|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
80-474 |
0e+00 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 563.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGG 159
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 160 VLSAGGLLLSSFCTEnIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSY 239
Cdd:cd17420 81 AVSFGGLLLSSFCSS-IGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 240 GLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGR----SRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFV 315
Cdd:cd17420 160 GLEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRrtlhSRINLFLRKIFNVEIFKRKRYVIWALGIPLALFGYFV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 316 PYVHMMQFVKT-TFPGEDVNLPVMCIGITSGIGRLIFGVIADM-PGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFT 393
Cdd:cd17420 240 PYVHLMKFVKEeFFPGKDVNVPLMCIGITSGIGRLIFGVIADMpPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVC 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 394 LVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLI 473
Cdd:cd17420 320 LVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
|
.
gi 320542679 474 K 474
Cdd:cd17420 400 P 400
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
81-459 |
1.77e-107 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 329.06 E-value: 1.77e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17464 82 VGFVGLLASSFVS-SIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRInLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHM 320
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRKFKC-PPLKKIFNFNIWKSTGYRIWAFGIPAALFGYFVPYVHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 321 MQFVKTTFpGEDVNLPV--MCIGITSGIGRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMG 397
Cdd:cd17464 240 MNHVKERF-GEDVNKEVllMCIGITSGIGRLIFGRVADyIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMG 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320542679 398 LFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17464 319 LFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLA 380
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
81-459 |
1.59e-89 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 281.69 E-value: 1.59e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFcTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17465 82 VAFIGLLSSSF-TKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMSLVSAFIILCSFVYkplhpppeppkkkpgrsrinlflrsiinvEIWKRKRFVIWALCVPLALFGYFVPYVHM 320
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLSLTY-----------------------------KVFRRKTYRIWAFGIATAVLGYFVPYVHL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 321 MQFVKTTFP--GEDVNLPVmCIGITSGIGRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMG 397
Cdd:cd17465 212 MKYVEEEFKenKREWVLLV-CIGASSGIGRLMSGKIGDlIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320542679 398 LFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17465 291 LCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLA 352
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
80-459 |
1.83e-77 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 250.16 E-value: 1.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVihsLLTDRLTKLGdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGG 159
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGV---LFVELLEEFG--ESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 160 VLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSY 239
Cdd:cd17352 76 LLAALGLLLSSFAT-SLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 240 GLEGTLRIMSLVSAFIILCSFVYkplhpppeppkkkpgrsrinlflrsiinvEIWKRKRFVIWALCVPLALFGYFVPYVH 319
Cdd:cd17352 155 GWRGALLILGGLCLNLCVCGLLL-----------------------------RLLKDPTFVLLALGVSFAMLGFFVPFVY 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 320 MMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGL 398
Cdd:cd17352 206 LPSYAKSLgIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGF 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320542679 399 FDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17352 286 CSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFC 346
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
81-459 |
2.31e-38 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 145.61 E-value: 2.31e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTklgdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFE-----ESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFCTEnIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17423 77 LSSLGFLLASFATS-LLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINLFlrsiinvEIWKRKRFVIWALCVPLALFGYFVPYVHM 320
Cdd:cd17423 156 WRGALLLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAFGL-------SLLTHRAFLRYALATTLINTGYFIPYVHL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 321 MQFVKTTFPGE-DVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLF 399
Cdd:cd17423 229 VAHARALGLGEyQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFC 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 400 DGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17423 309 AGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVA 368
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
81-459 |
2.81e-37 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 142.26 E-value: 2.81e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVihsLLTDRLTKLGdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGV---LYPEWLDAFG--EGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFcTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17428 77 MVAGGLMLSAF-APNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMSLVSAFIILCSfvykplhpppeppkkkpgrSRINLFlrsiinveiwkrKRFVIWALCVPLALF--GYFVPYV 318
Cdd:cd17428 156 LDGCLLIVGALALNLLACG-------------------SLMRLF------------KNRVFSALFIAILLFdiGAFPPSL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 319 HMMQFVKT-TFPGEDVNLPVMCI-GITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVM 396
Cdd:cd17428 205 LMEDVARSeNIIEEIALIPLVSIiGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAIL 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320542679 397 GLFDGCFiSLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17428 285 GFLSGNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFS 346
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
73-459 |
1.08e-33 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 134.10 E-value: 1.08e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 73 PPDGGArAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKlgdpeASSKAALIGALAIGTTFLFSTMAGCLTDKIGLR 152
Cdd:TIGR00892 11 PPDGGW-GWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQA-----TYSETAWISSIMLAVLYAGGPISSILVNRFGCR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 153 LTTFAGGVLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCL 232
Cdd:TIGR00892 85 PVVIAGGLLASLGMILASFSS-NVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 233 DKLLGSYGLEGTLRIMSLVSAFIILCSFV-------YKPLHPPPEPPKKKPGRSR----------INLFLrsiiNVEIWK 295
Cdd:TIGR00892 164 QYLFESFGWRGSFLILGGLLLHCCVCGALmrpvgpsQRVSKSKSKEGLPPDGSTKklskkstaekINRFL----DFSLFT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 296 RKRFVIWALCVPLALFGYFVPYVHMMQFVK-TTFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGV--NRMYLQQLSLVS 372
Cdd:TIGR00892 240 HRGFLVYLSGNVIMFLGFFAPIIFLVPYAKdKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIrpHVQYLFSFALLF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 373 IGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSY 452
Cdd:TIGR00892 320 NGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNY 399
|
....*..
