|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
135-398 |
1.37e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 106.17 E-value: 1.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 135 SNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRishidphALDGLDNLRVLYLDDNTLTTVPGELTfqA 214
Cdd:COG4886 64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELA--N 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 215 LHSLAELYLGTNSFMTIPGgAFQDLKGLTRLDLRGAGLHNISgDALKGLVSLRFLDLSDNRLPAIPtAAFQRLGRLEQLN 294
Cdd:COG4886 135 LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 295 IGQNDFEVISSgafsglrelrhleltgaqrlrrvesgAFSGNTNLEHLNLSSNkQLNELSSiaLGGLPHLSTVVLKANQL 374
Cdd:COG4886 212 LSGNQLTDLPE--------------------------PLANLTNLETLDLSNN-QLTDLPE--LGNLTNLEELDLSNNQL 262
|
250 260
....*....|....*....|....
gi 45549202 375 SSLDEgLVPWADLQTLDLSENPFE 398
Cdd:COG4886 263 TDLPP-LANLTNLKTLDLSNNQLT 285
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
124-321 |
4.15e-15 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 74.44 E-value: 4.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 124 LHLDHNKIGQVSNktFLGLSTISVLNLRGNLIAELEyrTFSPMVKLAELNLGQNRISHIDPhaLDGLDNLRVLYLDDNTL 203
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 204 TTVPGeltFQALHSLAELYLGTnsfmtipggafQDLKGLTRLDLRGAGLHNISGdalkglvSLRFLDLSDNRLPAIptAA 283
Cdd:cd21340 81 SVVEG---LENLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAALSN-------SLRVLNISGNNIDSL--EP 137
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 45549202 284 FQRLGRLEQLNIGQNDFEVIS--SGAFSGLRELRHLELTG 321
Cdd:cd21340 138 LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTG 177
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
143-201 |
6.15e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.22 E-value: 6.15e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 45549202 143 STISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDN 201
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
72-397 |
1.25e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 57.94 E-value: 1.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 72 PAIQRLVIKNNKLK-TIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNK--------IGQVSNKTFL-- 140
Cdd:PLN00113 140 PNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlvgqipreLGQMKSLKWIyl 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 141 --------------GLSTISVLNL-RGNLIAELEyRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTT 205
Cdd:PLN00113 220 gynnlsgeipyeigGLTSLNHLDLvYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 206 VPGELTFQaLHSLAELYLGTNSFM-TIPGGafqdLKGLTRLDLRGAGLHNISGDALKGL---VSLRFLDLSDNRLPAIPT 281
Cdd:PLN00113 299 EIPELVIQ-LQNLEILHLFSNNFTgKIPVA----LTSLPRLQVLQLWSNKFSGEIPKNLgkhNNLTVLDLSTNNLTGEIP 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 282 AAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLeltgaqrlrRVESGAFSGNTNLE--------HLNLSSNKQLNEL 353
Cdd:PLN00113 374 EGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRV---------RLQDNSFSGELPSEftklplvyFLDISNNNLQGRI 444
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 45549202 354 SSIALgGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPF 397
Cdd:PLN00113 445 NSRKW-DMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQF 487
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
395-445 |
1.44e-08 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 50.89 E-value: 1.44e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 45549202 395 NPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDlPLAHLAEPLLGC 445
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
369-445 |
1.11e-07 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 55.09 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 369 LKANQLSSLDEGLVP-WADLQTLDLSENPFECDCRLLWLRHLLVSRNAS-GQYAPVICAYPTALRDLPLahLAEPLL--G 444
Cdd:TIGR00864 2 ISNNKISTIEEGICAnLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKvRQPEAALCAGPGALAGQPL--LGIPLLdsG 79
|
.
gi 45549202 445 C 445
Cdd:TIGR00864 80 C 80
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-155 |
4.53e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 4.53e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 96 QLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLI 155
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
135-398 |
1.37e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 106.17 E-value: 1.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 135 SNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRishidphALDGLDNLRVLYLDDNTLTTVPGELTfqA 214
Cdd:COG4886 64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELA--N 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 215 LHSLAELYLGTNSFMTIPGgAFQDLKGLTRLDLRGAGLHNISgDALKGLVSLRFLDLSDNRLPAIPtAAFQRLGRLEQLN 294
Cdd:COG4886 135 LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 295 IGQNDFEVISSgafsglrelrhleltgaqrlrrvesgAFSGNTNLEHLNLSSNkQLNELSSiaLGGLPHLSTVVLKANQL 374
Cdd:COG4886 212 LSGNQLTDLPE--------------------------PLANLTNLETLDLSNN-QLTDLPE--LGNLTNLEELDLSNNQL 262
|
250 260
....*....|....*....|....
