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Conserved domains on  [gi|24651006|ref|NP_651685|]
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bromodomain containing 8 [Drosophila melanogaster]

Protein Classification

bromodomain-containing protein 8( domain architecture ID 10144714)

bromodomain-containing protein 8 (BRD8) may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR)

CATH:  1.20.920.10
Gene Ontology:  GO:0030374|GO:0046966
PubMed:  31582847|28847823|34548613|1350857|26472704

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 729-833 4.11e-45

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99939  Cd Length: 104  Bit Score: 157.14  E-value: 4.11e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 729 RAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYK 808
Cdd:cd05507   1 YRAWKKAILLVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNS 80

                        90       100
                ....*....|....*....|....*
gi 24651006 809 PHtAQHKTARLFVQDCQAIKEFSQL 833
Cdd:cd05507  81 SD-HDVYLMAVEMQREVMSQIQQLL 104
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 111-367 1.07e-04

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.19  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   111 LTEERQAEIKAQMRQdqetyrrIQREIESLQSDAVteqelQDMWLE-----IEKEQEARRIEEMKLENRMReREQRKKDL 185
Cdd:PTZ00108 1099 LTKEKVEKLNAELEK-------KEKELEKLKNTTP-----KDMWLEdldkfEEALEEQEEVEEKEIAKEQR-LKSKTKGK 1165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   186 ASNWRNSSL---AVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLL----TSLLKSPTGNAPATPTPGGAAPAAGGT 258
Cdd:PTZ00108 1166 ASKLRKPKLkkkEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDnkksNSSGSDQEDDEEQKTKPKKSSVKRLKS 1245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   259 GSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSrPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAA 338
Cdd:PTZ00108 1246 KKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPP-PPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKK 1324

                         250       260
                  ....*....|....*....|....*....
gi 24651006   339 KANESGSLVKPEGSGNQEQGVDEATSSAA 367
Cdd:PTZ00108 1325 KKSEKKTARKKKSKTRVKQASASQSSRLL 1353
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 403-708 2.76e-04

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   403 VIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQ 482
Cdd:PHA03307   84 SRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   483 SGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPT-KMEEDGATDSLPKKEDAAEDKSEQESSSQGQNK 561
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   562 AGGSTDEPE--------LIDHQATREAQSKSGKDTAGKPVTMQEKTTTQ-SAPVPVDLHDTDEESSSLTDSSKHDDHPRS 632
Cdd:PHA03307  244 SSGCGWGPEnecplprpAPITLPTRIWEASGWNGPSSRPGPASSSSSPReRSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   633 AKAKPPALKLALDDSKS-----ELELSGTPQPPSAPARTPLLRKLPHRDRSESpmvdddATTASDhstARSTRRRCSSTP 707
Cdd:PHA03307  324 SSSSSTSSSSESSRGAAvspgpSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS------SPAASA---GRPTRRRARAAV 394


                  .
gi 24651006   708 V 708
Cdd:PHA03307  395 A 395
 
Name Accession Description Interval E-value
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 729-833 4.11e-45

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 157.14  E-value: 4.11e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 729 RAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYK 808
Cdd:cd05507   1 YRAWKKAILLVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNS 80

                        90       100
                ....*....|....*....|....*
gi 24651006 809 PHtAQHKTARLFVQDCQAIKEFSQL 833
Cdd:cd05507  81 SD-HDVYLMAVEMQREVMSQIQQLL 104
BROMO smart00297
bromo domain;
733-830 4.09e-10

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 57.67  E-value: 4.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006    733 KKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTA 812
Cdd:smart00297   9 QELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSE 88

                           90
                   ....*....|....*....
gi 24651006    813 QHKTARLFVQDC-QAIKEF 830
Cdd:smart00297  89 VYKDAKKLEKFFeKKLREL 107
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 743-819 3.56e-08

