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ak4 adenylate kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 406590, updated on 9-Dec-2024

Summary

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Official Symbol
ak4provided by ZNC
Official Full Name
adenylate kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2505
See related
Ensembl:ENSDARG00000006546 AllianceGenome:ZFIN:ZDB-GENE-040426-2505
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ak3l1; zgc:85790; wu:fc37g02
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in AMP metabolic process and nucleoside triphosphate biosynthetic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process and phosphorylation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in axis; nervous system; neural tube; pronephric duct; and somite. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See ak4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (31352145..31361591, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (31365231..31377950, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490216 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 6 Neighboring gene uncharacterized LOC137495976 Neighboring gene microRNA 101a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article
  2. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside triphosphate adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, phosphate group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside triphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenylate kinase 4, mitochondrial
Names
adenylate kinase 3-like 1
NP_998464.1
XP_005165930.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213299.1 → NP_998464.1  adenylate kinase 4, mitochondrial

    See identical proteins and their annotated locations for NP_998464.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068387
    UniProtKB/TrEMBL
    A0A8N1TRF3, Q6NUY0
    Related
    ENSDARP00000024387.6, ENSDART00000027550.8
    Conserved Domains (2) summary
    cd01428
    Location:6 → 192
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:6 → 210
    adk; adenylate kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    31352145..31361591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165873.4 → XP_005165930.1  adenylate kinase 4, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005165930.1

    UniProtKB/TrEMBL
    A0A8N1TRF3, Q6NUY0
    Related
    ENSDARP00000114953.1, ENSDART00000134370.2
    Conserved Domains (2) summary
    cd01428
    Location:6 → 192
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:6 → 210
    adk; adenylate kinase
Nucleotide Protein Strain
Heading Accession and Version

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