gi 320542679 453 TLPLILA 459
Cdd:TIGR00892 400 KYIFYAS 406
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
80-459 |
4.91e-29 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 118.77 E-value: 4.91e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKlgdpeASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGG 159
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGG-----SSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 160 VLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVfTVILPPCLDKLLGSY 239
Cdd:cd17421 76 FLVSAGFLISIFAT-SVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 240 GLEGTLRIMSLVSAFIILCSfvykplhpppeppkkkpgrsrinLFLRSIiNVEIWKRKRFVIWALCVPLALFGYFVPYVH 319
Cdd:cd17421 154 DWQGALLIFGGIMLNLVASG-----------------------MLLRPI-DFSLLKDPFFCIYTWSFVFSQLAYFIPYFH 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 320 MMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGL 398
Cdd:cd17421 210 LVARARTLgIDPMDASFIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAI 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320542679 399 FDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17421 290 FCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLA 350
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
80-452 |
5.36e-29 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 118.40 E-value: 5.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTklgdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGG 159
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQ-----QSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 160 VLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSY 239
Cdd:cd17429 76 ILTSLGWVLSAYAT-NVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 240 GLEGTLRIMSLVSAFIILCSfvykplhpppeppkkkpgrSRINLFLRSIINVeiwkrkrFVIWALcvpLALFGYFVPYVH 319
Cdd:cd17429 155 GWRNAMFIQGAVSLNLCVCG-------------------ALMRLFTNKVFVA-------FIFWAL---FAYCSFVIPFIH 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 320 MMQFVKT-TFPGEDVNLPVMC-IGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMG 397
Cdd:cd17429 206 LPEIVKLyGLSEQNDKFPLTSiIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIG 285
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 320542679 398 LFDGCFiSLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSY 452
Cdd:cd17429 286 FSSGYF-SLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKY 339
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
122-459 |
8.73e-28 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 114.91 E-value: 8.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 122 SKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAI 201
Cdd:cd17424 38 ARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFAT-SLEYLYLTLGVLTGLGFALCYSPAIAM 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 202 LGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSfvykplhpppeppkkkpgrsri 281
Cdd:cd17424 117 VGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCG---------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 282 nLFLRSIInveiwkRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVNLPVMCI-GITSGIGRLIFGVIADMPGV 360
Cdd:cd17424 175 -ALMRFLL------MPDFLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSIlGVIDIIGNITFGWLTDRRCL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 361 N--RMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVG 438
Cdd:cd17424 248 KkyRYFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVS 327
|
330 340
....*....|....*....|.
gi 320542679 439 PPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17424 328 PPIAGWLVDTTGTYTAAFLLS 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
78-459 |
2.24e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 114.59 E-value: 2.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 78 ARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLtKLGDPEASskaaLIGALAIGTTFLFSTMAGCLTDKIGLRLTTFA 157
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQLG----LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 158 GGVLSAGGLLLSSFCTEniGALYFTYGIMFGLGAALAYTPTLAILGHYF-KRYLGKVSGFVTAGSSVFTVILPPCLDKLL 236
Cdd:COG2223 76 GLLLLGIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 237 GSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINlflrsiinvEIWKRKRFviWALCvpLALFGYFVP 316
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQL---------EALRDPRF--WLLS--LLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 317 YV----HMMQFVKTTFPGEDVN--LPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILV 390
Cdd:COG2223 221 FIgfssWLPPYLVDQFGLSAATagLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLV 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320542679 391 SFtLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:COG2223 301 LF-LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
81-452 |
1.64e-26 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 111.38 E-value: 1.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTklgdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFN-----ETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFcTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17422 77 LISLGMITASF-ASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMSLVSAFIILCSFVykplhpppeppkkkpgrsrinlflrsiinVEIWKRKRFVIWALCVPLALFGYFVPYVHM 320
Cdd:cd17422 156 WRYCLLVVGALQLNIVVCGAL-----------------------------LRVLKEPGFICYALFGLFATLGFFAPQLYI 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 321 MQFVKTTFPGEDVN---LPVMciGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMG 397
Cdd:cd17422 207 IPLSLSLGIDQDWAaymLSAM--AIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYG 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 320542679 398 LFDGCFISLLGPIAYE--ICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSY 452
Cdd:cd17422 285 FMFGTVAGTHIPLLAEddVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNY 341
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
79-459 |
7.09e-26 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 110.01 E-value: 7.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 79 RAWLVMVSAFLCNGIIfGFINTYgvihSLLTDRLTKLGDPEASSkAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAG 158
Cdd:cd17353 1 RRWLVLLGAVLMHLIL-GYQYAW----SVFNPPLSSALGWSLAS-VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 159 GVLSAGGLLLSSFcTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGS 238
Cdd:cd17353 75 GILFGLGFILSAF-AISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 239 YGLEGTLRIMSLVSA-FIILCSFVYKPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRF-VIW-----ALCVPLALF 311
Cdd:cd17353 154 VGVPTTFLILGIIFLiIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFwLLWlmfflNATAGLMLI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 312 GYFVPYVHmmqfvktTFPGEDVNLPVMCIGITS---GIGRLIFGVIADMPGvnRMYLQQLSLVSIGLVTLLLPLTNS-YV 387
Cdd:cd17353 234 GQAKPIGQ-------EFAGLDAGIAALAVSILSifnGGGRPFWGWLSDKIG--RKNTLSIAFLIQGVAMFLLPFIGSvAV 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320542679 388 ILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLL---GLSSIpltVGPPVAGMiFDSTNSYTLPLILA 459
Cdd:cd17353 305 LFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYtakGVGGL---IGPIIAAY-VLYTGGYNAAFIIA 375
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
80-459 |
2.14e-25 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 108.28 E-value: 2.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVIHSLLTdRLTKLGDPEASSKAALIGALAIGTTFLFSTMagclTDKIGLRLTTFAGG 159
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELM-REFGVGYSDTAWISSILLAMLYGTGPLCSIL----VNRFGCRPVMLVGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 160 VLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSY 239
Cdd:cd17430 76 LLASLGMILASFCT-SIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 240 GLEGTLRIMSLVSAFIILCSFVykplhpppeppkkkpgrsrinlfLRSiINVEIWKRKRFVIWALCVPLALFGYFVPYVH 319
Cdd:cd17430 155 GWRGGFLILGGLLLNCCTCGAV-----------------------MRP-LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIF 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 320 MMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNR--MYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVM 396
Cdd:cd17430 211 VVNYAKDIgVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPrvVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFF 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320542679 397 GLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17430 291 GISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLA 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
77-459 |
2.98e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.79 E-value: 2.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 77 GARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLtKLGDPEASskaaLIGALAIGTTFLFSTMAGCLTDKIGLRLTTF 156
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQLG----LLASAFFLGYALGQIPAGLLADRFGRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 157 AGGVLSAGGLLLSSFCTeNIGALYFTYgIMFGLGAALAYTPTLAILGHYF-KRYLGKVSGFVTAGSSVFTVILPPCLDKL 235
Cdd:COG2271 80 IGLLLWGLATLLFGFAT-SFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 236 LGSYGLEGTLRIMSLVSAFIILCSFVYKplhpppeppkkkpgrsrinlflrsiinveiwkrkrFVIWALCVplalFGYFV 315
Cdd:COG2271 158 LAAFGWRAAFLILGLPGLLLALLRFWLL-----------------------------------ALAYFLVY----FALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 316 PYVHMMQFVKTT--FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFT 393
Cdd:COG2271 199 FLTWLPTYLVEVrgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALL 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320542679 394 LVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTnSYTLPLILA 459
Cdd:COG2271 279 FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLL 343
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
81-452 |
1.55e-20 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 94.02 E-value: 1.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTklgdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFG-----YSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFcTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17314 77 MVLAGYTYLSY-VFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMSLVSAFIILC-SFVYKPLHPPPEPPKKKPGRSRINLflrsiinVEIWKRKRFVIWALCVPLALFGYF----- 314
Cdd:cd17314 156 LALVYTILGILAAIVLSVvSLLGFKEPPDNQARLHVQKKKTQTM-------GEIFRDKVFWILFIAIFLVLIGGFlfian 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 315 -VPYVHMMQFVKTTFpgedVNLPVMCIGITSGIGRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSF 392
Cdd:cd17314 229 mASLVRSLQLDAPSF----VTKLMSIYGLFNAFGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLT 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 393 TLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSY 452
Cdd:cd17314 305 GSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSY 364
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
80-454 |
2.53e-20 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 92.91 E-value: 2.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLtKLGDPEASSKAALIGALAIGTTFLFSTmagcLTDKIGLRLTTFAGG 159