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 51.55  E-value: 3.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24651006   743 LLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARL 819
Cdd:pfam00439   8 LMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 111-367 1.07e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.19  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   111 LTEERQAEIKAQMRQdqetyrrIQREIESLQSDAVteqelQDMWLE-----IEKEQEARRIEEMKLENRMReREQRKKDL 185
Cdd:PTZ00108 1099 LTKEKVEKLNAELEK-------KEKELEKLKNTTP-----KDMWLEdldkfEEALEEQEEVEEKEIAKEQR-LKSKTKGK 1165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   186 ASNWRNSSL---AVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLL----TSLLKSPTGNAPATPTPGGAAPAAGGT 258
Cdd:PTZ00108 1166 ASKLRKPKLkkkEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDnkksNSSGSDQEDDEEQKTKPKKSSVKRLKS 1245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   259 GSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSrPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAA 338
Cdd:PTZ00108 1246 KKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPP-PPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKK 1324

                         250       260
                  ....*....|....*....|....*....
gi 24651006   339 KANESGSLVKPEGSGNQEQGVDEATSSAA 367
Cdd:PTZ00108 1325 KKSEKKTARKKKSKTRVKQASASQSSRLL 1353
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 403-708 2.76e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   403 VIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQ 482
Cdd:PHA03307   84 SRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   483 SGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPT-KMEEDGATDSLPKKEDAAEDKSEQESSSQGQNK 561
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   562 AGGSTDEPE--------LIDHQATREAQSKSGKDTAGKPVTMQEKTTTQ-SAPVPVDLHDTDEESSSLTDSSKHDDHPRS 632
Cdd:PHA03307  244 SSGCGWGPEnecplprpAPITLPTRIWEASGWNGPSSRPGPASSSSSPReRSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   633 AKAKPPALKLALDDSKS-----ELELSGTPQPPSAPARTPLLRKLPHRDRSESpmvdddATTASDhstARSTRRRCSSTP 707
Cdd:PHA03307  324 SSSSSTSSSSESSRGAAvspgpSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS------SPAASA---GRPTRRRARAAV 394


                  .
gi 24651006   708 V 708
Cdd:PHA03307  395 A 395
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 108-182 7.04e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 41.36  E-value: 7.04e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24651006 108 LRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVT--EQELQDMWLEIEKEQEARRIEEMKLENRMREREQRK 182
Cdd:COG2825  48 LEKEFKKRQAELQKLEKELQALQEKLQKEAATLSEEERQkkERELQKKQQELQRKQQEAQQDLQKRQQELLQPILEK 124
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 105-186 1.49e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.83  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   105 ELLLRRLTEERQAEIKAQMRQDQETYRRIQREI------------ESLQSDAVTEQELQDMWLEieKEQEARRIEEMKLE 172
Cdd:pfam13868 205 ELRAKLYQEEQERKERQKEREEAEKKARQRQELqqareeqielkeRRLAEEAEREEEEFERMLR--KQAEDEEIEQEEAE 282

                          90
                  ....*....|....
gi 24651006   173 NRMREREQRKKDLA 186
Cdd:pfam13868 283 KRRMKRLEHRRELE 296
 
Name Accession Description Interval E-value
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 729-833 4.11e-45

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 157.14  E-value: 4.11e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 729 RAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYK 808
Cdd:cd05507   1 YRAWKKAILLVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNS 80

                        90       100
                ....*....|....*....|....*
gi 24651006 809 PHtAQHKTARLFVQDCQAIKEFSQL 833
Cdd:cd05507  81 SD-HDVYLMAVEMQREVMSQIQQLL 104
BROMO smart00297
bromo domain;
733-830 4.09e-10

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 57.67  E-value: 4.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006    733 KKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTA 812
Cdd:smart00297   9 QELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSE 88

                           90
                   ....*....|....*....
gi 24651006    813 QHKTARLFVQDC-QAIKEF 830
Cdd:smart00297  89 VYKDAKKLEKFFeKKLREL 107
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 742-825 9.31e-09

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 53.53  E-value: 9.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 742 MLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFV 821
Cdd:cd04369  13 KKLKRDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLE 92


