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Conserved domains on  [gi|47086929|ref|NP_998464|]
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adenylate kinase 4, mitochondrial [Danio rerio]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492251)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 6-210 9.28e-86

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


:

Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 252.93  E-value: 9.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKY--S 83
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNenG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    84 WLLDGFPRTLAQAEALNSSCD--LDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDD 161
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 47086929   162 RPEALVARLRHYKDVAKPVIDFYKAKGILYTFSDT-ETDRIWPNINTLLS 210
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
 
Name Accession Description Interval E-value
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 6-210 9.28e-86

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 252.93  E-value: 9.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKY--S 83
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNenG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    84 WLLDGFPRTLAQAEALNSSCD--LDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDD 161
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 47086929   162 RPEALVARLRHYKDVAKPVIDFYKAKGILYTFSDT-ETDRIWPNINTLLS 210
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK pfam00406
Adenylate kinase;
9-187 1.18e-84

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 249.15  E-value: 1.18e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLE-EMTKYSWLLD 87
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    88 GFPRTLAQAEALNSS----CDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDDRP 163
Cdd:pfam00406  81 GFPRTVPQAEALEELlergIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 47086929   164 EALVARLRHYKDVAKPVIDFYKAK 187
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 6-192 1.92e-80

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 239.64  E-value: 1.92e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPdCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929  85 LLDGFPRTLAQAEALNS-----SCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQE 159
Cdd:COG0563  82 ILDGFPRTVAQAEALDEllaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                       170       180       190
                ....*....|....*....|....*....|...
gi 47086929 160 DDRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:COG0563 162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVE 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 6-192 2.99e-79

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 235.98  E-value: 2.99e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPdCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929  85 LLDGFPRTLAQAEALNSSCD----LDVAINLNIPLETLKERLRHRWIHPPSGRVYNMcfnppriqGLDDITGEALIQQED 160
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSD 152

                       170       180       190
                ....*....|....*....|....*....|..
gi 47086929 161 DRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:cd01428 153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVE 184
adk PRK00279
adenylate kinase; Reviewed
 6-210 8.21e-75

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 225.41  E-value: 8.21e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPdCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEALNSSC-----DLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQE 159
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 47086929  160 DDRPEALVARLRHYKDVAKPVIDFYKAKGILYTFSDTET-DRIWPNINTLLS 210
Cdd:PRK00279 162 DDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSiDEVFADILKALG 213
 
Name Accession Description Interval E-value
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 6-210 9.28e-86

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 252.93  E-value: 9.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKY--S 83
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNenG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    84 WLLDGFPRTLAQAEALNSSCD--LDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDD 161
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 47086929   162 RPEALVARLRHYKDVAKPVIDFYKAKGILYTFSDT-ETDRIWPNINTLLS 210
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK pfam00406
Adenylate kinase;
9-187 1.18e-84

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 249.15  E-value: 1.18e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLE-EMTKYSWLLD 87
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    88 GFPRTLAQAEALNSS----CDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDDRP 163
Cdd:pfam00406  81 GFPRTVPQAEALEELlergIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 47086929   164 EALVARLRHYKDVAKPVIDFYKAK 187
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 6-192 1.92e-80

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 239.64  E-value: 1.92e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPdCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929  85 LLDGFPRTLAQAEALNS-----SCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQE 159
Cdd:COG0563  82 ILDGFPRTVAQAEALDEllaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                       170       180       190
                ....*....|....*....|....*....|...
gi 47086929 160 DDRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:COG0563 162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVE 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 6-192 2.99e-79

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 235.98  E-value: 2.99e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPdCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929  85 LLDGFPRTLAQAEALNSSCD----LDVAINLNIPLETLKERLRHRWIHPPSGRVYNMcfnppriqGLDDITGEALIQQED 160
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSD 152

                       170       180       190
                ....*....|....*....|....*....|..
gi 47086929 161 DRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:cd01428 153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVE 184
adk PRK00279
adenylate kinase; Reviewed
 6-210 8.21e-75

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 225.41  E-value: 8.21e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPdCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEALNSSC-----DLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQE 159
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 47086929  160 DDRPEALVARLRHYKDVAKPVIDFYKAKGILYTFSDTET-DRIWPNINTLLS 210
Cdd:PRK00279 162 DDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSiDEVFADILKALG 213
PLN02674 PLN02674
adenylate kinase
 6-190 1.21e-53

