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bon bonus [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44235, updated on 9-Dec-2024

Summary

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Official Symbol
bonprovided by FlyBase
Official Full Name
bonusprovided by FlyBase
Primary source
FLYBASE:FBgn0023097
Locus tag
Dmel_CG5206
See related
AllianceGenome:FB:FBgn0023097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0241/08; 0249/12; 0434/20; 0487/06; 150268_at; 150269_at; anon-WO0118547.418; Bon; Bonus; CG15687; CG5206; Dmel\CG5206; l(3)S043420
Summary
Enables chromatin binding activity. Involved in chromatin organization and epidermal cell fate specification. Located in chromatin and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; ganglia; larval external muscle cell; multidendritic neurons; and neuron projection bundle. Orthologous to several human genes including TRIM24 (tripartite motif containing 24). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See bon in Genome Data Viewer
Location:
92F2-92F3; 3-69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20593139..20612540)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16418861..16438262)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46044 Neighboring gene Septin 2 Neighboring gene Signal recognition particle 72 Neighboring gene Pseudouridine synthase 1 Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hairless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of p53: TRIM24 enters the RING. Jain AK, et al. Cell Cycle, 2009 Nov 15. PMID 19844164
  2. Rapid phenotypic analysis of uncoated Drosophila samples with low-vacuum scanning electron microscopy. Tardi NJ, et al. Fly (Austin), 2012 Jul-Sep. PMID 22722327
  3. Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism. Ito H, et al. Cell, 2012 Jun 8. PMID 22682252
  4. Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. Beckstead RB, et al. Genetics, 2005 Feb. PMID 15545640, Free PMC Article
  5. Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute. Jasti N, et al. Dev Genes Evol, 2020 Jul. PMID 32623522

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes.
    Title: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes.
  2. Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries.
    Title: Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries.
  3. Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.
    Title: Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.
  4. Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them.
    Title: Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
  5. TRIM24 homolog, bonus, targets endogenous p53 for degradation.
    Title: Trim24 targets endogenous p53 for degradation.
  6. bon is a chromatin-associated protein that acts as a modifier of position-effect variegation.
    Title: Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 20601970-20602409 mobile_element_type = transposon:INE-1{}6205

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bonus
Names
CG5206-PA
CG5206-PB
CG5206-PC
CG5206-PD
CG5206-PE
CG5206-PF
bon-PA
bon-PB
bon-PC
bon-PD
bon-PE
bon-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20593139..20612540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079985.4 → NP_524724.2  bonus, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524724.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3Y7, Q9VDK5
    Related
    FBpp0083320
    Conserved Domains (5) summary
    cd05502
    Location:963 → 1072
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:284 → 409
    BBC; B-Box C-terminal domain
    cd00021
    Location:239 → 275
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15541
    Location:899 → 943
    PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
    pfam14634
    Location:82 → 130
    zf-RING_5; zinc-RING finger domain

  2. NM_001275836.1 → NP_001262765.1  bonus, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262765.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGE5, Q9U3Y7
    Conserved Domains (5) summary
    cd05502
    Location:963 → 1072
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:284 → 409
    BBC; B-Box C-terminal domain
    cd00021
    Location:239 → 275
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15541
    Location:899 → 943
    PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
    pfam14634
    Location:82 → 130
    zf-RING_5; zinc-RING finger domain

  3. NM_001275838.1 → NP_001262767.1  bonus, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262767.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHT0, Q9U3Y7
    Conserved Domains (5) summary
    cd05502
    Location:955 → 1064
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:284 → 409
    BBC; B-Box C-terminal domain
    cd00021
    Location:239 → 275
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15541
    Location:891 → 935
    PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
    pfam14634
    Location:82 → 130
    zf-RING_5; zinc-RING finger domain

  4. NM_001275837.1 → NP_001262766.1  bonus, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262766.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH12, Q9U3Y7
    Conserved Domains (5) summary
    cd05502
    Location:949 → 1058
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:284 → 409
    BBC; B-Box C-terminal domain
    cd00021
    Location:239 → 275
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15541
    Location:885 → 929
    PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
    pfam14634
    Location:82 → 130
    zf-RING_5; zinc-RING finger domain

  5. NM_001275839.1 → NP_001262768.1  bonus, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262768.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHG7, Q9U3Y7
    Conserved Domains (5) summary
    cd05502
    Location:953 → 1061
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:284 → 409
    BBC; B-Box C-terminal domain
    cd00021
    Location:239 → 275
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15541
    Location:889 → 933
    PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
    pfam14634
    Location:82 → 130
    zf-RING_5; zinc-RING finger domain

  6. NM_001170194.2 → NP_001163665.1  bonus, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163665.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHL4, Q9U3Y7
    Conserved Domains (5) summary
    cd05502
    Location:955 → 1064
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:284 → 409
    BBC; B-Box C-terminal domain
    cd00021
    Location:239 → 275
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15541
    Location:891 → 935
    PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
    pfam14634
    Location:82 → 130
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGE5 A0A0B4KGE5
A0A0B4KH12 A0A0B4KH12
A0A0B4KHG7 A0A0B4KHG7
A0A0B4KHT0 A0A0B4KHT0
A8WHL4 A8WHL4
Q9U3Y7 Q9U3Y7
Q9VDK5 Q9VDK5

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