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEF-QASNSETSWFPSIMTAVLHAGGPLCSI----LVERFGCRVTVMLGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 160 VLSAGGLLLSSFCtENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSY 239
Cdd:cd17425 76 LLSGVGMVASSFS-HSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 240 GLEGTLRIMSLVSAFIILCSFVykplhpppeppkkkpgrsrinlfLRSIINveiwkRKRFVIWALCVPLALFGYFVPYVH 319
Cdd:cd17425 155 GWRGSFLVFGGVLLNCCVCGAV-----------------------MRPFCS-----NTRYQIYTLGVTWMVLGFVLPLIY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 320 MMQFvkTTFPGEDVNLPVMCIGITSGIG---RLIFGVIADMPGVN--RMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTL 394
Cdd:cd17425 207 LVPY--ATSNGMDESKAALLLSILGFINifmRPLAGLLSGLPVFKgrRIYLFSLALLLNGLSNLICAISASFPVLLVYCL 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 395 VMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTL 454
Cdd:cd17425 285 LYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSY 344
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
81-452 |
3.67e-20 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 92.63 E-value: 3.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKlgdpeASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNA-----TSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17426 77 LSGAGLIAASFCN-TVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTLRIMslvSAFIILCSfvykplhpppeppkkKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHM 320
Cdd:cd17426 156 WRGSFLIL---GGLLLNCC---------------VAGSLMRPIGPKPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 321 MQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNR--MYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMG 397
Cdd:cd17426 218 SNYAKSKqISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPriQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFG 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 320542679 398 LFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSY 452
Cdd:cd17426 298 FAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDY 352
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
81-452 |
6.69e-18 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 85.63 E-value: 6.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKlgdpeASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 160
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHT-----SYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 161 LSAGGLLLSSFCTeNIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYG 240
Cdd:cd17427 77 LCSLGMISASFCN-SVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 241 LEGTlrimslvsaFIILCSFVYKPLHPPPeppkkkpgrsrinlFLRSIinVEIWKRKRFVIWALCVPLALFGYFVPYVHM 320
Cdd:cd17427 156 WRGS---------FLILGGLLLNCCVAGS--------------LMRPL--GPLFKHRGFLIYLSGNVIMFLGFFAPIVFL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 321 MQFVKTTFPGEDVNLPVMCI-GITSGIGRLIFGVIADMPGVNR--MYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMG 397
Cdd:cd17427 211 APYAKHMGIDEYSAAFLLSIlAFVDMFARPSMGLVANSKWIRPriQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFG 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 320542679 398 LFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSY 452
Cdd:cd17427 291 FAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNY 345
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
80-459 |
9.19e-18 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 85.40 E-value: 9.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 80 AWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLtklgdpeASSKAALIGALAIGTTF--LFSTMAGCLTDKIGLRLTTFA 157
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEF-------GWSRAVISLAFTVGLLAfgLAQPFVGRLLDRFGPRRVMLL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 158 GGVLSAGGLLLSSFCTeNIGALYFTYGIMFGLGAA-LAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLL 236
Cdd:cd17355 74 GLLLLAAGLVLLALAT-SLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 237 GSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINL--FLRsiinvEIWKRKRFviWALCVPLALFGYF 314
Cdd:cd17355 153 EAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPgsTLK-----EALRSASF--WLLALAFFLCGFA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 315 V--PYVHMMQFVKT-TFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLpLTNSYVILVS 391
Cdd:cd17355 226 VvgLIVHLVPYLADrGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLL-LPFPPLALLL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320542679 392 FTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17355 305 FAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALA 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
124-458 |
1.60e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.92 E-value: 1.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 124 AALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFcTENIGALYFTYGIMfGLGAALAYTPTLAILG 203
Cdd:COG2807 55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-APSVALLLAGTALI-GAGIAVGNVLLPGLIK 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 204 HYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRinl 283
Cdd:COG2807 133 RWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR--- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 284 flrsiinvEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADmpgvnR 362
Cdd:COG2807 210 --------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAgLSAATAGLLLSLFQLAGIPGSLLVPLLAD-----R 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 363 MYLQQLSLVSIGLVT-------LLLPLTNSYVILVSFTLVMG-LFDGC--FISLLGPIAYEICGPSGATQAIGFLLGLss 432
Cdd:COG2807 277 LGDRRPLLLLLGLLGlagllglLLAPGSLPWLWAVLLGLGQGgLFPLAltLIGLRARTPAEAAALSGMAQSVGYLLAA-- 354
|
330 340
....*....|....*....|....*.
gi 320542679 433 ipltVGPPVAGMIFDSTNSYTLPLIL 458
Cdd:COG2807 355 ----LGPLLVGALHDATGSWTAALLL 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
124-439 |
7.28e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.47 E-value: 7.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 124 AALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTeNIGALYFTyGIMFGLGAALAYTPTLAILG 203
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS-SLWLLLVL-RVLQGLGAGALFPAALALIA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 204 HYF-KRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRIN 282
Cdd:pfam07690 112 DWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 283 LFLRsiinvEIWKRKRFVIWALCVpLALFGYFVPYVHMMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVN 361
Cdd:pfam07690 192 VAWK-----ALLRDPVLWLLLALL-LFGFAFFGLLTYLPLYQEVLgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320542679 362 RMYLQQLSLVSIGLVTL-LLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGP 439
Cdd:pfam07690 266 RRLLLALLLLILAALGLlLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
100-459 |
5.18e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 5.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 100 TYGVIHSLLTDRLTKLGDPEasSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTenIGAL 179
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSA--SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 180 YFTYGIMFGLGAALAYTPTLAILGHYFK-RYLGKVSGFVTAGSSVFTVILPpcldkLLGSY---GLEGTLRIMSLVSAFI 255
Cdd:cd06174 87 LLLGRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGP-----LLGGIlasSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 256 ILCSFVYKPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVNL 335
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 336 PVM--CIGITSGIGRLIFGVIADMPGvNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYE 413
Cdd:cd06174 242 GLLlsLFGLAGALGSLLLGLLSDRLI-GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 320542679 414 ICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
74-433 |
7.47e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.25 E-value: 7.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 74 PDGGARAWLVMVSAFLCNGIIFGfinTYGVIHSLLTDRLTKLGDPEASskAALIGALAIGTTFLFSTMAGCLTDKIGLRL 153
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGL---GIGIVLPALPLIAADLGASPAQ--AGLVVTAYLLGAALGAPLAGRLADRFGRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 154 TTFAGGVLSAGGLLLSSFCTeNIGALYFTYGIMfGLGAALAYTPTLAILGHYF-KRYLGKVSGFVTAGSSVFTVILPPCL 232
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAP-SLWLLLAARFLQ-GLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 233 DKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEppkkkpgRSRINLFLRsiinvEIWKRKRFVIWALCVPLALFG 312
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA-------RARLRGSLR-----ELLRRPRLLLLLLLAFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 313 YFVPYVHMMQFVKTTF--PGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLqqLSLVSIGLVTLLLPLTNSYVILV 390
Cdd:COG2814 223 FFALFTYLPLYLQEVLglSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWLLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 320542679 391 SFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSI 433
Cdd:COG2814 301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
93-459 |
1.09e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.08 E-value: 1.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 93 IIFGFINTYGVIHSLLTDRLTKLGdpeASSKAA--LIGALAIGTTfLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSS 170
Cdd:cd17325 4 ALFLDMLGYGIIIPILPLYAESLG---ASVAQIglIVAAYALAQL-LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 171 FCTeNIGALYFTYgIMFGLGAALAYTPTLAILGHYF-KRYLGKVSGFVTAGSSVFTVILPPcldklLGSYGLEGT-LRIM 248
Cdd:cd17325 80 FAT-SYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPL-----LGGLLADALgYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 249 SLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPY--VHMMQFVKt 326
Cdd:cd17325 153 FLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFlpLYAAELGG- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 327 tFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLqqLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISL 406
Cdd:cd17325 232 -LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL--IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 320542679 407 LGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDsTNSYTLPLILA 459
Cdd:cd17325 309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAA 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
79-459 |
5.37e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.33 E-value: 5.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 79 RAWLVMVSAFLCNGIIFGFINtygvihSLLTDRLTKLGDPEASSkAALIGALAIGTtFLFSTMAGCLTDKIGLRLTTFAG 158
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWG------PLIPALKDAFGLSDAQA-GLLLFAFFLGY-LLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 159 GVLSAGGLLLSSFcTENIGALYFTYgIMFGLGAAL---AYTPTLAILGH-YFKRYLGKVSGFVTAGSSVFTVILppcldK 234
Cdd:COG0738 80 LLLMALGLLLFAL-APSYPLLLLAL-FLLGLGLGLldvAANPYVAALGPeTAASRLNLLHAFFSLGALLGPLLG-----G 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 235 LLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINLFLRSiinveIWKRKRFVIWALCVPLALFGYF 314
Cdd:COG0738 153 LLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKS-----LLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 315 VPYVHMMQFVKTTFpGEDVNLPVMCIGITSG---IGRLIFGVIADMPGVNRMyLQQLSLVSIGLVTLLLPLTNSYVILVS 391
Cdd:COG0738 228 AIGDWLPLYLKDVL-GLSEATAALGLSLFWGgmtIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLALLAPGPWLALIG 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320542679 392 FTLVmglfdGCFISLLGPIAYEI---CGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTN---SYTLPLILA 459
Cdd:COG0738 306 LALV-----GLGLSLMFPTIFSLaldGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGlraAFLVPLVCY 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
126-458 |
3.98e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.71 E-value: 3.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 126 LIGALAIGTTFlFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFctenIGALYFTYGIMFGLGAALAYTP---TLAIL 202
Cdd:cd17475 36 LLSALNLGVAV-SMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL----VGSYPVLLVLLFLVGAGYGSVQpggGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 203 GHYFKRYLGKVSGF----VTAGSSVFTVILPPcldkLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGR 278
