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Conserved domains on  [gi|221330994|ref|NP_001137914|]
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peroxin 7, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-328 4.13e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  53 SSSTDGQ------SLGELCRLEW--SDGLFDVAWCPYAADIAaTASGDGSLQIWcgldgesasnQLTPKQPLICLQEHKN 124
Cdd:cd00200   26 TGSGDGTikvwdlETGELLRTLKghTGPVRDVAASADGTYLA-SGSSDKTIRLW----------DLETGECVRTLTGHTS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 125 EVYSLDWgeKWNYHTLLSGSWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPliANLF-ASVSTDGHLNLWNSLdfAGK 203
Cdd:cd00200   95 YVSSVAF--SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLR--TGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 204 PLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWDLRKmrTHVFELYSG-EFAVRRLACSPHSAaVLASANYDFTTR 282
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST--GKCLGTLRGhENGVNSVAFSPDGY-LLASGSEDGTIR 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 221330994 283 IWNLERGESAQEVNArHTEFVCGLDWNPHrTHQLADCGWDSLANVY 328
Cdd:cd00200  245 VWDLRTGECVQTLSG-HTNSVTSLAWSPD-GKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-328 4.13e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  53 SSSTDGQ------SLGELCRLEW--SDGLFDVAWCPYAADIAaTASGDGSLQIWcgldgesasnQLTPKQPLICLQEHKN 124
Cdd:cd00200   26 TGSGDGTikvwdlETGELLRTLKghTGPVRDVAASADGTYLA-SGSSDKTIRLW----------DLETGECVRTLTGHTS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 125 EVYSLDWgeKWNYHTLLSGSWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPliANLF-ASVSTDGHLNLWNSLdfAGK 203
Cdd:cd00200   95 YVSSVAF--SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLR--TGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 204 PLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWDLRKmrTHVFELYSG-EFAVRRLACSPHSAaVLASANYDFTTR 282
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST--GKCLGTLRGhENGVNSVAFSPDGY-LLASGSEDGTIR 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 221330994 283 IWNLERGESAQEVNArHTEFVCGLDWNPHrTHQLADCGWDSLANVY 328
Cdd:cd00200  245 VWDLRTGECVQTLSG-HTNSVTSLAWSPD-GKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
70-322 5.33e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 5.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  70 SDGLFDVAWCPyaaD--IAATASGDGSLQIWCGLDGesasnqltpkQPLICLQEHKNEVYSLDW---GekwnyHTLLSGS 144
Cdd:COG2319  162 SGAVTSVAFSP---DgkLLASGSDDGTVRLWDLATG----------KLLRTLTGHTGAVRSVAFspdG-----KLLASGS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 145 WDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPLiANLFASVSTDGHLNLWNSLDfaGKPLMSIEAHASEALCCDWSHfD 224
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP-D 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 225 RNVLVTGGSDGLIRGWDLRKmRTHVFELYSGEFAVRRLACSPHSaAVLASANYDFTTRIWNLERGESAQEVNArHTEFVC 304
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVT 376

                        250
                 ....*....|....*...
gi 221330994 305 GLDWNPHrTHQLADCGWD 322
Cdd:COG2319  377 SVAFSPD-GRTLASGSAD 393
PTZ00421 PTZ00421
coronin; Provisional
 223-309 7.43e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 223 FDRNVLVTGGSDGLIRGWDL------RKMRTHVFELYSGEFAVRRLACSPHSAAVLASANYDFTTRIWNLERGeSAQEVN 296
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERG-KAVEVI 164