gi 45549202 375 SSLDEgLVPWADLQTLDLSENPFE 398
Cdd:COG4886 263 TDLPP-LANLTNLKTLDLSNNQLT 285
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
95-399 |
1.01e-23 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 103.47 E-value: 1.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 95 AQLTFLDLSFNDMLTIPErSFAYHAKLQELHLDHNKIGQVSnKTFLGLSTISVLNLRGNLIAELEyRTFSPMVKLAELNL 174
Cdd:COG4886 113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 175 GQNRISHIdPHALDGLDNLRVLYLDDNTLTTVPGELTfqALHSLAELYLGTNSFMTIPggAFQDLKGLTRLDLRGAGLHN 254
Cdd:COG4886 190 SNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLA--NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 255 ISgdALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGafsglrELRHLELTGAQRLRRVESGAFS 334
Cdd:COG4886 265 LP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL------ILLLLLTTLLLLLLLLKGLLVT 336
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45549202 335 GNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFEC 399
Cdd:COG4886 337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
67-358 |
7.52e-23 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 100.78 E-value: 7.52e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 67 PIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPErSFAYHAKLQELHLDHNKIGQVSnKTFLGLSTIS 146
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLK 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 147 VLNLRGNLIAELEYrTFSPMVKLAELNLGQNRISHIdPHALDGLDNLRVLYLDDNTLTTVPGeltFQALHSLAELYLGTN 226
Cdd:COG4886 186 ELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 227 SFMTIPGGAfqDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPT--AAFQRLGRLEQLNIGQNDFEVIS 304
Cdd:COG4886 261 QLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELliLLLLLTTLLLLLLLLKGLLVTLT 338
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 45549202 305 SGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIAL 358
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
63-356 |
1.59e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 88.07 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 63 LDVLPIALN--PAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPErSFAYHAKLQELHLDHNKIGQVSnKTFL 140
Cdd:COG4886 125 LTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLG 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 141 GLSTISVLNLRGNLIAELEyRTFSPMVKLAELNLGQNRISHIDphALDGLDNLRVLYLDDNTLTTVPGELTfqaLHSLAE 220
Cdd:COG4886 203 NLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLAN---LTNLKT 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 221 LYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISG--DALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQN 298
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELliLLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 45549202 299 DFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSI 356
Cdd:COG4886 357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
190-398 |
1.71e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 87.68 E-value: 1.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 190 LDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGaglhnisGDALKGLVSLRFL 269
Cdd:COG4886 46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 270 DLSDNRLPAIPtAAFQRLGRLEQLNIGQNDFEVISSgAFSGLRELRHLELTGAQrLRRVeSGAFSGNTNLEHLNLSSNkQ 349
Cdd:COG4886 119 DLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDL-PEELGNLTNLKELDLSNN-Q 193
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 45549202 350 LNELSSiALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFE 398
Cdd:COG4886 194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
124-321 |
4.15e-15 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 74.44 E-value: 4.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 124 LHLDHNKIGQVSNktFLGLSTISVLNLRGNLIAELEyrTFSPMVKLAELNLGQNRISHIDPhaLDGLDNLRVLYLDDNTL 203
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 204 TTVPGeltFQALHSLAELYLGTnsfmtipggafQDLKGLTRLDLRGAGLHNISGdalkglvSLRFLDLSDNRLPAIptAA 283
Cdd:cd21340 81 SVVEG---LENLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAALSN-------SLRVLNISGNNIDSL--EP 137
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 45549202 284 FQRLGRLEQLNIGQNDFEVIS--SGAFSGLRELRHLELTG 321
Cdd:cd21340 138 LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTG 177
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
172-397 |
1.08e-11 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 64.42 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 172 LNLGQNRISHIDphALDGLDNLRVLYLDDNTLTTVPGeltFQALHSLAELYLGTNSfmtipggafqdlkgLTRLDlrgaG 251
Cdd:cd21340 7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN---LEFLTNLTHLYLQNNQ--------------IEKIE----N 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 252 LHNisgdalkgLVSLRFLDLSDNRLpaiptaafQRLGRLEQLnigqndfevissgafSGLRELrHLEltgAQRLRRVESG 331
Cdd:cd21340 64 LEN--------LVNLKKLYLGGNRI--------SVVEGLENL---------------TNLEEL-HIE---NQRLPPGEKL 108
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45549202 332 AFSGNT------NLEHLNLSSNKqlneLSSIA-LGGLPHLSTVVLKANQLSSLDEGLVP---WADLQTLDLSENPF 397
Cdd:cd21340 109 TFDPRSlaalsnSLRVLNISGNN----IDSLEpLAPLRNLEQLDASNNQISDLEELLDLlssWPSLRELDLTGNPV 180
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
143-201 |
6.15e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.22 E-value: 6.15e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 45549202 143 STISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDN 201