Cdd:cd17475 111 RWFPPRERGLAMGIrqtgVPLGGALAAALLPP----LALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAST 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 279 SRINLfLRSIINVEIWkRKRFVIWALCVP-LALFGYFVPYVHmmqfvkttfpgEDVNLPVMCIG-------ITSGIGRLI 350
Cdd:cd17475 187 LLRSL-KEVLRNRDVW-LIAIAGALLVAPqFALLTFLLLFLH-----------DHLGLSVVAAGallavaqLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 351 FGVIAD--MPGVNRMYLQQLSLVSIG--LVTLLLPLTNSYVILVSFTLVMGLF----DGCFISLLGpiayEICGPSGATQ 422
Cdd:cd17475 254 LGRVSDrvFGGRRRPVLVITAAIAAAalLVLSLLSPGTPLWLLVLLLILLGLFaigwNGLYLTLVA----ESAGPEQAGT 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 320542679 423 AIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLIL 458
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLA 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
124-459 |
9.24e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 9.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 124 AALIGALAIGTTFLFSTMAGCLTDKIGLR----LTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMfGLGAALAYTPTL 199
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliLADLLRALLAAVLALLALLGSLSLWLLLVLAFLL-GIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 200 AILGHYFKR-YLGKVSGFVTAGSSVFTVILPPcldklLGS--YGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKkkp 276
Cdd:cd06173 115 ALLPELVPKeQLVRANALNSLATQLARIIGPA-----LGGllVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAP--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 277 gRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMM--QFVKTTFPGEDVNLPVM--CIGITSGIGRLIFG 352
Cdd:cd06173 187 -GESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLlpLLAKEVLGGGAAGYGLLlaAFGVGALLGALLLG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 353 VIADMPGVNRMYLqqLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSS 432
Cdd:cd06173 266 RLSKRRRRGRLLL--IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343
|
330 340
....*....|....*....|....*..
gi 320542679 433 IPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd06173 344 GAMPLGALLAGLLADALGLSAVFLLAG 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
342-447 |
1.41e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 342 ITSGIGRLIFGVIADMPGVNRMYLqqLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGAT 421
Cdd:COG2814 56 LGAALGAPLAGRLADRFGRRRVLL--LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRG 133
|
90 100
....*....|....*....|....*.
gi 320542679 422 QAIGFLLGLSSIPLTVGPPVAGMIFD 447
Cdd:COG2814 134 RALGLLGAGLGLGPALGPLLGGLLAD 159
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
124-459 |
5.43e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 5.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 124 AALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTeNIGALYFTYGIM-FGLGAALAYTPTLaIL 202
Cdd:cd17316 38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP-TPILLLVLRFLQgIGIGGEYPGASTY-VA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 203 GHYFKRYLGKVSGFVTAG-------SSVFTVILPPCLDKLLGsyglegtLRIMSLVSAFIILCSFVYkplhpppeppkkk 275
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGwalgallAALVASLLIPLLSGDWG-------WRILFLIGALPALLALLL------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 276 pgrsrinlflrsiinveiwkRKRFVIWALCVPLALFGYFVPYVHMMQFVKTT--FPGEDVNLPVMCIGITSGIGRLIFGV 353
Cdd:cd17316 176 --------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVlgLSPATSSLYLLLISLGALVGALIAGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 354 IADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSI 433
Cdd:cd17316 236 LSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRL 315
|
330 340
....*....|....*....|....*.
gi 320542679 434 PLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17316 316 GGGGAPPLIALLLASTGGTGVPALIL 341
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
79-202 |
6.01e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 79 RAWLVMVSAFLCNGIIFGFINTYGVIhsLLTDRLtklGDPEASskAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAG 158
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLY--YFKYVL---GLSAAL--VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 320542679 159 GVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAIL 202
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAML 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
76-261 |
7.16e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.71 E-value: 7.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 76 GGARAWLVMVSAFLCNGIIFGFInTYGVihSLLTDRLtKLGDPEASSKAALIGALAIGTTFLfstmAGCLTDKIG--LRL 153
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFL-TWLP--TYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLL----GGWLSDRLGrrRKL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 154 TTFAGGVLSAGGLLLSSFCTEniGALYFTYGIMFGLGAALAYTPTLAILGHYF-KRYLGKVSGFVTAGSSVFTVILPPCL 232
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLV 327
|
170 180
....*....|....*....|....*....
gi 320542679 233 DKLLGSYGLEGTLRIMSLVSAFIILCSFV 261
Cdd:COG2271 328 GYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
333-459 |
6.06e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 6.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 333 VNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLqqLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAY 412
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA 111
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 320542679 413 EICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
136-459 |
1.44e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.48 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 136 FLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTeNIGALYFTYgIMFGLGAALAYTPTLAILGHYF-KRYLGKVS 214
Cdd:cd17319 52 ALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT-SLTSLYVLR-FLLGVAEAGFFPGAIKALAEWFpARERGRAT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 215 GFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSafIILCSFVYkplhpppeppkkkpgrsrinLFLRSIinveiW 294
Cdd:cd17319 130 GLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLG--LLLAVLWW--------------------FYLRQV-----W 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 295 KrkrFVIWALCVPLALFG--YFVPyvhmmQFVKTT--FPGEDVNLPVMCIGITSGIGRLIFGVIAD--MPGVNRMYLQQL 368
Cdd:cd17319 183 G---LALGYFGINYALYGllTWLP-----TYLKQArgFSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 369 SLVSIGLVTLLLPLTNSYVILVSFTLVMGLFdGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDS 448
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGFGI-GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDA 333
|
330
....*....|.
gi 320542679 449 TNSYTLPLILA 459
Cdd:cd17319 334 TGSYTAAFLFL 344
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
79-257 |
2.76e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 79 RAWLVMVSAFLCNGIIFGFINTYGVIHSLLtdrltklgdpeaSSKAALIGALAIGTTFLFSTM-AGCLTDKIGLRLTTFA 157
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYLQTVLGL------------SPATSSLYLLLISLGALVGALiAGLLSDRIGRKKTLVI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 158 GGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFK---RYLGkvSGFVTAGSSVFTVILPPCLDK 234
Cdd:cd17316 249 GLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtevRATG--VGLSYNLGRLGGGGAPPLIAL 326
|
170 180
....*....|....*....|...
gi 320542679 235 LLGSYGLEGTLRIMSLVSAFIIL 257
Cdd:cd17316 327 LLASTGGTGVPALILALLAIVAL 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
303-449 |
3.63e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 3.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 303 ALCVPLALFGYFVPYVHMMQFVKttFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLqqLSLVSIGLVTLLLPL 382
Cdd:cd06174 5 FFLTGLARGLISPLLPALLQSFG--LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLL--LGLLLFALGALLFAF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320542679 383 TNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDST 449
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
79-261 |
3.69e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.30 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 79 RAWLVMVSAFLCNGI---IFGFINTYGVihslltdrlTKLGDPEASSKAALigalaigTTFLFSTMAGC-----LTDKIG 150
Cdd:COG0738 211 RLLLGGLAIFLYVGAegaIGDWLPLYLK---------DVLGLSEATAALGL-------SLFWGGMTIGRflggfLLKRFG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 151 LRLTTFAGGVLSAGGLLLSSFCTENIGALYFTygIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPP 230
Cdd:COG0738 275 PVRLLRLSALLAAVGLLLALLAPGPWLALIGL--ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPP 352
|
170 180 190
....*....|....*....|....*....|.
gi 320542679 231 CLDKLLGSYGLEGTLRIMSLVSAFIILCSFV 261
Cdd:COG0738 353 LIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
121-223 |
4.41e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.93 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 121 SSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIG-ALYFTYGIMFGLGAALAYTP-T 198
Cdd:cd17321 203 PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSvWLLLPGLVLLGLGLGLFATPlT 282
|
90 100
....*....|....*....|....*
gi 320542679 199 LAILGHYFKRYLGKVSGFVTAGSSV 223
Cdd:cd17321 283 NAALSSVPKEKAGAASGILNTARQL 307
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
81-227 |
7.02e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.17 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 81 WLVMVSAFLCNGIIFGFINtYGVIHSLLTdrltkLGDPEASSKAALIgALAIGTTfLFSTMAGCLTDKIG-LRLTTFAGG 159
Cdd:cd17502 170 LLSSIFGFLFGGALFGLIY-YLPLYFQLV-----LGDSATKSGVRLL-PLIIGLV-IGSIISGALISKTGrYKPLIVIGT 241
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320542679 160 VL-SAGGLLLSSFCTENIGALYFTYGIMFGLGAALAY-TPTLAILGHYFKRYLGKVSGFV----TAGSSVFTVI 227
Cdd:cd17502 242 ILmSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFqQPLVAVQNAVPPADVGVATATNtffrSLGGTLGVAI 315
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
124-459 |
9.61e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 9.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 124 AALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTenigalyfTYGIMF------GLGAALAYTP 197
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP--------NYWLLLllvalaGIGSAAFHPE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 198 TLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIM--SLVSAFIILCSFVYKPLHPPPEPPKKK 275
Cdd:cd17478 105 GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLiiPGLAVALLLLRLRPLKKPEAKKAAAKS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 276 PGRSRINLFLRSIInveiwkrkRFVIWALCVPLALFGY--FVPYvhmmQFVKTTFPGEDVNLPVMCIGITSGIGRLIFGV 353
Cdd:cd17478 185 SARSTLKGVWRALL--------LLLIIVFLRSWVLSSLttFLPF----YLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 354 IADMPGVNRMYLqqLSLVSIGLVTLLLPLTNSYVILVsFTLVMGLFDGCFISLLGPIAYEIcGPSGATQAIGFLLGLSSI 433
Cdd:cd17478 253 LSDRFGRRRVII--ASLLLAAPFLLLFLLTPGIWSYI-LLVLAGFLLFASFPVTVVLAQEL-LPGNVGLASGLMMGLSFG 328
|
330 340
....*....|....*....|....*.
