NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24639729|ref|NP_726941|]
View 

fizzy-related, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
194-457 3.26e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 3.26e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 194 VYLWSACTSQVTRlcDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSD--ILSS 271
Cdd:COG2319 144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 272 GSRDRWIIQRDTRTPQLQseRRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPH 351
Cdd:COG2319 222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 352 HHgLLASGGgtADRCIRFWNTLTGQPMQCVD-TGSQVCNLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 430
Cdd:COG2319 300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*..
gi 24639729 431 VLYLALSPDGEAIVTGAGDETLRFWNV 457
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
194-457 3.26e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 3.26e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 194 VYLWSACTSQVTRlcDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSD--ILSS 271
Cdd:COG2319 144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 272 GSRDRWIIQRDTRTPQLQseRRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPH 351
Cdd:COG2319 222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 352 HHgLLASGGgtADRCIRFWNTLTGQPMQCVD-TGSQVCNLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 430
Cdd:COG2319 300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*..
gi 24639729 431 VLYLALSPDGEAIVTGAGDETLRFWNV 457
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-456 1.87e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 1.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 178 VDWSSQ-NVLAVGLG-SCVYLWSACTSQV-TRLCDLSPDANTVTSVSWnerGNTVAVGTHHGYVTVWDVAANKQINKLNG 254
Cdd:cd00200  15 VAFSPDgKLLATGSGdGTIKVWDLETGELlRTLKGHTGPVRDVAASAD---GTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 255 HSARVGALAWNSD--ILSSGSRDRWIIQRDTRTPQLQseRRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNP 332
Cdd:cd00200  92 HTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 333 VQSYTEHMAAVKAIAWSPHHHGLLASGGgtaDRCIRFWNTLTGQpmqCVDT----GSQVCNLAWSKHSSELVSthGYSQN 408
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGK---CLGTlrghENGVNSVAFSPDGYLLAS--GSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 24639729 409 QILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWN 456
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-326 1.46e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24639729    289 QSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWN 326
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
289-326 1.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24639729   289 QSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWN 326
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 281-457 4.03e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 4.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  281 RDTRTPQLQserrLAGhRQEVCGLKWspdNQYL----ASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLL 356
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICW---NSYIksqvASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLL 591

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  357 ASggGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYL 434
Cdd:PLN00181 592 AS--GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYV 667

                        170       180
                 ....*....|....*....|...
gi 24639729  435 ALSpDGEAIVTGAGDETLRFWNV 457
Cdd:PLN00181 668 RFV-DSSTLVSSSTDNTLKLWDL 689
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
194-457 3.26e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 3.26e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 194 VYLWSACTSQVTRlcDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSD--ILSS 271
Cdd:COG2319 144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 272 GSRDRWIIQRDTRTPQLQseRRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPH 351
Cdd:COG2319 222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 352 HHgLLASGGgtADRCIRFWNTLTGQPMQCVD-TGSQVCNLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 430
Cdd:COG2319 300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*..
gi 24639729 431 VLYLALSPDGEAIVTGAGDETLRFWNV 457
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
138-457 5.42e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 5.42e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 138 VSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTV 217
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 218 TSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSD--ILSSGSRDRWIIQRDTRTPQLQseRRLA 295
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLL--RTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 296 GHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHgLLASGGgtADRCIRFWNTLTG 375
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGS--ADGTVRLWDLATG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 376 QPMQCVDT-GSQVCNLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRF 454
Cdd:COG2319 237 KLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314