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
217-276 |
2.75e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.30 E-value: 2.75e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 217 SLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRL 276
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
196-398 |
3.49e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.79 E-value: 3.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 196 LYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNR 275
Cdd:COG4886 4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 276 LPAIPTAAFQRLGRLEQLNIGQNDfevissgAFSGLRELRHLELTGAQrLRRVESgAFSGNTNLEHLNLSSNkQLNELSS 355
Cdd:COG4886 84 LLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-LTDLPE-ELANLTNLKELDLSNN-QLTDLPE 153
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 45549202 356 iALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFE 398
Cdd:COG4886 154 -PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
265-321 |
4.27e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.53 E-value: 4.27e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 45549202 265 SLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTG 321
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
147-397 |
5.49e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 57.75 E-value: 5.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 147 VLNLRGNLIAELEYRTFSPMVK----LAELNLGQN------RISHIDPHALDGLDNLRVLYLDDNTLTtVPGELTFQALH 216
Cdd:cd00116 27 VLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNetgripRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLESLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 217 ---SLAELYLgTNSFMTIPGGAfqdlkgltrldlrgaglhnISGDALKGLV-SLRFLDLSDNRL---PAIPTA-AFQRLG 288
Cdd:cd00116 106 rssSLQELKL-NNNGLGDRGLR-------------------LLAKGLKDLPpALEKLVLGRNRLegaSCEALAkALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 289 RLEQLNIGQNDFEVisSGA---FSGLRELRHLEL----------TGAQRLrrveSGAFSGNTNLEHLNLSSNK----QLN 351
Cdd:cd00116 166 DLKELNLANNGIGD--AGIralAEGLKANCNLEVldlnnngltdEGASAL----AETLASLKSLEVLNLGDNNltdaGAA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 45549202 352 ELSSIALGGLPHLSTVVLKANQLS-----SLDEGLVPWADLQTLDLSENPF 397
Cdd:cd00116 240 ALASALLSPNISLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKF 290
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
168-228 |
8.89e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 8.89e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45549202 168 KLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGElTFQALHSLAELYLGTNSF 228
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
72-397 |
1.25e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 57.94 E-value: 1.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 72 PAIQRLVIKNNKLK-TIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNK--------IGQVSNKTFL-- 140
Cdd:PLN00113 140 PNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlvgqipreLGQMKSLKWIyl 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 141 --------------GLSTISVLNL-RGNLIAELEyRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTT 205
Cdd:PLN00113 220 gynnlsgeipyeigGLTSLNHLDLvYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 206 VPGELTFQaLHSLAELYLGTNSFM-TIPGGafqdLKGLTRLDLRGAGLHNISGDALKGL---VSLRFLDLSDNRLPAIPT 281
Cdd:PLN00113 299 EIPELVIQ-LQNLEILHLFSNNFTgKIPVA----LTSLPRLQVLQLWSNKFSGEIPKNLgkhNNLTVLDLSTNNLTGEIP 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 282 AAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLeltgaqrlrRVESGAFSGNTNLE--------HLNLSSNKQLNEL 353
Cdd:PLN00113 374 EGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRV---------RLQDNSFSGELPSEftklplvyFLDISNNNLQGRI 444
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 45549202 354 SSIALgGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPF 397
Cdd:PLN00113 445 NSRKW-DMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQF 487
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
395-445 |
1.44e-08 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 50.89 E-value: 1.44e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 45549202 395 NPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDlPLAHLAEPLLGC 445
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
192-249 |
2.85e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.22 E-value: 2.85e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 45549202 192 NLRVLYLDDNTLTTVPGElTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRG 249
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
38-280 |
3.74e-08 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 56.24 E-value: 3.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 38 LGLANCPNGCECDDDTLMVNCGEgtLDVLPIALNPAIQRLVIKNNKLKTIDSSMQFYAQLtfLDLSFNDMLTIPERsfaY 117
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNE--LKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQE--MELSINRITELPER---L 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 118 HAKLQELHLDHNKIGQVSNKTFLGLSTISVLnlRGNLIAELEYRTFSpmvkLAELNLGQNRISHIdPHALDglDNLRVLY 197
Cdd:PRK15370 261 PSALQSLDLFHNKISCLPENLPEELRYLSVY--DNSIRTLPAHLPSG----ITHLNVQSNSLTAL-PETLP--PGLKTLE 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 198 LDDNTLTTVPGELTfqalHSLAELYLGTNSFMTIPggafQDL-KGLTRLDLRGAGLHNISGDAlkgLVSLRFLDLSDNRL 276
Cdd:PRK15370 332 AGENALTSLPASLP----PELQVLDVSKNQITVLP----ETLpPTITTLDVSRNALTNLPENL---PAALQIMQASRNNL 400
|
....
