Pex7 Peroxin 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pex7provided by FlyBase
Official Full Name: Peroxin 7provided by FlyBase
Primary source: FLYBASE:FBgn0035922
Locus tag: Dmel_CG6486
See related: AllianceGenome:FB:FBgn0035922
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6486; DmelPex7; Dmel\CG6486; PEX&; PEX7
Summary: Predicted to enable peroxisome matrix targeting signal-2 binding activity. Involved in protein import into peroxisome matrix. Located in cytosol and peroxisome. Is expressed in embryonic cortex; organism; supraesophageal ganglion; ventral nerve cord; and yolk. Used to study Peroxisome biogenesis disorder 9B. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 9B and rhizomelic chondrodysplasia punctata type 1. Orthologous to human PEX7 (peroxisomal biogenesis factor 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8647145..8651011)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8640245..8644111)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The role of Peroxin 7 during Drosophila embryonic development.
Title: The role of Peroxin 7 during Drosophila embryonic development.
Pex7 fly mutants are affected in lipid processing and exhibit minor defects in brain development.
Title: Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables peroxisome matrix targeting signal-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome matrix targeting signal-2 binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein import into peroxisome matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain