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CRIF CR6-interacting factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40395, updated on 4-Jan-2025

Summary

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Official Symbol
CRIFprovided by FlyBase
Official Full Name
CR6-interacting factorprovided by FlyBase
Primary source
FLYBASE:FBgn0037102
Locus tag
Dmel_CG7172
See related
AllianceGenome:FB:FBgn0037102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.316; CG7172; dCRIF; Dmel\CG7172
Summary
Involved in RNAi-mediated antiviral immune response and siRNA processing. Located in perinuclear region of cytoplasm. Is expressed in adult head. Orthologous to human GADD45GIP1 (GADD45G interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CRIF in Genome Data Viewer
Location:
78D6-78D6; 3-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21568059..21568898, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21561159..21561998, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Capability receptor Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 5 Neighboring gene mir-193 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement for CRIF1 in RNA interference and Dicer-2 stability. Lim SJ, et al. RNA Biol, 2014. PMID 25483042, Free PMC Article
  2. A map of directional genetic interactions in a metazoan cell. Fischer B, et al. Elife, 2015 Mar 6. PMID 25748138, Free PMC Article
  3. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article
  4. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article
  5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in RNAi-mediated antiviral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CR6-interacting factor
Names
CG7172-PA
CRIF-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21568059..21568898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141076.5 → NP_649333.1  CR6-interacting factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649333.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP13
    Related
    FBpp0078032
    Conserved Domains (1) summary
    pfam10147
    Location:29 → 231
    CR6_interact; Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP13 Q9VP13

Gene LinkOut

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