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Brd8 Bromodomain containing 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43460, updated on 9-Dec-2024

Summary

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Official Symbol
Brd8provided by FlyBase
Official Full Name
Bromodomain containing 8provided by FlyBase
Primary source
FLYBASE:FBgn0039654
Locus tag
Dmel_CG14514
See related
AllianceGenome:FB:FBgn0039654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14514; dBrd8; Dmel\CG14514
Summary
Involved in DNA repair-dependent chromatin remodeling and negative regulation of gene expression. Part of NuA4 histone acetyltransferase complex. Is expressed in spermatozoon. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Brd8 in Genome Data Viewer
Location:
99A1-99A1; 3-98 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29223485..29226276)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25049207..25051998)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin specific protease 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional cofactors display specificity for distinct types of core promoters. Haberle V, et al. Nature, 2019 Jun. PMID 31092928, Free PMC Article
  2. Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. Rust K, et al. EMBO J, 2018 Aug 15. PMID 29997178, Free PMC Article
  3. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529
  4. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Lu J, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517653, Free PMC Article
  5. Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity. Bailetti AA, et al. Dis Model Mech, 2019 May 30. PMID 31072879, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bromodomain containing 8
Names
Brd8-PA
CG14514-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29223485..29226276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143428.4 → NP_651685.2  bromodomain containing 8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651685.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9B8, Q9VAM5
    Related
    FBpp0084763
    Conserved Domains (3) summary
    cd05507
    Location:729 → 833
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    PHA03249
    Location:402 → 582
    PHA03249; DNA packaging tegument protein UL25; Provisional
    pfam14738
    Location:105 → 188
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2XY62 Q2XY62
Q8T9B8 Q8T9B8
Q9VAM5 Q9VAM5

Gene LinkOut

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