gi 45549202 277 PAIP 280
Cdd:PRK15370 401 VRLP 404
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
241-300 |
5.23e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.45 E-value: 5.23e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 241 GLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDF 300
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
100-395 |
6.57e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 55.62 E-value: 6.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 100 LDLSFNDML-TIPERSFAYHAKLQELHLDHNKI-GQVSNKTFLGLSTisvLNLRGNLIAELEYRTFSPMVKLAELNLGQN 177
Cdd:PLN00113 98 INLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLET---LDLSNNMLSGEIPNDIGSFSSLKVLDLGGN 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 178 RISHIDPHALDGLDNLRVLYLDDNTLT-TVPGELTfqALHSLAELYLGTNsfmtipggafqdlkgltrldlrgaglhNIS 256
Cdd:PLN00113 175 VLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELG--QMKSLKWIYLGYN---------------------------NLS 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 257 GD---ALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTgaqrlrrveSGAF 333
Cdd:PLN00113 226 GEipyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLS---------DNSL 296
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45549202 334 SGN--------TNLEHLNLSSNKQLNELsSIALGGLPHLSTVVLKANQLS-SLDEGLVPWADLQTLDLSEN 395
Cdd:PLN00113 297 SGEipelviqlQNLEILHLFSNNFTGKI-PVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTN 366
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
369-445 |
1.11e-07 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 55.09 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 369 LKANQLSSLDEGLVP-WADLQTLDLSENPFECDCRLLWLRHLLVSRNAS-GQYAPVICAYPTALRDLPLahLAEPLL--G 444
Cdd:TIGR00864 2 ISNNKISTIEEGICAnLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKvRQPEAALCAGPGALAGQPL--LGIPLLdsG 79
|
.
gi 45549202 445 C 445
Cdd:TIGR00864 80 C 80
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
312-374 |
3.71e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.13 E-value: 3.71e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45549202 312 RELRHLELTGaQRLRRVESGAFSGNTNLEHLNLSSNKqLNELSSIALGGLPHLSTVVLKANQL 374
Cdd:pfam13855 1 PNLRSLDLSN-NRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-155 |
4.53e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 4.53e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 96 QLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLI 155
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_5 |
pfam13306 |
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
230-347 |
4.32e-05 |
|
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.
Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 43.30 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 230 TIPGGAFQDLKgLTRLDLrGAGLHNISGDALKGLVSLRFLDLSDNrLPAIPTAAFQRLGrLEQLNIGQNdFEVISSGAFS 309
Cdd:pfam13306 2 SIGSYAFYNCS-LTSITI-PSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFS 76
|
90 100 110
....*....|....*....|....*....|....*...
gi 45549202 310 GLRELRHLELTGAqrLRRVESGAFSgNTNLEHLNLSSN 347
Cdd:pfam13306 77 NCSNLKSITLPSN--LTSIGSYAFS-NCSLKSITIPSS 111
|
|
| LRR_5 |
pfam13306 |
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
265-357 |
1.09e-04 |
|
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.
Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 42.15 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 265 SLRFLDLSDNrLPAIPTAAFQRLGRLEQLNIGQNdFEVISSGAFSGLrELRHLELTgaQRLRRVESGAFSGNTNLEHLNL 344
Cdd:pfam13306 12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIP--SSLTSIGEYAFSNCSNLKSITL 86
|
90
....*....|...
gi 45549202 345 SSNkqLNELSSIA 357
Cdd:pfam13306 87 PSN--LTSIGSYA 97
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
72-236 |
1.56e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.84 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 72 PAIQRLVIKNNKLK-TIDSSMQFYAQLTFLDLSFNDMLTIPERSFAyHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNL 150
Cdd:PLN00113 428 PLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFGGLPDSFG-SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 151 RGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLT-TVPGELTfqALHSLAELYLGTNSFM 229
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG--NVESLVQVNISHNHLH 584
|
....*....
gi 45549202 230 -TIPG-GAF 236
Cdd:PLN00113 585 gSLPStGAF 593
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
175-395 |
2.09e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.07 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 175 GQNRISHIDPhALDGLDNLRVLYLDDNTLT-TVPGELtFQALHSLAELYLGTNSFM-TIPGGAfqdLKGLTRLDLRGAGL 252
Cdd:PLN00113 78 GKNISGKISS-AIFRLPYIQTINLSNNQLSgPIPDDI-FTTSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNML 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 253 HNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFeviSSGAFSGLRELRHLELT--GAQRLRRVES 330
Cdd:PLN00113 153 SGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQMKSLKWIylGYNNLSGEIP 229
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45549202 331 GAFSGNTNLEHLNLSSNKQLNELSSiALGGLPHLSTVVLKANQLS-SLDEGLVPWADLQTLDLSEN 395
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDN 294
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
91-396 |
2.22e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 43.63 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 91 MQFYAQLTFLDLSF---NDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTIS---VLNLRGNLIAELEYRTFS 164
Cdd:COG5238 83 EAFPTQLLVVDWEGaeeVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRInliQVLKDPLGGNAVHLLGLA 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 165 PMVKLAELnlgqnrisHIDPHALDGlDNLRVLYLDDNTLTTVPGELTFQALH---SLAELYLGTNSFmtipggafqDLKG 241
Cdd:COG5238 163 ARLGLLAA--------ISMAKALQN-NSVETVYLGCNQIGDEGIEELAEALTqntTVTTLWLKRNPI---------GDEG 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 242 LTRLdlrgaglhnisGDALKGLVSLRFLDLSDNRLPAIPTAAF----QRLGRLEQLNIGQNdfevissgafsglrelrHL 317
Cdd:COG5238 225 AEIL-----------AEALKGNKSLTTLDLSNNQIGDEGVIALaealKNNTTVETLYLSGN-----------------QI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 318 ELTGAQRLrrveSGAFSGNTNLEHLNLSSNkQLNELSSIALG-GLPHLSTVV---LKANQLS-----SLDEGLVPWADLQ 388
Cdd:COG5238 277 GAEGAIAL----AKALQGNTTLTSLDLSVN-RIGDEGAIALAeGLQGNKTLHtlnLAYNGIGaqgaiALAKALQENTTLH 351
|
....*...
gi 45549202 389 TLDLSENP 396
Cdd:COG5238 352 SLDLSDNQ 359
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
71-299 |
1.08e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 41.70 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 71 NPAIQRLVIKNNK-----LKTIDSSMQFYAQLTFLDLSFNDM----LTIPERSFAYHAKLQELHLDHNKIGqvsNKTFLG 141
Cdd:COG5238 207 NTTVTTLWLKRNPigdegAEILAEALKGNKSLTTLDLSNNQIgdegVIALAEALKNNTTVETLYLSGNQIG---AEGAIA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 142 LSTisvlNLRGNliaeleyrtfspmVKLAELNLGQNRIShiDPHAL---DGLDN---LRVLYLDDNTLTTVPGELTFQAL 215
Cdd:COG5238 284 LAK----ALQGN-------------TTLTSLDLSVNRIG--DEGAIalaEGLQGnktLHTLNLAYNGIGAQGAIALAKAL 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 216 hslaelylgtnsfmtipggafQDLKGLTRLDLRGAGLHNISGDAL----KGLVSLRFLDLSDNRLP---AIPTAAFQRLG 288
Cdd:COG5238 345 ---------------------QENTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIGkqgAEALIDALQTN 403
|
250
....*....|.
gi 45549202 289 RLEQLNIGQND 299
Cdd:COG5238 404 RLHTLILDGNL 414
|
|
| LRR_5 |
pfam13306 |
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
230-340 |
3.19e-03 |
|
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.
Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 37.91 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549202 230 TIPGGAFQDLKGLTRLDLrGAGLHNISGDALKGLvSLRFLDLSDNrLPAIPTAAFQRLGRLEQLNIGQNdFEVISSGAFS 309
Cdd:pfam13306 24 SIGEYAFSNCTSLKSITL-PSSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFS 99
|
90 100 110
....*....|....*....|....*....|.
gi 45549202 310 GLReLRHLELTGAqrLRRVESGAFSGNTNLE 340
Cdd:pfam13306 100 NCS-LKSITIPSS--VTTIGSYAFSNCSNLK 127
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
337-397 |
3.59e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.96 E-value: 3.59e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45549202 337 TNLEHLNLSSNKqLNELSSIALGGLPHLSTVVLKANQLSSLDEG-LVPWADLQTLDLSENPF 397
Cdd:pfam13855 1 PNLRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
|
|
| |