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 172.38  E-value: 1.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLprlEEMTKYS-- 83
Cdd:PLN02674  33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIID---EAMKKPScq 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   84 --WLLDGFPRTLAQAEALNS-----SCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALI 156
Cdd:PLN02674 110 kgFILDGFPRTVVQAQKLDEmlakqGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLI 189

                        170       180       190
                 ....*....|....*....|....*....|....
gi 47086929  157 QQEDDRPEALVARLRHYKDVAKPVIDFYKAKGIL 190
Cdd:PLN02674 190 QRKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVV 223
PRK14530 PRK14530
adenylate kinase; Provisional
 6-205 4.53e-44

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 146.86  E-value: 4.53e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVREN-ISSKTDAGVLAKT---YINKGLLVPDHVMTRLLLPRLEEMTK 81
Cdd:PRK14530   5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANkQMDISDMDTEYDTpgeYMDAGELVPDAVVNEIVEEALSDADG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   82 YswLLDGFPRTLAQAEALNSSCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDD 161
Cdd:PRK14530  85 F--VLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGELIQRDDD 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 47086929  162 RPEALVARLRHYKDVAKPVIDFYKAKGILYTFSDTET-DRIWPNI 205
Cdd:PRK14530 163 TEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVWADI 207
PLN02459 PLN02459
probable adenylate kinase
 8-193 1.49e-40

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 139.21  E-value: 1.49e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLE---EMTKYSW 84
Cdd:PLN02459  33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEageEEGESGF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEALNSSCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNM-CFNPPRIQGLDDITGEAL-------- 155
Cdd:PLN02459 113 ILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVaDIDLKGEDGRPGIVMPPLlpppecas 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 47086929  156 --IQQEDDRPEALVARLRHYKDVAKPVIDFYKAKGILYTF 193
Cdd:PLN02459 193 klITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
PLN02842 PLN02842
nucleotide kinase
 8-184 2.13e-38

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 138.84  E-value: 2.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRL--EEMTKYSWL 85
Cdd:PLN02842   1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLsrEDAKEKGWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   86 LDGFPRTLAQAEALNS-SCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRiqglDDITGEALIQQEDDRPE 164
Cdd:PLN02842  81 LDGYPRSFAQAQSLEKlKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----SEEIKARLITRPDDTEE 156

                        170       180
                 ....*....|....*....|
gi 47086929  165 ALVARLRHYKDVAKPVIDFY 184
Cdd:PLN02842 157 KVKARLQIYKKNAEAILSTY 176
adk PRK02496
adenylate kinase; Provisional
 6-209 7.82e-37

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 127.56  E-value: 7.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:PRK02496   3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPdAANGW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEAL-------NSSCDLdvAINLNIPLETLKERLRHRwihppsGRvynmcfnppriqgldditgealiq 157
Cdd:PRK02496  83 ILDGFPRKVTQAAFLdellqeiGQSGER--VVNLDVPDDVVVERLLAR------GR------------------------ 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 47086929  158 qEDDRPEALVARLRHYKDVAKPVIDFYKAKGILYTFS-DTETDRIWPNINTLL 209
Cdd:PRK02496 131 -KDDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDgNQSVEAVTTELKAAL 182
PRK14526 PRK14526
adenylate kinase; Provisional
 8-184 1.45e-35

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 124.96  E-value: 1.45e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKY-SWLL 86
Cdd:PRK14526   4 VFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNdNFIL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   87 DGFPRTLAQAEALNSSCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQEDDRPEAL 166
Cdd:PRK14526  84 DGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKEESL 163

                        170
                 ....*....|....*...
gi 47086929  167 VARLRHYKDVAKPVIDFY 184
Cdd:PRK14526 164 KTRLQEYKLQTKPLIEFY 181
PRK14528 PRK14528
adenylate kinase; Provisional
 6-190 8.08e-33

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 117.03  E-value: 8.08e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREAdCKNGF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEAL-----NSSCDLDVAINLNIPLETLKERLRHRWIhppsgrvynmcfnpprIQGldditgealiqQE 159
Cdd:PRK14528  83 LLDGFPRTVEQADALdallkNEGKSIDKAINLEVPDGELLKRLLGRAE----------------IEG-----------RA 135

                        170       180       190
                 ....*....|....*....|....*....|.
gi 47086929  160 DDRPEALVARLRHYKDVAKPVIDFYKAKGIL 190
Cdd:PRK14528 136 DDNEATIKNRLDNYNKKTLPLLDFYAAQKKL 166
PRK14531 PRK14531
adenylate kinase; Provisional
 6-192 1.70e-32

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 116.06  E-value: 1.70e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKYSWL 85
Cdd:PRK14531   4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSGGWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   86 LDGFPRTLAQAEALNSSCDldvaiNLNIPLET--LKErlrhrwihppsgrvynmcfnppriqgLDDitgEALIQ------ 157
Cdd:PRK14531  84 LDGFPRTVAQAEALEPLLE-----ELKQPIEAvvLLE--------------------------LDD---AVLIErllarg 129

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 47086929  158 QEDDRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:PRK14531 130 RADDNEAVIRNRLEVYREKTAPLIDHYRQRGLLQS 164
PRK14527 PRK14527
adenylate kinase; Provisional
 6-192 1.34e-31

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 114.12  E-value: 1.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVI-MGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKYSW 84
Cdd:PRK14527   7 KVVIfLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEALNS-----SCDLDVAINLNIPLETLKERLRHRwihppsgrvynmcfnppriqgldditgEALIQQE 159
Cdd:PRK14527  87 IFDGFPRTLAQAEALDRlleelGARLLAVVLLEVPDEELIRRIVER---------------------------ARQEGRS 139

                        170       180       190
                 ....*....|....*....|....*....|...
gi 47086929  160 DDRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:PRK14527 140 DDNEETVRRRQQVYREQTQPLVDYYEARGHLKR 172
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 9-210 8.05e-31

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 112.08  E-value: 8.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDA-GVLAKTYINKGLLVPDHVMTRLLLPRLEEMTK-YSWLL 86
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSEnGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSsKKFLI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    87 DGFPRTLAQAEALNSSCDLDVAIN----LNIPLETLKERLRHRwiHPPSGRVynmcfnppriqgldditgealiqqeDDR 162
Cdd:TIGR01359  84 DGFPRNEENLEAWEKLMDNKVNFKfvlfFDCPEETMIKRLLKR--GQTSGRV-------------------------DDN 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 47086929   163 PEALVARLRHYKDVAKPVIDFYKAKGILYTFSDTET-DRIWPNINTLLS 210
Cdd:TIGR01359 137 IETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSvEEVFEDVEKIFA 185
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 6-189 1.99e-29

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 109.50  E-value: 1.99e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTK---Y 82
Cdd:PTZ00088   8 KIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDdcfK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   83 SWLLDGFPRTLAQAEALNSSCDLDVAINLNIPLETLKERLRHRWIHPPSGRVYNMC------FNPPRI---QGLDDITGE 153
Cdd:PTZ00088  88 GFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIAhirsdpYDMPPIlppADCEGCKGN 167

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 47086929  154 ALIQQEDDRPEALVA-RLRHYKDVAKPVIDFYKAKGI 189
Cdd:PTZ00088 168 PKLQKRSDDTEEIVAhRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 8-172 9.37e-29

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 107.50  E-value: 9.37e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKYSWLLD 87
Cdd:PRK14529   4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   88 GFPRTLAQAEALNSS-----CDLDVAINLNIPLETLKERLRHRWI------HP---------PSGRVYNMCfnppriqgl 147
Cdd:PRK14529  84 GFPRNKVQAEKLWEAlqkegMKLDYVIEILLPREVAKNRIMGRRLckndnnHPnnifidaikPDGDVCRVC--------- 154

                        170       180
                 ....*....|....*....|....*
gi 47086929  148 dditGEALIQQEDDRPEALVARlRH 172
Cdd:PRK14529 155 ----GGELSTRADDQDEEAINK-RH 174
PRK13808 PRK13808
adenylate kinase; Provisional
 6-192 9.73e-29