                         90
                 ....*....|...
gi 221330994 297 ARHTEFVCGLDWN 309
Cdd:PTZ00421 165 KCHSDQITSLEWN 177
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-241 7.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 221330994   202 GKPLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWD 241
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
113-153 2.03e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 221330994  113 KQPLICLQEHKNEVYSLDWGEkwNYHTLLSGSWDCTLKLWD 153
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-328 4.13e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  53 SSSTDGQ------SLGELCRLEW--SDGLFDVAWCPYAADIAaTASGDGSLQIWcgldgesasnQLTPKQPLICLQEHKN 124
Cdd:cd00200   26 TGSGDGTikvwdlETGELLRTLKghTGPVRDVAASADGTYLA-SGSSDKTIRLW----------DLETGECVRTLTGHTS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 125 EVYSLDWgeKWNYHTLLSGSWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPliANLF-ASVSTDGHLNLWNSLdfAGK 203
Cdd:cd00200   95 YVSSVAF--SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLR--TGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 204 PLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWDLRKmrTHVFELYSG-EFAVRRLACSPHSAaVLASANYDFTTR 282
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST--GKCLGTLRGhENGVNSVAFSPDGY-LLASGSEDGTIR 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 221330994 283 IWNLERGESAQEVNArHTEFVCGLDWNPHrTHQLADCGWDSLANVY 328
Cdd:cd00200  245 VWDLRTGECVQTLSG-HTNSVTSLAWSPD-GKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
70-322 5.33e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 5.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  70 SDGLFDVAWCPyaaD--IAATASGDGSLQIWCGLDGesasnqltpkQPLICLQEHKNEVYSLDW---GekwnyHTLLSGS 144
Cdd:COG2319  162 SGAVTSVAFSP---DgkLLASGSDDGTVRLWDLATG----------KLLRTLTGHTGAVRSVAFspdG-----KLLASGS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 145 WDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPLiANLFASVSTDGHLNLWNSLDfaGKPLMSIEAHASEALCCDWSHfD 224
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP-D 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 225 RNVLVTGGSDGLIRGWDLRKmRTHVFELYSGEFAVRRLACSPHSaAVLASANYDFTTRIWNLERGESAQEVNArHTEFVC 304
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVT 376

                        250
                 ....*....|....*...
gi 221330994 305 GLDWNPHrTHQLADCGWD 322
Cdd:COG2319  377 SVAFSPD-GRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 70-312 2.29e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 2.29e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  70 SDGLFDVAWCPyAADIAATASGDGSLQIWcgldgesasnQLTPKQPLICLQEHKNEVYSLDWgekWNYHT-LLSGSWDCT 148
Cdd:cd00200    9 TGGVTCVAFSP-DGKLLATGSGDGTIKVW----------DLETGELLRTLKGHTGPVRDVAA---SADGTyLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 149 LKLWDCNRQNSITTFVGHNDLIYGAKFSPLIaNLFASVSTDGHLNLWNSLDfaGKPLMSIEAHASEALCCDWSHFDRnVL 228
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSPDGT-FV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 229 VTGGSDGLIRGWDLRKMRT-HVFELYSGEfaVRRLACSPHSAAVLASANyDFTTRIWNLERGESAQEVNArHTEFVCGLD 307
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCvATLTGHTGE--VNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRG-HENGVNSVA 226


                 ....*
gi 221330994 308 WNPHR 312
Cdd:cd00200  227 FSPDG 231
WD40 COG2319
WD40 repeat [General function prediction only];
14-287 7.92e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 7.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  14 YSLRFSPfEANYLLLATS----QLYGLAGGGSLFLLEQNSNTNSS---STDGQSL----------------GELCR--LE 68
Cdd:COG2319  124 RSVAFSP-DGKTLASGSAdgtvRLWDLATGKLLRTLTGHSGAVTSvafSPDGKLLasgsddgtvrlwdlatGKLLRtlTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  69 WSDGLFDVAWCPyaaD--IAATASGDGSLQIWcgldgesasnQLTPKQPLICLQEHKNEVYSLDW---GEkwnyhTLLSG 143
Cdd:COG2319  203 HTGAVRSVAFSP---DgkLLASGSADGTVRLW----------DLATGKLLRTLTGHSGSVRSVAFspdGR-----LLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 144 SWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPlIANLFASVSTDGHLNLWNSLDfaGKPLMSIEAHASEALCCDWSHf 223
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSP- 340

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330994 224 DRNVLVTGGSDGLIRGWDLRKMR-THVFELYSGefAVRRLACSPHSAaVLASANYDFTTRIWNLE 287
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGElLRTLTGHTG--AVTSVAFSPDGR-TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-285 4.42e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 4.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  84 DIAATASGDGSLQIWcgldgesasnQLTPKQPLICLQEHKNEVYSLDWGekWNYHTLLSGSWDCTLKLWDCNRQNSITTF 163
Cdd:cd00200  106 RILSSSSRDKTIKVW----------DVETGKCLTTLRGHTDWVNSVAFS--PDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 164 VGHNDLIYGAKFSPlIANLFASVSTDGHLNLWNSLdfAGKPLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWDLR 243
Cdd:cd00200  174 TGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 221330994 244 KmRTHVFELYSGEFAVRRLACSPhSAAVLASANYDFTTRIWN 285
Cdd:cd00200  250 T-GECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
82-322 4.09e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 4.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  82 AADIAATASGDGSLQIWCGLDGESASNQLTPKQPLICLQEHKNEVYSLDWgeKWNYHTLLSGSWDCTLKLWDCNRQNSIT 161
Cdd:COG2319   37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF--SPDGRLLASASADGTVRLWDLATGLLLR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 162 TFVGHNDLIYGAKFSPLiANLFASVSTDGHLNLWNSLDfaGKPLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWD 241
Cdd:COG2319  115 TLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLAT--GKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 242 LRKmRTHVFELYSGEFAVRRLACSPHSaAVLASANYDFTTRIWNLERGESAQEVNArHTEFVCGLDWNPHRTHqLADCGW 321
Cdd:COG2319  191 LAT-GKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRL-LASGSA 266


                 .
gi 221330994 322 D 322
Cdd:COG2319  267 D 267
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-331 4.05e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 4.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 119 LQEHKNEVYSLDWGEKWNYhtLLSGSWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPlIANLFASVSTDGHLNLWNSl 198
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKL--LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 199 dFAGKPLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWDLRKmRTHVFELYSGEFAVRRLACSPHSaAVLASANYD 278
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221330994 279 FTTRIWNLeRGESAQEVNARHTEFVCGLDWNPhRTHQLADCGWDSLANVYTPQ 331
Cdd:cd00200  157 GTIKLWDL-RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-328 9.78e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 9.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 159 SITTFVGHNDLIYGAKFSPlIANLFASVSTDGHLNLWNSLDfaGKPLMSIEAHASEALCCDWSHFDrNVLVTGGSDGLIR 238
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 239 GWDLRKMRThVFELYSGEFAVRRLACSPHSaAVLASANYDFTTRIWNLERGESAQEVNArHTEFVCGLDWNPHRTHqLAD 318
Cdd:cd00200   77 LWDLETGEC-VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTF-VAS 152

                        170
                 ....*....|
gi 221330994 319 CGWDSLANVY 328
Cdd:cd00200  153 SSQDGTIKLW 162
PTZ00421 PTZ00421
coronin; Provisional
 223-309 7.43e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 223 FDRNVLVTGGSDGLIRGWDL------RKMRTHVFELYSGEFAVRRLACSPHSAAVLASANYDFTTRIWNLERGeSAQEVN 296
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERG-KAVEVI 164

                         90
                 ....*....|...
gi 221330994 297 ARHTEFVCGLDWN 309
Cdd:PTZ00421 165 KCHSDQITSLEWN 177
PTZ00421 PTZ00421
coronin; Provisional
 73-245 6.57e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 6.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  73 LFDVAWCPYAADIAATASGDGSLQIWcGLDGESASNQLTpkQPLICLQEHKNEVYSLdwgekwNYH-----TLLSGSWDC 147
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGW-GIPEEGLTQNIS--DPIVHLQGHTKKVGIV------SFHpsamnVLASAGADM 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 148 TLKLWDCNRQNSITTFVGHNDLIYGAKFSpLIANLFASVSTDGHLNLWNSLDfaGKPLMSIEAHAS-EALCCDWSHFDRN 226
Cdd:PTZ00421 149 VVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRD--GTIVSSVEAHASaKSQRCLWAKRKDL 225

                        170       180
                 ....*....|....*....|..
gi 221330994 227 VLVTGGSDGLIRG---WDLRKM 245
Cdd:PTZ00421 226 IITLGCSKSQQRQimlWDTRKM 247
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 73-242 1.55e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  73 LFDVAWCPYAADIAATASGDGSLQIWcgldgESASNQLTPKqplicLQEHKNEVYSLDWGEKwNYHTLLSGSWDCTLKLW 152
Cdd:PLN00181 535 LSGICWNSYIKSQVASSNFEGVVQVW-----DVARSQLVTE-----MKEHEKRVWSIDYSSA-DPTLLASGSDDGSVKLW 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 153 DCNRQNSITTFVGHNDlIYGAKFSPLIANLFASVSTDgHLNLWNSLDFAGKPLMSIEAHASEAlccDWSHF-DRNVLVTG 231
Cdd:PLN00181 604 SINQGVSIGTIKTKAN-ICCVQFPSESGRSLAFGSAD-HKVYYYDLRNPKLPLCTMIGHSKTV---SYVRFvDSSTLVSS 678

                        170
                 ....*....|.
gi 221330994 232 GSDGLIRGWDL 242
Cdd:PLN00181 679 STDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 73-153 6.31e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 6.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994  73 LFDVAWCPYAADIAATASGDGSLQIWCGLDGESASNQLtpKQPLICLQEHKNEVYSLDWgEKWNYHTLLSGSWDCTLKLW 152
Cdd:PTZ00420  77 ILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEI--KDPQCILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVNIW 153


                 .
gi 221330994 153 D 153
Cdd:PTZ00420 154 D 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-241 7.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 221330994   202 GKPLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWD 241
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-153 1.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 221330994   112 PKQPLICLQEHKNEVYSLDWGEKWNYhtLLSGSWDCTLKLWD 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY--LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
113-153 2.03e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 221330994  113 KQPLICLQEHKNEVYSLDWGEkwNYHTLLSGSWDCTLKLWD 153
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 231-328 4.14e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 231 GGSDGLIRGWDlrKMRTH-VFELYSGEFAVRRLACSPHSAAVLASANYDFTTRIWNL-ERGESAQEVN------ARHTEF 302
Cdd:PTZ00420  50 GGLIGAIRLEN--QMRKPpVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKdpqcilKGHKKK 127

                         90       100
                 ....*....|....*....|....*.
gi 221330994 303 VCGLDWNPHRTHQLADCGWDSLANVY 328
Cdd:PTZ00420 128 ISIIDWNPMNYYIMCSSGFDSFVNIW 153
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-300 6.67e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 6.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 135 WNYH---TLLSGSWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPLIANLFASVSTDGHLNLWNSLDfaGKPLMSIEAH 211
Cdd:PLN00181 540 WNSYiksQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ--GVSIGTIKTK 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330994 212 ASeaLCC-DWSHFDRNVLVTGGSDGLIRGWDLRKMRTHVFELYSGEFAVRRLACSphSAAVLASANYDFTTRIWNLERGE 290
Cdd:PLN00181 618 AN--ICCvQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDLSMSI 693

                        170
                 ....*....|
gi 221330994 291 SAQEVNARHT 300
Cdd:PLN00181 694 SGINETPLHS 703
WD40 pfam00400
WD domain, G-beta repeat;
202-241 1.77e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 221330994  202 GKPLMSIEAHASEALCCDWSHfDRNVLVTGGSDGLIRGWD 241
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 158-196 3.02e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 221330994   158 NSITTFVGHNDLIYGAKFSPLiANLFASVSTDGHLNLWN 196
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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