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Conserved domains on  [gi|45551946|ref|NP_732759|]
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adiponectin receptor, isoform B [Drosophila melanogaster]

Protein Classification

hemolysin III family protein( domain architecture ID 10503285)

hemolysin III family protein is an integral membrane protein that may have hemolytic and cytotoxic activity against a broad range of species and cell types

Gene Ontology:  GO:0016020|GO:0015267
TCDB:  1.C.113

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 116-337 3.20e-92

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


:

Pssm-ID: 427098  Cd Length: 222  Bit Score: 275.30  E-value: 3.20e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   116 FRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYC 195
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALATIDSQLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLDYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   196 GIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEG 275
Cdd:pfam03006  81 GIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSKPAPRWLRTAVYILMGWSGIIPIAHRALALG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45551946   276 WFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHY 337
Cdd:pfam03006 161 GAGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 116-337 3.20e-92

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 275.30  E-value: 3.20e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   116 FRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYC 195
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALATIDSQLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLDYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   196 GIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEG 275
Cdd:pfam03006  81 GIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSKPAPRWLRTAVYILMGWSGIIPIAHRALALG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45551946   276 WFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHY 337
Cdd:pfam03006 161 GAGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
 121-337 1.85e-11

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 62.73  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   121 ETGNIWTHLLGCIAFIgVALYFISRPSVEIQTQ-EKIVFGAFFIGAIVCLGFSFAFHTLSCHSvEMGRLFSKLDYCGIAL 199
Cdd:TIGR01065   2 EIANAITHGIGAVLSI-IALALLVIYSWDHGGAvAVLGFSIYGISLILLFLVSTLYHSIPKGS-KAKNWLRKIDHSMIYV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   200 LIMGSFVPWLYYGFYCHyqPKVIYLSVVSILGILSIV-VSLWDKfsepalRPLRAGVFMSFGLSGVIPAIHYSIMEgwfs 278
Cdd:TIGR01065  80 LIAGTYTPFLLLALPGP--LGWTVLWIIWGLAIGGIIyKLFFHK------RPRWLSLFLYLIMGWLVVLVIKPLYH---- 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 45551946   279 QMSRASLGWLILMGLLYILGALLYALRVPERWfpgkfdiwgQSHQIFHILVIAAAFVHY 337
Cdd:TIGR01065 148 NLPGAGFSLLAAGGLLYTVGAIFYALKWPIPF---------TYHAIWHLFVLGASACHF 197
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 116-337 3.20e-92

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 275.30  E-value: 3.20e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   116 FRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYC 195
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALATIDSQLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLDYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   196 GIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEG 275
Cdd:pfam03006  81 GIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSKPAPRWLRTAVYILMGWSGIIPIAHRALALG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45551946   276 WFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHY 337
Cdd:pfam03006 161 GAGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
 121-337 1.85e-11

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 62.73  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   121 ETGNIWTHLLGCIAFIgVALYFISRPSVEIQTQ-EKIVFGAFFIGAIVCLGFSFAFHTLSCHSvEMGRLFSKLDYCGIAL 199
Cdd:TIGR01065   2 EIANAITHGIGAVLSI-IALALLVIYSWDHGGAvAVLGFSIYGISLILLFLVSTLYHSIPKGS-KAKNWLRKIDHSMIYV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45551946   200 LIMGSFVPWLYYGFYCHyqPKVIYLSVVSILGILSIV-VSLWDKfsepalRPLRAGVFMSFGLSGVIPAIHYSIMEgwfs 278
Cdd:TIGR01065  80 LIAGTYTPFLLLALPGP--LGWTVLWIIWGLAIGGIIyKLFFHK------RPRWLSLFLYLIMGWLVVLVIKPLYH---- 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 45551946   279 QMSRASLGWLILMGLLYILGALLYALRVPERWfpgkfdiwgQSHQIFHILVIAAAFVHY 337
Cdd:TIGR01065 148 NLPGAGFSLLAAGGLLYTVGAIFYALKWPIPF---------TYHAIWHLFVLGASACHF 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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