. NM_016102.4 → NP_057186.1  E3 ubiquitin-protein ligase TRIM17 isoform 1

    See identical proteins and their annotated locations for NP_057186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AW770403, BC033788, DA270450, DB031719
    Consensus CDS
    CCDS1571.1
    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577
    Related
    ENSP00000355659.2, ENST00000366698.7
    Conserved Domains (3) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:13 → 66
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    228407935..228416861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422088.1 → XP_047278044.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

  2. XM_011544211.4 → XP_011542513.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

    See identical proteins and their annotated locations for XP_011542513.1

    Conserved Domains (3) summary
    cd00021
    Location:70 → 107
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:269 → 445
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cl17238
    Location:4 → 38
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. XM_017001419.2 → XP_016856908.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04, E5RJW6
    Related
    ENSP00000430468.1, ENST00000479800.1
    Conserved Domains (2) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:16 → 65
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  4. XM_011544210.4 → XP_011542512.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_011542512.1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577
    Conserved Domains (3) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:13 → 66
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

  5. XM_047422103.1 → XP_047278059.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04

  6. XM_006711779.4 → XP_006711842.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_006711842.1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577
    Conserved Domains (3) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:13 → 66
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

  7. XM_047422098.1 → XP_047278054.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04

  8. XM_011544209.4 → XP_011542511.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_011542511.1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577
    Conserved Domains (3) summary
    cd00021
    Location:97 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:13 → 66
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

  9. XM_047422091.1 → XP_047278047.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04

  10. XM_047422078.1 → XP_047278034.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577
    Related
    ENSP00000355658.2, ENST00000366697.6

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654708.1 Reference GRCh38.p14 PATCHES

    Range
    1..8060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227596448..227605374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336897.1 → XP_054192872.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

  2. XM_054336898.1 → XP_054192873.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

  3. XM_054336895.1 → XP_054192870.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577

  4. XM_054336894.1 → XP_054192869.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577

  5. XM_054336896.1 → XP_054192871.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    UniProtKB/Swiss-Prot
    B4DVJ2, Q5VST8, Q9Y577

  6. XM_054336901.1 → XP_054192876.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04

  7. XM_054336900.1 → XP_054192875.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04

  8. XM_054336899.1 → XP_054192874.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024941.2: Suppressed sequence

    Description
    NM_001024941.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y577.1 GenPept UniProtKB/Swiss-Prot:Q9Y577

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