                ...
gi 24639729 455 WNV 457
Cdd:COG2319 315 WDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-456 1.87e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 1.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 178 VDWSSQ-NVLAVGLG-SCVYLWSACTSQV-TRLCDLSPDANTVTSVSWnerGNTVAVGTHHGYVTVWDVAANKQINKLNG 254
Cdd:cd00200  15 VAFSPDgKLLATGSGdGTIKVWDLETGELlRTLKGHTGPVRDVAASAD---GTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 255 HSARVGALAWNSD--ILSSGSRDRWIIQRDTRTPQLQseRRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNP 332
Cdd:cd00200  92 HTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 333 VQSYTEHMAAVKAIAWSPHHHGLLASGGgtaDRCIRFWNTLTGQpmqCVDT----GSQVCNLAWSKHSSELVSthGYSQN 408
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGK---CLGTlrghENGVNSVAFSPDGYLLAS--GSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 24639729 409 QILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWN 456
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-465 5.73e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 5.73e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 217 VTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAW--NSDILSSGSRDRWIIQRDTRTPQLQseRRL 294
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECV--RTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 295 AGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHgLLASGGgtADRCIRFWNTLT 374
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSS--QDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 375 GQPMQcVDTG--SQVCNLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETL 452
Cdd:cd00200 167 GKCVA-TLTGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250
                ....*....|...
gi 24639729 453 RFWNVFSKARSQK 465
Cdd:cd00200 244 RVWDLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-457 4.00e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.46  E-value: 4.00e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 252 LNGHSARVGALAWNSD--ILSSGSRDRWIIQRDTRTPQLqsERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHS 329
Cdd:cd00200   5 LKGHTGGVTCVAFSPDgkLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 330 VNPVQSYTEHMAAVKAIAWSPHHHgLLASGGgtADRCIRFWNTLTGQPMQCVDT-GSQVCNLAWSkHSSELVSThGYSQN 408
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVAS-SSQDG 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 24639729 409 QILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNV 457
Cdd:cd00200 158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 290-457 1.07e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 1.07e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 290 SERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGgtaDRCIRF 369
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS---DKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 370 WNTLTGqpmQCVDT----GSQVCNLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVT 445
Cdd:cd00200  78 WDLETG---ECVRTltghTSYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                       170
                ....*....|..
gi 24639729 446 GAGDETLRFWNV 457
Cdd:cd00200 153 SSQDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
263-459 1.26e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 1.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 263 AWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAA 342
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729 343 VKAIAWSPHHHGLLAsggGTADRCIRFWNTLTGQPmqcvdtgsqvcnlawskhsselvsthgysqnqilvwkypsltqVA 422
Cdd:COG2319  81 VLSVAFSPDGRLLAS---ASADGTVRLWDLATGLL-------------------------------------------LR 114

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 24639729 423 KLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFS 459
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-326 1.46e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24639729    289 QSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWN 326
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
289-326 1.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24639729   289 QSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWN 326
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 281-457 4.03e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 4.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  281 RDTRTPQLQserrLAGhRQEVCGLKWspdNQYL----ASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLL 356
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICW---NSYIksqvASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLL 591

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  357 ASggGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYL 434
Cdd:PLN00181 592 AS--GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYV 667

                        170       180
                 ....*....|....*....|...
gi 24639729  435 ALSpDGEAIVTGAGDETLRFWNV 457
Cdd:PLN00181 668 RFV-DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 417-456 3.40e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24639729    417 SLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWN 456
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 217-411 3.42e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  217 VTSVSWNER-GNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNS---DILSSGSRD----RWIIQR------- 281
Cdd:PLN00181 535 LSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDgsvkLWSINQgvsigti 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  282 -------------------------------DTRTPQLqSERRLAGHRQEVCGLKWSpDNQYLASGGNDNRLYVWN---- 326
Cdd:PLN00181 615 ktkaniccvqfpsesgrslafgsadhkvyyyDLRNPKL-PLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsms 692

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  327 QHSVN--PVQSYTEHmAAVKAIAWSPHHHGLLASGGGTADRCI------------RFWNTLTGQPMQCVDTGSQVCNLAW 392
Cdd:PLN00181 693 ISGINetPLHSFMGH-TNVKNFVGLSVSDGYIATGSETNEVFVyhkafpmpvlsyKFKTIDPVSGLEVDDASQFISSVCW 771

                        250
                 ....*....|....*....
gi 24639729  393 SKHSSELVSTHGYSQNQIL 411
Cdd:PLN00181 772 RGQSSTLVAANSTGNIKIL 790
WD40 pfam00400
WD domain, G-beta repeat;
419-456 8.12e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 8.12e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24639729   419 TQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWN 456
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 331-371 1.49e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.49e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24639729    331 NPVQSYTEHMAAVKAIAWSPHHHgLLASGGgtADRCIRFWN 371
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 202-326 2.51e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639729  202 SQVTRLCDLSPDANTVtSVSWNERGntvavGTHHGYVTVWDVAANKQINKLNGHSARVGALAWN---SDILSSGSRDR-- 276
Cdd:PTZ00420  26 SRVIDSCGIACSSGFV-AVPWEVEG-----GGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNpcfSEILASGSEDLti 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24639729  277 --WIIQ------RDTRTPQLQserrLAGHRQEVCGLKWSPDNQY-LASGGNDNRLYVWN 326
Cdd:PTZ00420 100 rvWEIPhndesvKEIKDPQCI----LKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 206-267 4.27e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24639729   206 RLCDLSPDAN--TVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSD 267
Cdd:pfam12894  28 RVWTLSPDKEdlEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 292-349 6.25e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 6.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24639729   292 RRLAGHR----------QEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWS 349
Cdd:pfam12894  22 HRLNWQRvwtlspdkedLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH