fzr fizzy-related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fzrprovided by FlyBase
Official Full Name: fizzy-relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0262699
Locus tag: Dmel_CG3000
See related: AllianceGenome:FB:FBgn0262699
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.193; APC/C; APC/C[Fzr/Cdh1]; cdh1; Cdh1; CDH1; Cdh1/Fzr; Cdh1FZR; Cdh1[Fzr]; Cdh[Fzr]; CG3000; dFZR; Dmel\CG3000; Fxr; Fzr; fzr/cdh1; fzr/Cdh1; Fzr/rap; Hec/Cdh[Fzr]; l(1)G0326; l(1)G0418; rap; rap/fizzy-related; rap/fzr; rap/Fzr; Rap/Fzr; redax; wex
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; gliogenesis; and regulation of mitotic cell cycle. Located in axon; cytoplasm; and microtubule cytoskeleton. Part of anaphase-promoting complex. Is expressed in several structures, including embryonic/larval midgut primordium; eye disc; glial cell; larval brain; and salivary gland body primordium. Used to study developmental and epileptic encephalopathy 109. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 4C11-4C12; 1-8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4667290..4679537, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4561323..4573570, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
Title: Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.
Title: APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.
The transcription factor Myc acts downstream of Fzr during endoreplication in Drosophila salivary gland.
Title: A novel transcriptional cascade is involved in Fzr-mediated endoreplication.
LATS degradation by APC/C(Cdh1) represents a previously unappreciated and evolutionarily conserved layer of Hippo signaling regulation.
Title: Hippo signaling is intrinsically regulated during cell cycle progression by APC/C(Cdh1).
results suggest that, whereas SCF(Ppa) targets the fraction of CENP-A(CID) that is not in complex with Cal1, APC/C(Cdh1) mediates also degradation of the Cal1-CENP-A(CID) complex and, thus, likely contributes to the regulation of centromeric CENP-A(CID) deposition
Title: The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle.
APC/C(Fzr) regulates the fusion of myoblasts as well as the mitotic exit of pericardial cells, cardioblasts and myoblasts.
Title: APC/C(Fzr) regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion.
we show the cell cycle regulator Fizzy-related dictates the decision between mitosis and endocycles. After injury, both cycles accurately restore tissue mass and genome content. However, in response to sustained growth signaling, only endocycles preserve epithelial architecture
Title: Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.
Spd2 is also a novel APC/C Fzr substrate. For the first time demonstrated critical importance of distinct subcellular pools of APC/C activators in the spatiotemporal control of APC/C activity.
Title: Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.
The role for Drosophila APC/C-Cdh1 mediated ubiquitination in regulating synaptic morphology, function and integrity of muscle structure in the peripheral nervous system.
Title: Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion.
when N activity is high, a robust RTK signal operates that uses both Ras and Rap, but when N activity is low, only a mild RTK signal is transduced and Ras alone suffices for the purpose
Title: The role of the small GTPase Rap in Drosophila R7 photoreceptor specification.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fizzy-related

Names: CG3000-PA; CG3000-PB; Cdh1; Fizzy-related; Fizzy-related/Cdh1; fizzy related; fzr-PA; fzr-PB; redax; reduced axons; retina aberrant in pattern; westfalenexpress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4667290..4679537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080113.3 → NP_524852.2 fizzy-related, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524852.2

Status: REVIEWED

UniProtKB/TrEMBL

O18402, Q9W4H9

Related

FBpp0070654

Conserved Domains (3) summary

COG2319
Location:174 → 469

WD40; WD40 repeat [General function prediction only]

cd00200
Location:178 → 456

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:217 → 254

7WD40; WD40 repeat [structural motif]
NM_167013.2 → NP_726941.1 fizzy-related, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726941.1

Status: REVIEWED

UniProtKB/TrEMBL

O18402, Q9W4H9

Related

FBpp0070655

Conserved Domains (3) summary

COG2319
Location:174 → 469

WD40; WD40 repeat [General function prediction only]

cd00200
Location:178 → 456

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:217 → 254

7WD40; WD40 repeat [structural motif]