                ....
gi 24651006 822 QDCQ 825
Cdd:cd04369  93 KLFE 96
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 743-819 3.56e-08

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 51.55  E-value: 3.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24651006   743 LLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARL 819
Cdd:pfam00439   8 LMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 771-824 1.74e-07

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 50.07  E-value: 1.74e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24651006 771 PMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQDC 824
Cdd:cd05492  46 HLDVADIQEKINSEKYTSLEEFKADALLLLHNTAIFHGADSEQYDAARWLYRDT 99
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 752-818 8.95e-06

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 45.09  E-value: 8.95e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24651006 752 FKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTAR 818
Cdd:cd05513  22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAK 88
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 111-367 1.07e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.19  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   111 LTEERQAEIKAQMRQdqetyrrIQREIESLQSDAVteqelQDMWLE-----IEKEQEARRIEEMKLENRMReREQRKKDL 185
Cdd:PTZ00108 1099 LTKEKVEKLNAELEK-------KEKELEKLKNTTP-----KDMWLEdldkfEEALEEQEEVEEKEIAKEQR-LKSKTKGK 1165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   186 ASNWRNSSL---AVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLL----TSLLKSPTGNAPATPTPGGAAPAAGGT 258
Cdd:PTZ00108 1166 ASKLRKPKLkkkEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDnkksNSSGSDQEDDEEQKTKPKKSSVKRLKS 1245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   259 GSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSrPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAA 338
Cdd:PTZ00108 1246 KKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPP-PPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKK 1324

                         250       260
                  ....*....|....*....|....*....
gi 24651006   339 KANESGSLVKPEGSGNQEQGVDEATSSAA 367
Cdd:PTZ00108 1325 KKSEKKTARKKKSKTRVKQASASQSSRLL 1353
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 725-825 1.85e-04

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 41.61  E-value: 1.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 725 RRETRAASKKLFLSIYAMLLD-SKHAA--PFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAH 801
Cdd:cd05504   3 RSEGRHHGPLNLSALEQLLVEiVKHKDswPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFS 82

                        90       100
                ....*....|....*....|....*....
gi 24651006 802 NVLvAYKP-HTAQHKTA----RLFVQDCQ 825
Cdd:cd05504  83 NCF-LYNPeHTSVYKAGtrlqRFFIKRCR 110
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 770-802 2.57e-04

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 41.26  E-value: 2.57e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 24651006 770 RPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHN 802
Cdd:cd05516  46 KPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQN 78
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 403-708 2.76e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   403 VIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQ 482
Cdd:PHA03307   84 SRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   483 SGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPT-KMEEDGATDSLPKKEDAAEDKSEQESSSQGQNK 561
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   562 AGGSTDEPE--------LIDHQATREAQSKSGKDTAGKPVTMQEKTTTQ-SAPVPVDLHDTDEESSSLTDSSKHDDHPRS 632
Cdd:PHA03307  244 SSGCGWGPEnecplprpAPITLPTRIWEASGWNGPSSRPGPASSSSSPReRSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   633 AKAKPPALKLALDDSKS-----ELELSGTPQPPSAPARTPLLRKLPHRDRSESpmvdddATTASDhstARSTRRRCSSTP 707
Cdd:PHA03307  324 SSSSSTSSSSESSRGAAvspgpSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS------SPAASA---GRPTRRRARAAV 394


                  .
gi 24651006   708 V 708
Cdd:PHA03307  395 A 395
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 739-809 2.89e-04