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 110.36  E-value: 9.73e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    6 RAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSW 84
Cdd:PRK13808   2 RLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPdAANGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEALNS-----SCDLDVAINLNIPLETLKERLRHrwihppsgRVYNMcfnppRIQgldditGEALiqQE 159
Cdd:PRK13808  82 ILDGFPRTVPQAEALDAllkdkQLKLDAVVELRVNEGALLARVET--------RVAEM-----RAR------GEEV--RA 140

                        170       180       190
                 ....*....|....*....|....*....|...
gi 47086929  160 DDRPEALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:PRK13808 141 DDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLT 173
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 9-192 3.54e-27

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 102.59  E-value: 3.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLL---LPRLEEMTKySWL 85
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLkdaMVAALGTSK-GFL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    86 LDGFPRTLAQAEALNSSC-DLDVAINLNIPLETLKERLRHRwiHPPSGRVynmcfnppriqgldditgealiqqeDDRPE 164
Cdd:TIGR01360  87 IDGYPREVKQGEEFERRIgPPTLVLYFDCSEDTMVKRLLKR--AETSGRV-------------------------DDNEK 139

                         170       180
                  ....*....|....*....|....*...
gi 47086929   165 ALVARLRHYKDVAKPVIDFYKAKGILYT 192
Cdd:TIGR01360 140 TIKKRLETYYKATEPVIAYYETKGKLRK 167
PRK14532 PRK14532
adenylate kinase; Provisional
 8-199 7.09e-26

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 99.13  E-value: 7.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKYS-WLL 86
Cdd:PRK14532   4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGgAIF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   87 DGFPRTLAQAEALNS-----SCDLDVAINLNIPLETLKERLRHRWihPPSGRvynmcfnppriqgldditgealiqqEDD 161
Cdd:PRK14532  84 DGFPRTVAQAEALDKmlasrGQKIDVVIRLKVDDEALIERIVKRF--EEQGR-------------------------PDD 136

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 47086929  162 RPEALVARLRHYKDVAKPVIDFYKAKGILytfsdTETD 199
Cdd:PRK14532 137 NPEVFVTRLDAYNAQTAPLLPYYAGQGKL-----TEVD 169
AAA_17 pfam13207
AAA domain;
10-125 1.31e-24

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 94.23  E-value: 1.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    10 MGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTdaGVLAKTYINKGLLVPDHVMTRLLLPRLEEM-TKYSWLLDG 88
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEaGEGGVIVDG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 47086929    89 FPRTLAQAEAL-------NSSCDLDVAINLNIPLETLKERLRHR 125
Cdd:pfam13207  79 HPRIKTPAGYLpglpvevLRELKPDAIILLEADPEEILERRLKD 122
PLN02200 PLN02200
adenylate kinase family protein
 5-210 1.60e-24

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 96.89  E-value: 1.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    5 FRAVIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGVLAKTYINKGLLVPDHVMTRLLLPRLEEMTKYSW 84
Cdd:PLN02200  44 FITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNKF 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   85 LLDGFPRTLAQAEALNS--SCDLDVAINLNIPLETLKERLRHRwihpPSGRVynmcfnppriqgldditgealiqqeDDR 162
Cdd:PLN02200 124 LIDGFPRTEENRIAFERiiGAEPNVVLFFDCPEEEMVKRVLNR----NQGRV-------------------------DDN 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 47086929  163 PEALVARLRHYKDVAKPVIDFYKAKGILYTFSDTET-DRIWPNINTLLS 210
Cdd:PLN02200 175 IDTIKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTvDEIFEQVRPIFA 223
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 125-160 7.31e-13

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 60.55  E-value: 7.31e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47086929   125 RWIHPPSGRVYNMCFNPPRIQGLDDITGEALIQQED 160
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
AAA_18 pfam13238
AAA domain;
8-125 1.53e-07

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 48.58  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929     8 VIMGPPGSGKGTISERIAHNFGLkHLSSGDFVRENISSKTDAGVLAKTYInkgllVPDHVMTRLL--LPRLEEMTKYS-W 84
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETRESKR-----LDEDKLDRLLdlLEENAALEEGGnL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 47086929    85 LLDGFPrtlaqAEALNSSCDLDVAINLNIPLETLKERLRHR 125
Cdd:pfam13238  76 IIDGHL-----AELEPERAKDLVGIVLRASPEELLERLEKR 111
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 8-41 2.66e-07

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 48.96  E-value: 2.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 47086929     8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRE 41
Cdd:TIGR02173   4 TISGPPGSGKTTVAKILAEKLSLKLISAGDIFRE 37
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 8-128 9.87e-07

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 46.86  E-value: 9.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGV-LAKtyinkgllvpdhvmtRLLLPRLEEMT--KYSW 84
Cdd:cd02021   3 VVMGVSGSGKSTVGKALAERLGAPFIDGDDLHPPANIAKMAAGIpLND---------------EDRWPWLQALTdaLLAK 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47086929  85 LLDGFPRTLAQAEALNSS---------CDLDVA-INLNIPLETLKERLRHRWIH 128
Cdd:cd02021  68 LASAGEGVVVACSALKRIyrdilrggaANPRVRfVHLDGPREVLAERLAARKGH 121
PRK04182 PRK04182
cytidylate kinase; Provisional
 8-41 1.64e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 46.72  E-value: 1.64e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 47086929    8 VIMGPPGSGKGTISERIAHNFGLKHLSSGDFVRE 41
Cdd:PRK04182   4 TISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 9-46 1.75e-06

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 45.94  E-value: 1.75e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47086929   9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSK 46
Cdd:cd02020   4 IDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKL 41
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
8-125 1.89e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 43.36  E-value: 1.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   8 VIMGPPGSGKGTISERIAHNFGLKHLSSgDFVRENissktdagvLAKTYInkGLLVPDHVMTRLLLPRLEEMTK------ 81
Cdd:COG0645   3 LVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKR---------LFGAGL--APLERSPEATARTYARLLALARellaag 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47086929  82 YSWLLD-GFP----RTLAQAEALNSSCDLdVAINLNIPLETLKERLRHR 125
Cdd:COG0645  71 RSVILDaTFLrraqREAFRALAEEAGAPF-VLIWLDAPEEVLRERLEAR 118
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 8-125 3.57e-05

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 42.79  E-value: 3.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929   8 VIMGPPGSGKGTISERIAHNFGLK-----HLSSGDFvRENISSKTDAgvlAKTYINkglLVPDHVMTRLllpRLEEMTKY 82
Cdd:COG4088   8 ILTGPPGSGKTTFAKALAQRLYAEgiavaLLHSDDF-RRFLVNESFP---KETYEE---VVEDVRTTTA---DNALDNGY 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47086929  83 SWLLDG---FPRTLAQAEALnSSCDLDVA-INLNIPLETLKERLRHR 125
Cdd:COG4088  78 SVIVDGtfyYRSWQRDFRNL-AKHKAPIHiIYLKAPLETALRRNRER 123
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
11-36 1.45e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 38.47  E-value: 1.45e-03
                        10        20
                ....*....|....*....|....*.
gi 47086929  11 GPPGSGKGTISERIAHNFGLKHLSSG 36
Cdd:COG0283   7 GPAGSGKSTVAKALAKRLGYHYLDTG 32
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
8-125 1.57e-03

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 38.00  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086929    8 VIMGPPGSGKGTISeRIAHNFGLKHLSSGDFVRENISS----KTDAGVLAKTYINKGLLVPDHVmTRLLLPRLEEMTKYS 83
Cdd:PRK01184   5 GVVGMPGSGKGEFS-KIAREMGIPVVVMGDVIREEVKKrglePTDENIGKVAIDLRKELGMDAV-AKRTVPKIREKGDEV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 47086929   84 WLLDGFpRTLAQAEALNSSCDLD---VAInlNIPLETLKERLRHR 125
Cdd:PRK01184  83 VVIDGV-RGDAEVEYFRKEFPEDfilIAI--HAPPEVRFERLKKR 124
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
9-51 2.87e-03

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 38.49  E-value: 2.87e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 47086929    9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVRENISSKTDAGV 51
Cdd:PRK11860 447 IDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGV 489
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 9-40 3.21e-03

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 37.28  E-value: 3.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 47086929     9 IMGPPGSGKGTISERIAHNFGLKHLSSGDFVR 40
Cdd:pfam02224   3 IDGPSGSGKSTVARILARKLGYKYLDTGAMYR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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