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caps capricious [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39493, updated on 4-Jan-2025

Summary

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Official Symbol
capsprovided by FlyBase
Official Full Name
capriciousprovided by FlyBase
Primary source
FLYBASE:FBgn0023095
Locus tag
Dmel_CG11282
See related
AllianceGenome:FB:FBgn0023095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD07388; Caps; CAPS; CG11282; CT31495; Dmel\CG11282; l(3)02937; l(3)rM632
Summary
Involved in several processes, including axon guidance; branch fusion, open tracheal system; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in muscle cell projection. Colocalizes with cytoneme. Is expressed in several structures, including antennal lobe glomerulus; embryonic/larval motor neurons; gut section; larval somatic muscle cell; and organism subdivision. Orthologous to human LRRC4C (leucine rich repeat containing 4C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See caps in Genome Data Viewer
Location:
70A3-70A4; 3-40 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13228692..13279642)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13221792..13272742)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43914 Neighboring gene long non-coding RNA:CR45098 Neighboring gene transfer RNA:Aspartic acid-GTC 1-10 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43146 Neighboring gene long non-coding RNA:CR43913

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila synapse formation: regulation by transmembrane protein with Leu-rich repeats, CAPRICIOUS. Shishido E, et al. Science, 1998 Jun 26. PMID 9641918
  2. Axon guidance of Drosophila SNb motoneurons depends on the cooperative action of muscular Krüppel and neuronal capricious activities. Abrell S, et al. Mech Dev, 2001 Nov. PMID 11677048
  3. Functional dissection of drosophila capricious: its novel roles in neuronal pathfinding and selective synapse formation. Taniguchi H, et al. J Neurobiol, 2000 Jan. PMID 10623905
  4. The Selector Gene apterous and Notch Are Required to Locally Increase Mechanical Cell Bond Tension at the Drosophila Dorsoventral Compartment Boundary. Michel M, et al. PLoS One, 2016. PMID 27552097, Free PMC Article
  5. Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan. Milán M, et al. Dev Dyn, 2005 Jul. PMID 15830355

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caps and tartan proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation
    Title: Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map.
  2. In caps mutants, or in double mutants lacking both CAPS and the closely related protein Tartan, we observed fewer contacts between myopodia of M12 and the presynaptic growth cones during the process of initial neuromuscular interaction.
    Title: Target recognition at the tips of postsynaptic filopodia: accumulation and function of Capricious.
  3. Capricious and Tartan contribute to the adhesive properties of the cells in the morphogenetic furrow and that this regulated adhesion participates in the control of spacing ommatidial clusters
    Title: Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan.
  4. extracellular domains of Capricious and Tartan may work as ligands of an unknown dorsal cell surface protein, and required to transduce a signal necessary for the establishment of the DV boundary
    Title: Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in larval salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with cytoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in muscle cell projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
capricious
Names
CG11282-PA
CG11282-PB
CG11282-PD
CG11282-PE
caps-PA
caps-PB
caps-PD
caps-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13228692..13279642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079332.4 → NP_524056.3  capricious, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524056.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96671, Q9VU53
    Related
    FBpp0075570
    Conserved Domains (4) summary
    smart00082
    Location:395 → 445
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:147 → 397
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:97 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143 → 201
    LRR_8; Leucine rich repeat

  2. NM_001043139.4 → NP_001036604.2  capricious, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036604.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8F0
    Conserved Domains (4) summary
    smart00082
    Location:395 → 445
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:147 → 397
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:97 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143 → 201
    LRR_8; Leucine rich repeat

  3. NM_001316462.1 → NP_001303391.1  capricious, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WP14
    Conserved Domains (4) summary
    smart00082
    Location:395 → 445
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:147 → 397
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:97 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143 → 201
    LRR_8; Leucine rich repeat

  4. NM_168540.3 → NP_729880.2  capricious, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729880.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96671, Q9VU53
    Related
    FBpp0075571
    Conserved Domains (4) summary
    smart00082
    Location:395 → 445
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:147 → 397
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:97 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143 → 201
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WP14 A0A0S0WP14
O96671 O96671
Q0E8F0 Q0E8F0
Q8IH19 Q8IH19
Q9VU53 Q9VU53

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