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Conserved domains on  [gi|21358081|ref|NP_649333|]
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CR6-interacting factor [Drosophila melanogaster]

Protein Classification

DNA-directed RNA polymerase subunit beta'( domain architecture ID 12103661)

DNA-directed RNA polymerase subunit beta' catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 47-231 1.13e-70

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


:

Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 214.72  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358081    47 VDRSGLQPQHKNVLLNKLPYQEPHSWIHLTEKYQRQAFGRYGAQSNVNPKICFDS---HGEKDSRQVMQLETLLKMLEKN 123
Cdd:pfam10147  17 VDKSTLLPQHRNILAGVPPRRQPDSWIQLTEKYARKQFGRYGAKSGVNPKSLFPSaeqLEELEAEEREWYPSLAQMLESN 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358081   124 RAQKAEELARINAREEDIAKKMEKLTQWKADLHAKIAKREADAAAAIQRKERLVEEVRRHFGFKVDTRDERFKEMLEQKE 203
Cdd:pfam10147  97 RAQKAEKEARRQAREQEIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEMLQQKE 176

                         170       180
                  ....*....|....*....|....*...
gi 21358081   204 KEDKKKQKEAKRKAKEEKMMAKLVEKAS 231
Cdd:pfam10147 177 KEDKKKVKEAKRKEKEEKRMAKLVEATS 204
 
Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 47-231 1.13e-70

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 214.72  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358081    47 VDRSGLQPQHKNVLLNKLPYQEPHSWIHLTEKYQRQAFGRYGAQSNVNPKICFDS---HGEKDSRQVMQLETLLKMLEKN 123
Cdd:pfam10147  17 VDKSTLLPQHRNILAGVPPRRQPDSWIQLTEKYARKQFGRYGAKSGVNPKSLFPSaeqLEELEAEEREWYPSLAQMLESN 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358081   124 RAQKAEELARINAREEDIAKKMEKLTQWKADLHAKIAKREADAAAAIQRKERLVEEVRRHFGFKVDTRDERFKEMLEQKE 203
Cdd:pfam10147  97 RAQKAEKEARRQAREQEIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEMLQQKE 176

                         170       180
                  ....*....|....*....|....*...
gi 21358081   204 KEDKKKQKEAKRKAKEEKMMAKLVEKAS 231
Cdd:pfam10147 177 KEDKKKVKEAKRKEKEEKRMAKLVEATS 204
 
Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 47-231 1.13e-70

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 214.72  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358081    47 VDRSGLQPQHKNVLLNKLPYQEPHSWIHLTEKYQRQAFGRYGAQSNVNPKICFDS---HGEKDSRQVMQLETLLKMLEKN 123
Cdd:pfam10147  17 VDKSTLLPQHRNILAGVPPRRQPDSWIQLTEKYARKQFGRYGAKSGVNPKSLFPSaeqLEELEAEEREWYPSLAQMLESN 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358081   124 RAQKAEELARINAREEDIAKKMEKLTQWKADLHAKIAKREADAAAAIQRKERLVEEVRRHFGFKVDTRDERFKEMLEQKE 203
Cdd:pfam10147  97 RAQKAEKEARRQAREQEIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEMLQQKE 176

                         170       180
                  ....*....|....*....|....*...
gi 21358081   204 KEDKKKQKEAKRKAKEEKMMAKLVEKAS 231
Cdd:pfam10147 177 KEDKKKVKEAKRKEKEEKRMAKLVEATS 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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