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 40.60  E-value: 2.89e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24651006 739 IYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKP 809
Cdd:cd05505   8 ILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYEN 78
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 108-182 7.04e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 41.36  E-value: 7.04e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24651006 108 LRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVT--EQELQDMWLEIEKEQEARRIEEMKLENRMREREQRK 182
Cdd:COG2825  48 LEKEFKKRQAELQKLEKELQALQEKLQKEAATLSEEERQkkERELQKKQQELQRKQQEAQQDLQKRQQELLQPILEK 124
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 105-186 1.49e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.83  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   105 ELLLRRLTEERQAEIKAQMRQDQETYRRIQREI------------ESLQSDAVTEQELQDMWLEieKEQEARRIEEMKLE 172
Cdd:pfam13868 205 ELRAKLYQEEQERKERQKEREEAEKKARQRQELqqareeqielkeRRLAEEAEREEEEFERMLR--KQAEDEEIEQEEAE 282

                          90
                  ....*....|....
gi 24651006   173 NRMREREQRKKDLA 186
Cdd:pfam13868 283 KRRMKRLEHRRELE 296
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 743-802 2.42e-03

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 38.41  E-value: 2.42e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 743 LLDSKHAA---PFKRP-------FHDEHaqrhaDLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHN 802
Cdd:cd05498  12 LFSKKHKAyawPFYKPvdpealgLHDYH-----DIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSN 76
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 108-182 3.76e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 40.24  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   108 LRRLTEERQAEIKAQMRQDQEtyrrIQREieslqsdavteqELQDMWLEIEKEQEARRIEEM------KLENRMREREQR 181
Cdd:pfam07946 259 LKKAKKTREEEIEKIKKAAEE----ERAE------------EAQEKKEEAKKKEREEKLAKLspeeqrKYEEKERKKEQR 322


                  .
gi 24651006   182 K 182
Cdd:pfam07946 323 K 323
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 109-183 4.92e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.90  E-value: 4.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24651006   109 RRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEqELQDMWLEIEKEQEARRIEEMKLENRMREREQRKK 183
Cdd:pfam13868 175 REEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQE-EQERKERQKEREEAEKKARQRQELQQAREEQIELK 248
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 79-186 5.22e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006    79 EATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIK-------------AQMRQDQETYRRIQREIESLQSDAV 145
Cdd:pfam17380 408 EEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMErvrleeqerqqqvERLRQQEEERKRKKLELEKEKRDRK 487

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24651006   146 TEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLA 186
Cdd:pfam17380 488 RAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKA 528
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 734-809 7.02e-03

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 36.92  E-value: 7.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 734 KLFLSIYAMLLDSKHAAPFKRP-------FHDEHaqrhaDLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLvA 806
Cdd:cd05506   3 KQCGTLLRKLMKHKWGWVFNAPvdvvalgLPDYF-----DIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAM-R 76


                ...
gi 24651006 807 YKP 809
Cdd:cd05506  77 YNP 79
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 106-188 7.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 7.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006 106 LLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSD-AVTEQELQDMWLEIEKEQEARRI---EEMKLENRMREREQR 181
Cdd:COG1196 231 LLKLRELEAELEELEAELEELEAELEELEAELAELEAElEELRLELEELELELEEAQAEEYEllaELARLEQDIARLEER 310


                ....*..
gi 24651006 182 KKDLASN 188
Cdd:COG1196 311 RRELEER 317
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 771-802 8.59e-03

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 36.49  E-value: 8.59e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24651006 771 PMDFPTIKRNIDSGFIRSLSELHRDVLLMAHN 802
Cdd:cd05499  45 PMDLGTISKKLQNGQYQSAKEFERDVRLIFKN 76
RNase_Y_N pfam12072
RNase Y N-terminal region;
106-209 9.68e-03

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 38.33  E-value: 9.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24651006   106 LLLRRLTEERQAEIkaqmrqdQETYRRI----QREIESLQSDAVTE--QELQDMWLEIEKEQEARRIEEMKLENRMRERE 179
Cdd:pfam12072  19 LVRKSIAEAKIGSA-------EELAKRIieeaKKEAETKKKEALLEakEEIHKLRAEAERELKERRNELQRQERRLLQKE 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24651006   180 QR--KKDLASNWRNSSLAVKRSNQAADTTSVD 209
Cdd:pfam12072  92 ETldRKDESLEKKEESLEKKEKELEAQQQQLE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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