U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kar karmoisin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45883, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
karprovided by FlyBase
Official Full Name
karmoisinprovided by FlyBase
Primary source
FLYBASE:FBgn0001296
Locus tag
Dmel_CG12286
See related
AllianceGenome:FB:FBgn0001296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12286; Dmel\CG12286
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in aromatic amino acid transport. Predicted to be located in plasma membrane. Is expressed in several structures, including adult fat body; adult head; amnioserosa; somatic precursor cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A10 (solute carrier family 16 member 10) and SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kar in Genome Data Viewer
Location:
87C5-87C5; 3-52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12682186..12689367, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8507908..8515089, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene members only Neighboring gene Cytochrome P450 313a4 Neighboring gene Suppressor of fused Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Position Effects and Variegation Enhancers in an Autosomal Region of DROSOPHILA MELANOGASTER. Henikoff S. Genetics, 1979 Sep. PMID 17248959, Free PMC Article
  2. Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study. Gupta MK, et al. Genetica, 2020 Dec. PMID 32804315
  3. Subcellular localization of the first three enzymes of the ommochrome synthetic pathway in Drosophila melanogaster. Sullivan DT, et al. J Exp Zool, 1974 May. PMID 4133038
  4. A gene responsible for a cuticular hydrocarbon polymorphism in Drosophila melanogaster. Coyne JA, et al. Genet Res, 1999 Jun. PMID 10425916
  5. The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment. Pham A, et al. Genetics, 1995 Jun. PMID 7498739, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aromatic amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
karmoisin
Names
CG12286-PA
CG12286-PB
kar-PA
kar-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12682186..12689367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143768.3 → NP_652025.2  karmoisin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652025.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SN6, Q9VG39
    Related
    FBpp0082135
    Conserved Domains (2) summary
    cd06174
    Location:81 → 459
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:124 → 439
    MFS_1; Major Facilitator Superfamily

  2. NM_001202284.1 → NP_001189213.1  karmoisin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189213.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV48, Q95SN6
    Conserved Domains (2) summary
    cd06174
    Location:81 → 459
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:124 → 439
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C8VV48 C8VV48
Q95SN6 Q95SN6
Q9VG39 Q9VG39

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous