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AdipoR Adiponectin receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42656, updated on 9-Dec-2024

Summary

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Official Symbol
AdipoRprovided by FlyBase
Official Full Name
Adiponectin receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0038984
Locus tag
Dmel_CG5315
See related
AllianceGenome:FB:FBgn0038984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5315; dAdipoR; Dmel\CG5315
Summary
Predicted to enable protein-hormone receptor activity. Involved in several processes, including female germ-line stem cell population maintenance; positive regulation of insulin secretion; and triglyceride homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and larval circulatory system. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; metabolic dysfunction-associated steatotic liver disease; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See AdipoR in Genome Data Viewer
Location:
94B3-94B3; 3-75 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22543693..22547846, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18369415..18373568, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45646 Neighboring gene long non-coding RNA:CR45647 Neighboring gene antisense RNA:CR44062 Neighboring gene james bond Neighboring gene stuck in traffic

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Brain adiponectin signaling controls peripheral insulin response in Drosophila. Arquier N, et al. Nat Commun, 2021 Sep 24. PMID 34561451, Free PMC Article
  2. Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion. Kwak SJ, et al. PLoS One, 2013. PMID 23874700, Free PMC Article
  3. Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance. Laws KM, et al. Dev Biol, 2015 Mar 15. PMID 25576925, Free PMC Article
  4. Regulation of adult female germline stem cells by nutrient-responsive signaling. Lin KY, et al. Curr Opin Insect Sci, 2020 Feb. PMID 32070932
  5. A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Szafer-Glusman E, et al. Curr Biol, 2008 Sep 23. PMID 18804373, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain adiponectin signaling controls peripheral insulin response in Drosophila.
    Title: Brain adiponectin signaling controls peripheral insulin response in Drosophila.
  2. There is an intrinsic requirement for AdipoR in germline stem cell maintenance in the Drosophila ovary.
    Title: Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adiponectin receptor
Names
AdipoR-PA
AdipoR-PB
AdipoR-PC
AdipoR-PD
AdipoR-PE
CG5315-PA
CG5315-PB
CG5315-PC
CG5315-PD
CG5315-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22543693..22547846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142804.3 → NP_651061.1  adiponectin receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCY8, Q9VCY9
    UniProtKB/TrEMBL
    A4V392
    Related
    FBpp0083675
    Conserved Domains (1) summary
    pfam03006
    Location:198 → 419
    HlyIII; Haemolysin-III related

  2. NM_170019.2 → NP_732758.1  adiponectin receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732758.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCY8, Q9VCY9
    UniProtKB/TrEMBL
    A4V392
    Related
    FBpp0083676
    Conserved Domains (1) summary
    pfam03006
    Location:198 → 419
    HlyIII; Haemolysin-III related

  3. NM_001260310.2 → NP_001247239.1  adiponectin receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCY8, Q9VCY9
    UniProtKB/TrEMBL
    A4V392
    Conserved Domains (1) summary
    pfam03006
    Location:198 → 419
    HlyIII; Haemolysin-III related

  4. NM_001275915.1 → NP_001262844.1  adiponectin receptor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262844.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCY8, Q9VCY9
    UniProtKB/TrEMBL
    A4V392
    Conserved Domains (1) summary
    pfam03006
    Location:198 → 419
    HlyIII; Haemolysin-III related

  5. NM_170020.2 → NP_732759.2  adiponectin receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732759.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP81
    Related
    FBpp0083677
    Conserved Domains (1) summary
    pfam03006
    Location:116 → 337
    HlyIII; Haemolysin-III related
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V392 A4V392
Q9VCY8.2 Q9VCY8

Gene LinkOut

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