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Dph4 Diphthamide biosynthesis 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40686, updated on 9-Dec-2024

Summary

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Official Symbol
Dph4provided by FlyBase
Official Full Name
Diphthamide biosynthesis 4provided by FlyBase
Primary source
FLYBASE:FBgn0037350
Locus tag
Dmel_CG2911
See related
AllianceGenome:FB:FBgn0037350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2911; Dmel\CG2911
Summary
Predicted to enable ATPase activator activity. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dph4 in Genome Data Viewer
Location:
83B6-83B6; 3-47.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5622119..5624125, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1447841..1449847, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Antisense transcript of Rga Neighboring gene Regena Neighboring gene stable intronic sequence RNA 1 Neighboring gene antisense RNA:CR46135 Neighboring gene Another transcription unit Neighboring gene Spec2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L13A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. Cinà DP, et al. Am J Physiol Renal Physiol, 2019 Dec 1. PMID 31566424, Free PMC Article
  2. Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition. Vaid R, et al. Nucleic Acids Res, 2020 May 21. PMID 32297950, Free PMC Article
  3. Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo. Rousset R, et al. PLoS Genet, 2017 Feb. PMID 28231245, Free PMC Article
  4. RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology. Raut S, et al. G3 (Bethesda), 2017 Jul 5. PMID 28500055, Free PMC Article
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diphthamide biosynthesis 4
Names
CG2911-PA
CG2911-PB
Dph4-PA
Dph4-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5622119..5624125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104219.2 → NP_001097689.1  diphthamide biosynthesis 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XYG4, Q9VNE8
    Conserved Domains (2) summary
    pfam00226
    Location:3 → 72
    DnaJ; DnaJ domain
    pfam05207
    Location:135 → 179
    zf-CSL; CSL zinc finger

  2. NM_141302.3 → NP_649559.1  diphthamide biosynthesis 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XYG4, Q9VNE8
    Related
    FBpp0078389
    Conserved Domains (2) summary
    pfam00226
    Location:3 → 72
    DnaJ; DnaJ domain
    pfam05207
    Location:135 → 179
    zf-CSL; CSL zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2XYG4 Q2XYG4
Q9VNE8 Q9VNE8

Gene LinkOut

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