gi 320542679 434 PLTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17478 329 LGGIGAPVLGALADAFGLESVLLILA 354
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
358-459 |
1.02e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 41.87 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 358 PGVNRMYLQQL------SLVSIGLVTLLL--PLTNSYVILVSF----TLVMGLfdgCFISLLGPIAYEICGPSGATQAIG 425
Cdd:cd17409 254 PVLARMKDQRLlavlvsLLGAVGLIGLLLapSLAILWVILFGFgsgaGFILGL---AFIGLRTSSAHQAAALSGMAQCVG 330
|
90 100 110
....*....|....*....|....*....|....
gi 320542679 426 FLLGlssiplTVGPPVAGMIFDSTNSYTLPLILA 459
Cdd:cd17409 331 YLLA------ATGPMLVGALHDLTGSWSVPLLLC 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
137-227 |
3.57e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 137 LFSTMAGCLTDKIGLRLTTFAGGVLSA-GGllLSSFCTENIGALYFTYGImFGLGAALAYTPTLAILGHYF-----KRYL 210
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGiGG--VAGLFLDSLYALLASRAL-LGIGVAGIMTLATALIGDYFegeerAKML 126
|
90
....*....|....*..
gi 320542679 211 GKVSGFVTAGSSVFTVI 227
Cdd:cd17473 127 GLQSAAMSLGGVVFLLL 143
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
79-202 |
3.63e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 79 RAWLVMVSAFLCNGIIFGFINTYGVIHslLTDRLtkLGDPEASSKAALIGALAIGTTFLFStmagCLTDKIGLRLTTFAG 158
Cdd:cd17332 221 RPFLILLLAYLLYFLAFNIVNTVLVYY--FKYVL--GGRAELVLLLLLILSGALLALLPWP----PLKKRFGKKKAFFIG 292
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 320542679 159 GVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAIL 202
Cdd:cd17332 293 LLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAML 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
93-459 |
4.29e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 4.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 93 IIFGFINTYGVIHSLLTDRLTKLGdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFC 172
Cdd:cd17489 4 ANFFFFLSFYLLLPVLPLYAHDLG--GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 173 TENIG--ALYFTYGIMFGLGAALAYTPTLAILGhyfKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLegtlRIMSL 250
Cdd:cd17489 82 TSVALllVLRLIHGIGWGAFTTAAATLVADIIP---PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF----AVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 251 VSAFIILCSFVyKPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRkrfviwALCVPLALFGY-----FVPyVHMMQFvk 325
Cdd:cd17489 155 VAAVLALLALL-LVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPP------ALILFLASIAYgaistFLP-LYAAER-- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 326 ttfPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVtLLLPLTNSYVILVSFtLVMGLFDGCFIS 405
Cdd:cd17489 225 ---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLL-LLSFAGSPWMLLLAA-VLYGLGFGLLFP 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 320542679 406 LLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTnSYTLPLILA 459
Cdd:cd17489 300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLA 352
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
116-404 |
4.67e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 40.29 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 116 GDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTEnIGALYFTYGIMFGLGAALA- 194
Cdd:PRK08633 41 DGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYY-LGWFWLAFAVTFLLGAQSAi 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 195 YTPT-----LAILGhyfKRYLGKVSGFV------------TAGSSVFTVILPPCLDKLLGSYGLEGtlrimslvsAFIIL 257
Cdd:PRK08633 120 YSPAkygiiPELVG---KENLSRANGLLeaftivailagtALFSFLFESVNGNTPSEILGRIAPAG---------LVLLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 258 CSFVYKPLHPPPEPPKKkpgrSRINLFLRSIIN--VEIWK-----RKRFVIWALCVPLALFgYFVPyvhmmQFVKTTFP- 329
Cdd:PRK08633 188 VAVLGLIFAYRLPKVPA----AAPEVFDKKKYLfpKLLWRnlkllRSDRVLWLAIIGLSYF-WFIS-----QLAQANFPa 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 330 ------GED----VNLPVMCIGITSGIGRLIFGviadmpGVNRMYLqQLSLVSIG-----LVTLLLPLTNSyVILVSFTL 394
Cdd:PRK08633 258 yakevlGLDntfqVQYLLAASAIGIGIGSLLAG------RLSGRHI-ELGLVPLGalglaLSLFLLPTAPS-LASVLVLF 329
|
330
....*....|.
gi 320542679 395 V-MGLFDGCFI 404
Cdd:PRK08633 330 FlFGFSAGLFI 340
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
73-229 |
7.92e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.64 E-value: 7.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542679 73 PPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTklgdpEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLR 152
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLG-----ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320542679 153 LTTFAGGVLSAGGLLLSSFCTeNIGALYFTYGIMfGLGAALAYTPTLAILGHYF-KRYLGKVSGFVTAGSSVFTVILP 229
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAP-SPELLIAARALQ-GIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGP 155
|
|
| |
